Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid

European Journal of Medicinal Chemistry

Volumn 42, Issue 8, 2007, Pages 1059-1068

  Conti, Paola ^a   Caligiuri, Antonio ^a   Pinto, Andrea ^a   Roda, Gabriella ^a   Tamborini, Lucia ^a   Nielsen, Birgitte ^b   Madsen, Ulf ^b   Frydenvang, Karla ^b   Colombo, Alessio ^a   De Micheli, Carlo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Glutamic acid homologues; Ionotropic glutamate receptors; Isoxazoline derivatives; Spirocyclic compounds

Indexed keywords

2 AMINO 4 PHOSPHONOMETHYL 3 HEPTENOIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMATE RECEPTOR; GLUTAMIC ACID; ISOXAZOLINE DERIVATIVE; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRILE OXIDE; PROLINE; PROPANE; RADIOLIGAND;

AMINO ACID SYNTHESIS; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CYCLOADDITION; DRUG MECHANISM; NONHUMAN; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIC MIXTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; PROTEIN BINDING; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447511276     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.01.013     Document Type: Article

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