Bipolar disorder and epilepsy: A bidirectional relation? Neurobiological underpinnings, current hypotheses, and future research directions

Neuroscientist

Volumn 13, Issue 4, 2007, Pages 392-404

  Mazza, Marianna ^a,b   Di Nicola, Marco ^a   Marca, Giacomo Della ^a   Janiri, Luigi ^a   Bria, Pietro ^a   Mazza, Salvatore ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b NONE   (Italy)

Author keywords

Bipolar disorder; Epilepsy; Ion channels; Kindling; Mania; Neurotransmitters; Second messengers

Indexed keywords

ALANINE; ANTICONVULSIVE AGENT; ARIPIPRAZOLE; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; CALCIUM; CALCIUM ANTAGONIST; CARBAMAZEPINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; ETIRACETAM; GABAPENTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HALOPERIDOL; ION CHANNEL; LAMOTRIGINE; LITHIUM; MOOD STABILIZER; NEUROTRANSMITTER; OXCARBAZEPINE; PHENYTOIN; PHOSPHATIDYLINOSITOL; PREGABALIN; PROTEIN C FOS; PROTEIN KINASE C; RETIGABINE; TIAGABINE; TOPIRAMATE; UNINDEXED DRUG; VALPROIC ACID; ZONISAMIDE;

BIPOLAR DEPRESSION; BIPOLAR DISORDER; CHEMICAL ANALYSIS; COMORBIDITY; DEPRESSION; ENZYME SUBSTRATE; EPILEPSY; HUMAN; HYPOTHESIS; KINDLING; MANIA; MEDICAL LITERATURE; MEDICAL RESEARCH; MOOD DISORDER; NEUROBIOLOGY; NEUROIMAGING; NEUROPSYCHIATRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SECOND MESSENGER; SEIZURE;

ANIMALS; BIOMEDICAL RESEARCH; BIPOLAR DISORDER; BRAIN; EPILEPSY; HUMANS; MODELS, BIOLOGICAL; NEUROBIOLOGY;

EID: 34447339107     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/10738584070130041101     Document Type: Review

References (83)

1. Adler CM, DelBello M., Jarvis K., Levine A., Adams J., Strakowski SM 2007. Voxel-based study of structural changes in first-episode patients with bipolar disorder. Biol Psychiatry 61: 776 - 81.
2. Amann B., Grunze H. 2005. Neurochemical underpinnings in bipolar disorder and epilepsy. Epilepsia 46: 26 - 30.
3. Barry JJ 2003. The recognition and management of mood disorders as a comorbidity of epilepsy. Epilepsia 44: 30 - 40.
4. American Psychiatric Association. 2004. Diagnostic and statistical manual of mental disorders. 4 th ed. Washington, DC: American Psychiatric Association.
5. Bauer M., Pfenning A. 2005. Epidemiology of bipolar disorders. Epilepsia 46: 8 - 13.
6. Benes FM, Vincent SL, Todtenkopf M. 2001. The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biol Psychiatry 50: 395 - 406.
7. Berkovic SF, Mulley J., Scheffer IE, Petrou S. 2006. Human epilepsies: interaction of genetic and acquired factors. Trends Neurosci 29: 391 - 7.
8. Blumer D., Altshuler LL 1998. Affective disorders. In: Engel J, Pedley TA, editors. Epilepsy: a comprehensive textbook. Philadelphia: Lippincott Raven. p 2083 - 99.
9. Blumer D., Montouris G., Hermann BP 1995. Psychiatric morbidity in seizure patients on a neurodiagnostic monitoring unit. J Neuropsychiatry Clin Neurosci 7: 445 - 56.
10. Carran MA, Kohler Cg, O'Connor. 2003. Mania following temporal lobectomy. Neurology 61: 770 - 4.
11. Chang K., Adleman N., Dienes K., Barnea-Goraly N., Reiss A., Ketter T. 2003. Decreased N-acetylaspartate in children with familial bipolar disorder. Biol Psychiatry 53: 1059 - 65.
12. Chen G., Manji HK 2006. The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers. Curr Opin Psychiatry 19: 313 - 23.
13. Chen G., Zeng WZ, Yuan PX, Huang LD, Jiang YM, Zhao ZH, and others. 1999. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein Bcl-2 in the CNS. J Neurochem 72: 879 - 82.
14. Chen RW, Chuang DM 1999. Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression: a prominent role in neuroprotection against excitotoxicity. J Biol Chem 274: 6039 - 42.
15. Chen Y., Lu J., Pan H., Zhang Y., Wu H., Xu K., and others. 2003. Association between genetic variation of CACNA1H and childhood absence epilepsy. Ann Neurol 54: 239 - 43.
16. Clark M., Post RM, Weiss SR, Cain CJ, Nakajima T. 1991. Regional expression of c-fos mRNA in rat brain during the evolution of amygdala kindled seizures. Brain Res Mol Brain Res 11: 55 - 64.
17. Dibbens LM, Feng HJ, Richards MC, Harkin LA, Hodgson BL, Scott D., and others. 2004. GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies. Hum Mol Genet 13: 1315 - 9.
18. Diehl DJ, Gershon S. 1992. The role of dopamine in mood disorders. Compr Psychiatry 33: 115 - 20.
19. Dubovsky SL, Thomas M., Hijazi A. 1994. Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder. Neuropsychobiology 27: 122 - 6.
20. Eastwood SL, Harrison PJ 2000. Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of the complexin mRNAs. Mol Psychiatry 5: 425 - 32.
21. Einat H., Manji HK 2006. Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder. Biol Psychiatry 59: 1160 - 71.
22. Ettinger AB 2006. Psychotropic effects of antiepileptic drugs. Neurology 67: 1916 - 25.
23. Ettinger AB, Reed ML, Goldberg JF, Hirshfield MA 2005. Prevalence of bipolar symptoms in epilepsy vs other chronic health disorders. Neurology 65: 535 - 40.
24. Flor-Henry P. 1969. Psychosis and temporal-lobe epilepsy: a controlled investigation. Epilepsia 10: 363 - 95.
25. Ghaemi SN, Boiman EE, Goodwin FK 1999. Kindling and second messengers: an approach to the neurobiology of recurrence in bipolar disorder. Biol Psychiatry 45: 137 - 44.
26. Gilbert ME 2001. Does the kindling model of epilepsy contribute to our understanding of multiple chemical sensitivity? Ann N Y Acad Sci 933: 68 - 91.
27. Goddard GV, McIntyre DC, Leech CK 1969. A permanent change in brain function resulting from daily electrical stimulation. Expert Neurol 25: 295 - 330.
28. Goldberg JF, Harrow M. 1994. Kindling in bipolar disorders: a longitudinal follow-up study. Biol Psychiatry 35: 70 - 2.
29. Grunze H., Amann B., Walden J. 2002. How might anticonvulsant drugs work in bipolar affective disorder ? In: Trimble M, Schmitz B, editors. Seizures, affective disorders and anticonvulsant drugs. Guilford, UK: Clarius.
30. Guidotti A., Auta J., Davis JM, Gerevini VD, Dwivedi Y., Grayson DR, and others. 2000. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch Gen Psychiatry 57: 1061 - 9.
31. Hauser WA, Kurland LT 1993. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 34: 453 - 68.
32. Hurwitz TA, Wada JA, Kosaka BA, Strauss EH 1985. Cerebral organization of affect suggested by temporal lobe seizures. Neurology 35: 1335 - 7.
33. Jagadheesan K., Garg AK, Nizamie SH 2003. Risk factors and outcome of mood disorders in epilepsy: a case-control study. Seizure 12: 121 - 5.
34. Jimerson DC, Nurnberger JI, Post RM, Gershon ES, Kopin IJ 1981. Plasma MHPG in rapid cyclers and healthy twins. Arch Gen Psychiatry 38: 1287 - 90.
35. Jobe PC 2003. Common pathogenic mechanisms between depression and epilepsy: an experimental perspective. Epilepsy Behav 4: S14 - 24.
36. Jobe PC 2004. Affective disorder and epilepsy comorbidity: implications for development of treatments, preventions and diagnostic approaches. Clin EEG Neurosci 35: 53 - 68.
37. Johnston-Wilson NL, Sims CD, Hofmann JP, Anderson L., Shore AD, Torrey EF, and others. 2000. Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium. Mol Psychiatry 5: 142 - 9.
38. Kanemoto K., Kawasaki J., Kawai I. 1996. Postictal psychosis: a comparison with acute interictal and chronic psychoses. Epilepsia 37: 551 - 6.
39. Kanner AM 2004. Is major depression a neurologic disorder with psychiatric symptoms? Epilepsy Behav 5: 636 - 44.
40. Kanner AM, Balabanov A. Depression and epilepsy: how closely related are they ? Neurology 58 (suppl 5). 27 - 39.
41. Ketter TA, Kimbrell TA, George MS, Dunn RT, Speer AM, Benson BE, and others. 2001. Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder. Biol Psychiatry 49: 97 - 109.
42. Kling MA, Roy A., Doran AR, Calabrese JR, Rubinow DR, Whitfield Hjj, and others. 1991. Cerebrospinal fluid immunoreactive corticotropinreleasing hormone and adrenocorticotropin secretion in Cushings disease and major depression: potential clinical implications. J Clin Endocrinol Metab 72: 260 - 71.
43. Knable MB, Torrey EF, Webster MJ, Bartko JJ 2001. Multivariate analysis of prefrontal cortical data from the Stanley Foundation Neuropathology Consortium. Brain Res Bull 55: 651 - 9.
44. Kudo T., Ishida S., Kubota H., Yagi K. 2001. Manic episode in epilepsy and bipolar I disorder: a comparative analysis of 13 patients. Epilepsia 42: 1036 - 42.
45. Kupka R., Post R. 2002. Kindling as a model for affective disorders. In: Trimble M, Schmitz B, editors. Seizures, affective disorders and anticonvulsant drugs. Guilford, UK: Clarius.
46. Landolt H. 1958. Serial electroencephalographic investigations during psychotic episodes in epileptic patients and during schizophrenic attacks. In: Lorentz de Haas AM, editor. Lectures on epilepsy. Amsterdam: Elsevier. p 91 - 133.
47. Manji HK, Potter WZ, Lenox RH 1995. Signal transduction pathways: molecular targets for lithium's actions. Arch Gen Psychiatry 52: 531 - 43.
48. Mazza M., Bria P., Janiri L., Mazza S. 2006. Neuroendocrinologia dei disturbi dell'umore. Minerva Psichiatrica 47: 11 - 24.
49. Mazza M., Orsucci F., De Risio S., Bria P., Mazza S. 2004 a. Epilepsy and depression: risk factors for suicide ? Clinica Terapeutica 155: 425 - 7.
50. Mazza M., Satta MA, Bria P., Mazza S. 2004 b. Neuroendocrinology of mood disorders. Clinica Terapeutica 155: 537 - 41.
51. Miguel-Hidalgo JJ, Baucom C., Dilley G., Overholser JC, Meltzer HY, Stockmeier CA, and others. 2000. Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder. Biol Psychiatry 48: 861 - 73.
52. Morimoto K., Fahnestock M., Racine RJ 2004. Kindling and status epilepticus models of epilepsy: rewiring the brain. Prog Neurobiol 73: 1 - 60.
53. Mula M., Monaco F. 2006. Antiepileptic drug-induced mania in patients with epilepsy: what do we know? Epilepsy Behav 9: 265 - 7.
54. Mulley JC, Scheffer IE, Harkin LA, Berkovic SF, Dibbens LM 2005. Susceptibility genes for complex epilepsy. Hum Mol Genet 14: 243 - 9.
55. Mulley JC, Scheffer IE, Petrou S., Dibbens LM, Berkovic SF, Harkin LA 2005 a. SCN1A mutations in epilepsy. Hum Mutat 25: 535 - 42.
56. Muzina DJ, Elhaj O., Gajwani P., Gao K., Calabrese JR 2005 b. Lamotrigine and antiepileptic drugs as mood stabilizers in bipolar disorder. Acta Psychiatr Scand Suppl 426: 21 - 8.
57. Nishida T., Kudo T., Inoue Y., Nakamura F., Yoshimura M., Matsuda K., and others. 2006. Postictal mania versus postictal psychosis: differences in clinical features, epileptogenic zone, and brain functional changes during postictal period. Epilepsia 47: 2104 - 14.
58. Nishida T., Kudo T., Nakamura F., Yoshimua M., Matsuda K., Yagi K. 2005. Postictal mania associated with frontal lobe epilepsy. Epilepsy Behav 6: 102 - 10.
59. Nonaka S., Katsube N., Chuang DM 1998. Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine. J Pharmacol Expert Ther 286: 539 - 47.
60. Ongur D., Drevets W., Price JL 1998. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 95: 13290 - 5.
61. Paciello N., Mazza M., Mazza S. 2002. Depression and epilepsy: symptom or syndrome ? Clinica Terapeutica 153: 397 - 402.
62. Post R., Weiss S., Smith M., Rosen J., Frye M. 1995. Stress, conditioning, and the temporal aspects of affective disorders. Biol Psychiatry 771: 677 - 96.
63. Post RM 2004. Neurobiology of seizures and behavioral abnormalities. Epilepsia 45 (suppl 2). 5 - 14.
64. Post RM, Denicoff KD, Leverich GS, Huggins T., Post SW, Luckenbaugh D. 2000 a. Neuropsychological deficits of primary affective illness: implications of therapy. Psychiatry Ann 30: 485 - 94.
65. Post RM, Speer AM, Hough CJ, Xing G. 2003. Neurobiology of bipolar illness: implications for future study and therapeutics. Ann Clin Psychiatry 15: 85 - 94.
66. Post RM, Speer AM, Weiss SR, Li H. 2000 b. Seizure models: anticonvulsant effects of ECT and rTMS. Prog Neuropsychopharmacol Biol Psychiatry 24: 1251 - 73.
67. Post RM, Weiss Srb. 1997. Kindling and stress sensitization. In: Young LT, Joffe RT, editors. Bipolar disorder: biological models and their clinical application. New York: Marcel Dekker. p 93 - 126.
68. Qin P., Xu H., Laursen TM, Vestergaard M., Mortensen PB 2005. Risk for schizophrenia and schizophrenia-like psychosis among patients with epilepsy: population based cohort study. BMJ 331: 23.
69. Rajkowska G. 2000. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biol Psychiatry 48: 766 - 77.
70. Rubinow DR, Gold PW, Post RM, Ballenger JC, Cowdry R., Bollinger J., and others. 1983. CSF somatostatin in affective illness. Arch Gen Psychiatry 40: 409 - 12.
71. Rubinow DR, Post RM, Pickar D., Naber D., Ballenger JC, Gold PW, and others. 1981. Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers. Psychiatry Res 5: 87 - 93.
72. Schmitz B. 2005. Depression and mania in patients with epilepsy. Epilepsia 46 (suppl 4). 45 - 9.
73. Schurhoff F., Bellivier F., Jouvent R., Mouren-Simeoni MC, Bouvard M., Allilaire JF, and others. 2000. Early and late onset bipolar disorders: two different forms of manic-depressive illness? J Affect Disord 58: 215 - 21.
74. Smoller JW, Finn CT 2003. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet 123C: 48 - 58.
75. Speckmann EJ, Straub H., Kohling R. 1993. Contribution of calcium ions to the generation of epileptic activity and antiepileptic calcium antagonism. Neuropsychobiology 27: 122 - 6.
76. Sporn J., Sachs G. 1997. The anticonvulsant lamotrigine in treatment-resistant manic-depressive illness. J Clin Psychopharmacol 17: 185 - 9.
77. Starkstein SE, Boston JD, Robinson RG 1988. Mechanisms of mania after brain injury: 12 case reports and review of the literature. J Nerv Mental Dis 176: 87 - 100.
78. Strober M., Morrell W., Burroughs J., Lampert C., Danforth H., Freeman R. 1988. A family study of bipolar I disorder in adolescence: early onset of symptoms linked to increased familial loading and lithium resistance. J Affect Disord 15: 255 - 68.
79. Weisler RH, Cutler AJ, Ballenger JC, Post RM, Ketter TA 2006. The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials. CNS Spectr 11: 788 - 99.
80. Wolf P. 1982. Manic episodes in epilepsy. In: Akimoto H, Kazamatsuri H, Seino M, Ward A, editors. Advances in epileptology: XIIIth Epilepsy International Symposium. New York: Raven. p 237 - 40.
81. Xing GQ, Russell S., Hough C., O'Grady J., Zhang L., Yang S., and others. 2002. Decreased prefrontal CaMKII α mRNA in bipolar illness. Neuroreport 13: 501 - 5.
82. Yatham LN, Liddle PF, Shiah IS 2002. PET study of [(18)F]6-fluoro-L-dopa uptake in neuroleptic- and mood-stabilizer-naive first-episode nonpsychotic mania: effects of treatment with divalproex sodium. Am J Psychiatry 159: 768 - 74.
83. Yuan PX, Huang LD, Jiang YM 2001. The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth. J Biol Chem 276: 31674 - 83.