Quantitative trait locus that determines the cross-sectional shape of the femur in SAMP6 and SAMP2 mice

Journal of Bone and Mineral Research

Volumn 22, Issue 5, 2007, Pages 675-685

  Otsuki, Bungo ^a   Matsumura, Takuro ^b   Shimizu, Motoyuki ^c   Mori, Masayuki ^d   Okudaira, Shuzo ^e   Nakanishi, Rika ^a   Higuchi, Keiichi ^d   Hosokawa, Masanori ^f   Tsuboyama, Tadao ^a   Nakamura, Takashi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b HAMAMATSU ROSAI HOSPITAL   (Japan)

^c UTANO NATIONAL HOSPITAL   (Japan)

^d SHINSHU UNIVERSITY   (Japan)

^e KYOTO CITY HOSPITAL   (Japan)

^f INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

Author keywords

Bone histomorphometry; Bone modeling; Bone shape; Congenic mouse strain; Senescence accelerated mouse

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE GROWTH; BONE MASS; BONE MINERAL; BONE STRUCTURE; CACNG4 GENE; CHROMOSOME 11; CONGENIC STRAIN; CONTROLLED STUDY; CORTICAL BONE; FEMUR; GENE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE LOCUS; IMAGE ANALYSIS; MALE; MICRO-COMPUTED TOMOGRAPHY; MORPHOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PBD1 GENE; PERIOSTEUM; PHENOTYPE; QUANTITATIVE TRAIT LOCUS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; THICKNESS; UNINDEXED SEQUENCE; ANIMAL; BONE DENSITY; CHROMOSOME; CHROMOSOME MAP; GENETICS; HISTOLOGY; PHYSIOLOGY;

CACNG4 PROTEIN, MOUSE; CALCIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMALS; BONE DENSITY; CALCIUM CHANNELS; CHROMOSOME MAPPING; CHROMOSOMES; FEMUR; MALE; MICE; MICE, CONGENIC; QUANTITATIVE TRAIT LOCI;

EID: 34447522109     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070206     Document Type: Article

References (36)

1. Volkman SK, Galecki AT, Burke DT, Paczas MR, Moalli MR, Miller RA, Goldstein SA 2003 Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population. J Bone Miner Res 18:1497-1505.
2. Pouilles JM, Bernard J, Tremollieres F, Louvet JP, Ribot C 1989 Femoral bone density in young male adults with stress fractures. Bone 10:105-108.
3. Bouxsein ML 2005 Determinants of skeletal fragility. Best Pract Res Clin Rheumatol 19:897-911.
4. Bouxsein ML, Coan BS, Lee SC 1999 Prediction of the strength of the elderly proximal femur by bone mineral density and quantitative ultrasound measurements of the heel and tibia. Bone 25:49-54.
5. Lochmuller EM, Groll O, Kuhn V, Eckstein F 2002 Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius. Bone 30:207-216.
6. Lochmuller EM, Lill CA, Kuhn V, Schneider E, Eckstein F 2002 Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites. J Bone Miner Res 17:1629-1638.
7. Muller ME, Webber CE, Bouxsein ML 2003 Predicting the failure load of the distal radius. Osteoporos Int 14:345-352.
8. Skaggs DL, Loro ML, Pitukcheewanont P, Tolo V, Gilsanz V 2001 Increased body weight and decreased radial cross-sectional dimensions in girls with forearm fractures. J Bone Miner Res 16:1337-1342.
9. Takeda T, Hosokawa M, Takeshita S, Irino M, Higuchi K, Matsushita T, Tomita Y, Yasuhira K, Hamamoto H, Shimizu K, Ishii M, Yamamuro T 1981 A new murine model of accelerated senescence. Mech Ageing Dev 17:183-194.
10. Shimizu M, Higuchi K, Bennett B, Xia C, Tsuboyama T, Kasai S, Chiba T, Fujisawa H, Kogishi K, Kitado H, Kimoto M, Takeda N, Matsushita M, Okumura H, Serikawa T, Nakamura T, Johnson TE, Hosokawa M 1999 Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm Genome 10:81-87.
11. Benes H, Weinstein RS, Zheng W, Thaden JJ, Jilka RL, Manolagas SC, Shmookler Reis RJ 2000 Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains. J Bone Miner Res 15:626-633.
12. Yershov Y, Baldini TH, Villagomez S, Young T, Martin ML, Bockman RS, Peterson MG, Blank RD 2001 Bone strength and related traits in HcB/Dem recombinant congenic mice. J Bone Miner Res 16:992-1003.
13. Shultz KL, Donahue LR, Bouxsein ML, Baylink DJ, Rosen CJ, Beamer WG 2003 Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density. J Bone Miner Res 18:175-185.
14. Masinde GL, Wergedal J, Davidson H, Mohan S, Li R, Li X, Baylink DJ 2003 Quantitative trait loci for periosteal circumference (PC): Identification of single loci and epistatic effects in F2 MRL/SJL mice. Bone 32:554-560.
15. Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill GA, Muller R, Beamer WG 2004 Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Miner Res 19:587-599.
16. Volkman SK, Galecki AT, Burke DT, Miller RA, Goldstein SA 2004 Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse population. J Bone Miner Res 19:1497-1505.
17. Lang DH, Sharkey NA, Mack HA, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, McClearn GE 2005 Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res 20:88-99.
18. Wergedal JE, Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ 2006 Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry. J Bone Miner Res 21:1256-1266.
19. Klein RF, Allard J, Avnur Z, Nikolcheva T, Rotstein D, Carlos AS, Shea M, Waters RV, Belknap JK, Peltz G, Orwoll ES 2004 Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 303:229-232.
20. Shimizu M, Higuchi K, Kasai S, Tsuboyama T, Matsushita M, Mori M, Shimizu Y, Nakamura T, Hosokawa M 2001 Chromosome 13 locus, Pbd2, regulates bone density in mice. J Bone Miner Res 16:1972-1982.
21. Aoyama T, Nagayama S, Okamoto T, Hosaka T, Nakamata T, Nishijo K, Tsuboyama T, Nakayama T, Nakamura T, Toguchida J 2002 Mutation analyses of the NFAT1 gene in chondrosarcomas and enchondromas. Cancer Lett 186:49-57.
22. Matsushita M, Tsuboyama T, Kasai R, Okumura H, Yamamuro T, Higuchi K, Kohno A, Yonezu T, Utani A 1986 Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. Am J Pathol 125:276-283.
23. Tsuboyama T, Takahashi K, Matsushita M, Okumura H, Yamamuro T, Umezawa M, Takeda T 1989 Decreased endosteal formation during cortical bone modelling in SAM-P/6 mice with a low peak bone mass. Bone Miner 7:1-12.
24. Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR 1987 Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 2:595-610.
25. Yonezu H, Takata S, Shibata A 2004 Effects of unilateral sciatic neurectomy on growing rat femur as assessed by peripheral quantitative computed tomography, Fourier transform infrared spectroscopy and bending test. J Med Invest 51:96-102.
26. Nakanishi R, Shimizu M, Mori M, Akiyama H, Okudaira S, Otsuki B, Hashimoto M, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T 2006 Secreted Frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice. J Bone Miner Res 21:1713-1721.
27. Radeff JM, Singh AT, Stern PH 2004 Role of protein kinase A, phospholipase C and phospholipase D in parathyroid hormone receptor regulation of protein kinase Calpha and interleukin-6 in UMR-106 osteoblastic cells. Cell Signal 16:105-114.
28. Dossing DA, Radeff JM, Sanders J, Lee SK, Hsieh MR, Stern PH 2001 Parathyroid hormone stimulates translocation of protein kinase C isozymes in UMR-106 osteoblastic osteosarcoma cells. Bone 29:223-230.
29. Perez-Castrillon JL, Silva J, Justo I, Sanz A, Martin-Luquero M, Igea R, Escudero P, Pueyo C, Diaz C, Hernandez G, Duenas A 2003 Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: Relationship with angiotensin converting enzyme polymorphisms. Am J Hypertens 16:453-459.
30. Sakuma-Zenke M, Sakai A, Nakayamada S, Kunugita N, Tabata T, Uchida S, Tanaka S, Mori T, Nakai K, Tanaka Y, Nakamura T 2005 Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading. J Bone Miner Res 20:1002-1010.
31. Koller DL, Liu G, Econs MJ, Hui SL, Morin PA, Joslyn G, Rodriguez LA, Conneally PM, Christian JC, Johnston CC Jr, Foroud T, Peacock M 2001 Genome screen for quantitative trait loci underlying normal variation in femoral structure. J Bone Miner Res 16:985-991.
32. Duncan EL, Brown MA, Sinsheimer J, Bell J, Carr AJ, Wordsworth BP, Wass JA 1999 Suggestive linkage of the parathyroid receptor type 1 to osteoporosis. J Bone Miner Res 14:1993-1999.
33. Frost HM 1982 Mechanical determinants of bone modeling. Metab Bone Dis Relat Res 4:217-229.
34. Leblond CP, Wilkinson GW, Belanger LF, Robichon J 1950 Radio-autographic visualization of bone formation in the rat. Am J Anat 86:289-341.
35. Sontag W 1986 Quantitative measurements of periosteal and cortical-endosteal bone formation and resorption in the mid-shaft of male rat femur. Bone 7:63-70.
36. Sontag W 1986 Quantitative measurement of periosteal and cortical-endosteal bone formation and resorption in the mid-shaft of female rat femur. Bone 7:55-62.