Impact of cell culture process changes on endogenous retrovirus expression

Biotechnology and Bioengineering

Volumn 80, Issue 3, 2002, Pages 257-267

  Brorson, Kurt ^a   De Wit, Christina ^b   Hamilton, Elizabeth ^a   Mustafa, Mehnaz ^a   Swann, Patrick G ^a   Kiss, Robert ^b   Taticek, Ron ^b   Polastri, Gian ^b   Stein, Kathryn E ^a   Xu, Yuan ^b  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b GENENTECH INC   (United States)

Author keywords

Cell culture process changes; Quantitave PCR; Retrovirus expression; Viral safety

Indexed keywords

ANTIBODIES; BIOSYNTHESIS; CELL CULTURE; LIFE CYCLE; METABOLISM;

CELL LINES;

BIOTECHNOLOGY;

BUTYRIC ACID; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ARTICLE; CELL CULTURE; CELL LINE; CELL METABOLISM; CHO CELL; CULTURE MEDIUM; DENSITY; NUTRIENT; PH; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PURIFICATION; RETROVIRUS; TEMPERATURE; VIRUS EXPRESSION;

ANIMALS; ANTIBODIES, MONOCLONAL; BUTYRATES; CELL CULTURE TECHNIQUES; CELL LINE; CHO CELLS; CRICETINAE; ENDOGENOUS RETROVIRUSES; GENE EXPRESSION REGULATION, VIRAL; HYDROGEN-ION CONCENTRATION; OXYGEN; POLYMERASE CHAIN REACTION; QUALITY CONTROL; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TEMPERATURE;

CRICETINAE; CRICETULUS GRISEUS; UNIDENTIFIED RETROVIRUS;

EID: 0037027379     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10366     Document Type: Article

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