High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 292, Issue 6, 2007, Pages

  Herrera, Emilio A ^a   Pulgar, Víctor M ^a   Riquelme, Raquel A ^a   Sanhueza, Emilia M ^a   Reyes, Roberto V ^a   Ebensperger, Germán ^a   Parer, Julian T ^b   Valdéz, Enrique A ^c   Giussani, Dino A ^d   Blanco, Carlos E ^e   Hanson, Mark A ^f   Llanos, Aníbal J ^a,g,h  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Pontificia Universidad Catolica Madre y Maestra   (Dominican Republic)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^g UNIVERSIDAD DE TARAPACÁ   (Chile)

^h UNIVERSITY OF CHILE   (Chile)

Author keywords

Highlands; Hypoxemia; Neonatal lamb; Pulmonary hypertension; Vascular reactivity

Indexed keywords

NITRIC OXIDE; NORADRENALIN; PHENYLEPHRINE;

ALTITUDE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR RESPONSE; CATHETER; CONTROLLED STUDY; DISEASE SEVERITY; FEMORAL ARTERY; GENERAL ANESTHESIA; HEART OUTPUT; HYPOXIA; LUNG ARTERY PRESSURE; MUSCLE CONTRACTILITY; MYOGRAPHY; NEWBORN; NONHUMAN; PREGNANCY; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PULMONARY ARTERY; SENSITIVITY ANALYSIS; VASCULAR RESISTANCE;

ADAPTATION, PHYSIOLOGICAL; ALTITUDE; ALTITUDE SICKNESS; ANIMALS; ANIMALS, NEWBORN; CARDIAC OUTPUT; CHRONIC DISEASE; FEMALE; FETAL HYPOXIA; OXYGEN CONSUMPTION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PULMONARY GAS EXCHANGE; SHEEP;

EID: 34447530854     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00909.2006     Document Type: Article

References (39)

1. Abman SH. Abnormal vasoreactivity in the pathophysiology of persistent pulmonary hypertension of the newborn. Pediatr Rev 20: e103-e109, 1999.
2. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
3. Doyle MP, Walker BR. Attenuation of systemic vasoreactivity in chronically hypoxic rats. Am J Physiol Regul Integr Comp Physiol 260: R1114-R1122, 1991.
4. Emery CJ, Bee D, Barer GR. Mechanical properties and reactivity of vessels in isolated perfused lungs of chronically hypoxic rats. Clin Sci (Lond) 61: 569-580, 1981.
5. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, McMurtry IF. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 287: L656-L664, 2004.
6. Fike CD, Kaplowitz MR, Thomas CJ, Nelin LD. Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs. Am J Physiol Lung Cell Mol Physiol 274: L517-L526, 1998.
7. Gamboa R, Marticorena E. Presión arterial pulmonar en el recién nacido en las grandes alturas. Arch Inst Biol Andina 4: 55-66, 1971.
8. Gao Y, Portugal AD, Negash S, Zhou W, Longo LD, Raj JU. Role of Rho kinases in PKG-mediated relaxation of pulmonary arteries of fetal lambs exposed to chronic high altitude hypoxia. Am J Physiol Lung Cell Mol Physiol 292: L678-L684, 2007.
9. Giussani DA, Spencer JA, Moore PJ, Bennet L, Hanson MA. Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol 461: 431-449, 1993.
10. Giussani DA, Riquelme RA, Sanhueza EM, Hanson MA, Blanco CE, Llanos AJ. Adrenergic and vasopressinergic contributions to the cardiovascular response to acute hypoxaemia in the llama fetus. J Physiol 515: 233-241, 1999.
11. Giussani DA, Phillips PS, Anstee S, Barker DJP. Effects of altitude versus economic status on birth weight and body shape at birth. Pediatr Res 49: 490-494, 2001.
12. Glantz SA, Slinker BK. Primer of Applied Regression and Analysis of Variance, (2nd ed.). New York: McGraw-Hill, p. 418-507, 2001.
13. Hall SM, Hislop AA, Wu Z, Haworth SG. Remodelling of the pulmonary arteries during recovery from pulmonary hypertension induced by neonatal hypoxia. J Pathol 203: 575-583, 2004.
14. Jeffery TK, Morrell NW. Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog Cardiovasc Dis 45: 173-202, 2002.
15. Keyes LE, Armaza JF, Niermeyer S, Vargas E, Young DA, Moore LG. Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia. Pediatr Res 54: 20-25, 2003.
16. Llanos AJ, Riquelme RA, Sanhueza EM, Hanson MA, Blanco CE, Parer JT, Herrera EA, Pulgar VM, Reyes RV, Cabello G, Giussani DA. The fetal llama versus the fetal sheep: different strategies to withstand hypoxia. High Alt Med Biol 4: 193-202, 2003.
17. McMurtry IF, Petrun MD, Reeves JT. Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia. Am J Physiol Heart Circ Physiol 235: H104-H109, 1978.
18. McMurtry IF, Morris KG, Petrun MD. Blunted hypoxic vasoconstriction in lungs from short-term high-altitude rats. Am J Physiol Heart Circ Physiol 238: H849-H857, 1980.
19. Monge C, Leon-Velarde F. Physiological adaptation to high altitude: oxygen transport in mammals and birds. Physiol Rev 71: 1135-1172, 1991.
20. Moore LG, Shriver M, Bemis L, Hickler B, Wilson M, Brutsaert T, Parra E, Vargas E. Maternal adaptation to high-altitude pregnancy: an experiment of nature-a review. Placenta 25, Suppl A: S60-S71, 2004.
21. Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171: 494-499, 2005.
22. Niermeyer S, Yang P, Shanmina D, Zhuang J, Moore LG. Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet. N Engl J Med 333: 1248-1252, 1995.
23. Pearce WJ, Hull AD, Long DM, Longo LD. Developmental changes in ovine cerebral artery composition and reactivity. Am J Physiol Regul Integr Comp Physiol 261: R458-R465, 1991.
24. Portman MA, Standaert TA, Ning XH. Relation of myocardial oxygen consumption and function to high energy phosphate utilization during graded hypoxia and reoxygenation in sheep in vivo. J Clin Invest 95: 2134-2142, 1995.
25. Reeve HL, Michelakis E, Nelson DP, Weir EK, Archer SL. Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol 90: 2249-2256, 2001.
26. Rhodes J. Comparative physiology of hypoxic pulmonary hypertension: historical clues from brisket disease. J Appl Physiol 98: 1092-1100, 2005.
27. Ruijtenbeek K, le Noble FA, Janssen GM, Kessels CG, Fazzi GE, Blanco CE, De Mey JG. Chronic hypoxia stimulates periarterial sympathetic nerve development in chicken embryo. Circulation 102: 2892-2897, 2000.
28. Ruijtenbeek K, Kessels CG, Villamor E, Blanco CE, De Mey JG. Direct effects of acute hypoxia on the reactivity of peripheral arteries of the chicken embryo. Am J Physiol Regul Integr Comp Physiol 283: R331-R338, 2002.
29. Schindler MB, Hislop AA, Haworth SG. Postnatal changes in response to norepinephrine in the normal and pulmonary hypertensive lung. Am J Respir Crit Care Med 170: 641-646, 2004.
30. Schindler MB, Hislop AA, Haworth SG. Porcine pulmonary artery and bronchial responses to endothelin-1 and norepinephrine on recovery from hypoxic pulmonary hypertension. Pediatr Res 60: 71-76, 2006.
31. Shimoda LA, Sham JSK, Sylvester JT. Altered pulmonary vasoreactivity in the chronically hypoxic lung. Physiol Res 49: 549-560, 2000.
32. Stenmark KR, Mecham RP. Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol 59: 89-144, 1997.
33. Stenmark KR, Fagan KA, Frid MG. Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 99: 675-691, 2006.
34. Sui GJ, Liu YH, Cheng XS, Anand IS, Harris E, Harris P, Heath D. Subacute infantile mountain sickness. J Pathol 155: 161-70, 1988.
35. Tucker A, Mc Murtry IF, Reeves JT, Alexander AF, Will DH, Grover RF. Lung vascular smooth muscle as a determinant of pulmonary hypertension at altitude. Am J Physiol 228: 762-767, 1975.
36. Villamor E, Ruijtenbeek K, Pulgar V, De Mey JG, Blanco CE. Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life. Am J Physiol Regul Integr Comp Physiol 282: R917-R927, 2002.
37. Ward JPT, Snetkov VA. Determination of signaling pathways responsible for hypoxic pulmonary vasoconstriction: use of the small vessel myograph. Methods Enzymol 381: 71-87, 2004.
38. Williams SJ, Campbell ME, McMillen C, Davidge ST. Differential effects of maternal hypoxia or nutrient restriction on carotid and femoral vascular function in neonatal rats. Am J Physiol Regul Integr Comp Physiol 288: R360-R367, 2005.
39. Zhao L, Crawley DE, Hughes JM, Evans TW, Winter RJ. Endothelium-derived relaxing factor activity in rat lung during hypoxic pulmonary vascular remodeling. J Appl Physiol 74: 1061-1065, 1993.