Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model

European Journal of Anaesthesiology

Volumn 24, Issue 8, 2007, Pages 702-708

  Haller, I ^a   Lirk, P ^a,c   Keller, C ^a   Wang, G K ^b   Gerner, P ^b   Klimaschewski, L ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

Anaesthesia conduction; Antidepressive agents tricyclic; Drug toxicity; Ganglia spinal; Neurons

Indexed keywords

AMITRIPTYLINE; DESIPRAMINE; DOXEPIN; IMIPRAMINE; N METHYLAMITRIPTYLINE; N METHYLDOXEPIN; N PROPYLDOXEPIN; SODIUM CHANNEL; TRICYCLIC ANTIDEPRESSANT AGENT; TRIMIPRAMINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; INCUBATION TIME; NERVE CELL CULTURE; NEUROTOXICITY; ORDO; REGIONAL ANESTHESIA; SENSORY NERVE CELL; SPINAL GANGLION;

AMITRIPTYLINE; ANESTHESIA, CONDUCTION; ANESTHETICS, LOCAL; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; APOPTOSIS; CELL COUNT; CELL CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXEPIN; ELECTRIC IMPEDANCE; FEMALE; GANGLIA, SPINAL; IMIPRAMINE; PAIN; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TIME FACTORS;

EID: 34447534229     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1017/S0265021507000154     Document Type: Article

References (23)

1. Pancrazio J, Kamatchi G, Roscoe A et al. Inhibition of neuronal Na channels by antidepressant drugs. J Pharmacol Exp Ther 1998; 284: 208-214.
2. Strumper D, Durieux ME. Antidepressants as long-acting local anesthetics. Reg Anesth Pain Med 2004; 29: 277-285.
3. Gerner P, Haderer AE, Mujtaba M et al. Assessment of differential blockade by amitriptyline and its N-methyl derivative in different species by different routes. Anesthesiology 2003; 98: 1484-1490.
4. LaBuda CJ, Little PJ. Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat. J Neurosci Methods 2005; 144: 175-181.
5. Fridrich P, Eappen S, Jaeger W et al. Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans: side effects and efficacy. Anesthesiology 2004; 100: 1511-1518.
6. Gerner P, Kao G, Srinivasa V et al. Topical amitriptyline in healthy volunteers. Reg Anesth Pain Med 2003; 28: 289-293.
7. Estebe JP, Myers RR. Amitriptyline neurotoxicity: dose-related pathology after topical application to rat sciatic nerve. Anesthesiology 2004; 100: 1519-1525.
8. Drasner K, Rigler ML, Sessler DI et al. Cauda equina syndrome following intended epidural anesthesia. Anesthesiology 1992; 77: 582-585.
9. Drasner K, Sakura S, Chan VW et al. Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat. Anesthesiology 1994; 80: 847-852.
10. Drasner K. Local anesthetic neurotoxicity: clinical injury and strategies that may minimize risk. Reg Anesth Pain Med 2002; 27: 576-580.
11. Lambert LA, Lambert DH, Strichartz GR. Irreversible conduction block in isolated nerve by high concentrations of local anesthetics. Anesthesiology 1994; 80: 1082-1093.
12. Gerner P. Tricyclic antidepressants and their local anesthetic properties: from bench to bedside and back again. Reg Anesth Pain Med 2004; 29: 286-289.
13. Sudoh Y, Cahoon EE, Gerner P et al. Tricyclic antidepressants as long-acting local anesthetics. Pain 2003; 103: 49-55.
14. Lirk P, Haller I, Myers RR et al. Mitigation of direct neurotoxic effects of lidocaine and amitriptyline by inhibition of p38 mitogen-activated protein kinase in vitro and in vivo. Anesthesiology 2006; 104: 1266-1273.
15. Lirk P, Haller I, Hausott B et al. The neurotoxic effects of amitriptyline in vitro are dose-dependent, and mediated by apoptosis. Anesth Analg 2006; 102: 1728-1733.
16. Popitz-Bergez FA, Leeson S, Strichartz GR et al. Relation between functional deficit and intraneural local anesthetic during peripheral nerve block. A study in the rat sciatic nerve. Anesthesiology 1995; 83: 583-592.
17. Gerner P, Mujtaba M, Khan M et al. N-phenylethyl amitriptyline in rat sciatic nerve blockade. Anesthesiology 2002; 96: 1435-1442.
18. Pollock JE, Neal JM, Stephenson CA et al. Prospective study of the incidence of transient radicular irritation in patients undergoing spinal anesthesia. Anesthesiology 1996; 84: 1361-1367.
19. Pollock JE, Liu SS, Neal JM et al. Dilution of spinal lidocaine does not alter the incidence of transient neurologic symptoms. Anesthesiology 1999; 90: 445-450.
20. Auroy Y, Benhamou D, Bargues L et al. Major complications of regional anesthesia in France: The SOS Regional Anesthesia Hotline Service. Anesthesiology 2002; 97: 1274-1280.
21. Auroy Y, Narchi P, Messiah A et al. Serious complications related to regional anesthesia: results of a prospective survey in France. Anesthesiology 1997; 87: 479-486.
22. Gold MS, Reichling DB, Hampl KF et al. Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther 1998; 285: 413-421.
23. Johnson ME, Uhl CB, Spittler KH et al. Mitochondrial injury and caspase activation by the local anesthetic lidocaine. Anesthesiology 2004; 101: 1184-1194.