Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib

Journal of Biological Chemistry

Volumn 282, Issue 22, 2007, Pages 16379-16390

  Blobaum, Anna L ^a   Marnett, Lawrence J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; BIOASSAY; MOLECULAR STRUCTURE; SUBSTITUTION REACTIONS;

LUMIRACOXIB; MOLECULAR DETERMINANTS;

ENZYME INHIBITION;

CYCLOOXYGENASE 2; LUMIRACOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; DRUG DERIVATIVE; MEMBRANE PROTEIN; PTGS1 PROTEIN, MOUSE; PTGS2 PROTEIN, HUMAN; PTGS2 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; PRIORITY JOURNAL; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HUMAN; KINETICS; MALE; METABOLISM; MISSENSE MUTATION; MOUSE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SHEEP; TIME;

OVIS;

AMINO ACID SUBSTITUTION; ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DICLOFENAC; HUMANS; KINETICS; MALE; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SHEEP; TIME FACTORS;

EID: 34447526067     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609883200     Document Type: Article

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