Efficient synthesis of the immunomodulating compound KRP-203

Synthesis

Volumn , Issue 13, 2007, Pages 1927-1929

  Hamada, Maiko ^a   Kiuchi, Masatoshi ^a   Adachi, Kunitomo ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Cross coupling; FTY720; KRP 203; Palladium; Synthesis

Indexed keywords

BENZYLATION; CHEMOSELECTIVITY; CHLORINE SUBSTITUENTS; CROSS-COUPLING; KRP-203;

IMMUNOLOGY; PALLADIUM COMPOUNDS; REACTION KINETICS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

COMPLEXATION;

2 AMINO 2 {2 [4 (3 BENZYLOXYPHENYLTHIO) 2 CHLOROPHENYL]ETHYL}PROPAN 1,3 DIOL HYDROCHLORIDE; 3 HYDROXYTHIOPHENOL; ACETAMIDE DERIVATIVE; BROMIDE; CHLORINE; FINGOLIMOD; HYDROXYL GROUP; IMMUNOMODULATING AGENT; KRP 203; N {1,1 BIS(ACETOXYMETHYL) 3 [2 CHLORO 4 (3 HYDOXYPHENYL THIO)PHENYL]PROPHYL}ACETAMIDE; N {3 [4 (3 BENZYLOXYPHENYLTHIO) 2 CHLOROPHENYL] 1,1 BIS(ACETOXYMETHYL)PROPHYL}ACETAMIDE; PALLADIUM; PHENOL DERIVATIVE; SILICA GEL; UNCLASSIFIED DRUG;

ARTICLE; BENZYLATION; COLUMN CHROMATOGRAPHY; COUPLING FACTOR; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETER; NUCLEAR MAGNETIC RESONANCE;

EID: 34447517368     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-983721     Document Type: Article

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