Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

Journal of Medicinal Chemistry

Volumn 47, Issue 27, 2004, Pages 6740-6748

  Conti, Paola ^a   De Amici, Marco ^a   Grazioso, Giovanni ^a   Roda, Gabriella ^a   Negra, Federico F Barberis ^a   Nielsen, Birgitte ^b   Stensbøl, Tine B ^b   Madsen, Ulf ^b   Bräuner Osborne, Hans ^b   Frydenvang, Karla ^b   De Sarro, Giovambattista ^c   Toma, Lucio ^d   De Micheli, Carlo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINO 2 CARBOXYETHYL) 5,5 DIMETHYL 4,5 DIHYDROISOXAZOLE 3 CARBOXYLIC ACID; 5 (2 AMINO 2 CARBOXYETHYL) 4,5 DIHYDROISOXAZOLE 3 CARBOXYLIC ACID; AMPA RECEPTOR; CARBOXYLIC ACID DERIVATIVE; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CATATONIA; CHO CELL; CONTROLLED STUDY; CYCLOADDITION; DIASTEREOISOMER; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HALLUCINATION; HUMAN; HYPERTENSION; IN VIVO STUDY; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; SIDE EFFECT; STEREOISOMERISM;

ANIMALS; DRUG DESIGN; MALE; MICE; MICE, INBRED DBA; MOLECULAR CONFORMATION; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19944427093     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049409f     Document Type: Article

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