Synthesis of 3,8,9-trisubstituted-1,7,9-triaza-fluorene-6-carboxylic acid derivatives as a new class of insulin secretagogues

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 17, 2007, Pages 5950-5964

  Bahekar, Rajesh H ^a   Jain, Mukul R ^a   Jadav, Pradip A ^a   Goel, Ashish ^a   Patel, Dipam N ^a   Prajapati, Vijay M ^a   Gupta, Arun A ^a   Modi, Honey ^a   Patel, Pankaj R ^a  

^a ZYDUS RESEARCH CENTRE   (India)

Author keywords

Carboline; Harmane; I3 receptor; Insulin secretion; Triazafluorene; Type 2 diabetes

Indexed keywords

8 BENZYL 3,9 DIMETHYL 9H 1,7,9 TRIAZA FLUORENE 6 CARBOXYLIC ACID; BENZENE DERIVATIVE; BETA CARBOLINE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; FLUORENE DERIVATIVE; GLUCOSE; HARMAN; INSULIN; PYRIDINE DERIVATIVE; SULFONYLUREA; TOLBUTAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; GLUCOSE TOLERANCE TEST; IN VITRO STUDY; INSULIN LIKE ACTIVITY; INSULIN RELEASE; NONHUMAN; RAT; REACTION ANALYSIS;

ANIMALS; BINDING SITES; CARBOXYLIC ACIDS; GLUCOSE; INSULIN; MOLECULAR STRUCTURE; RABBITS; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447342002     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.075     Document Type: Article

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