Concurrent high expression of human telomerase reverse transcriptase and human nonmetastatic clone 23 in high-grade squamous intraepithelial neoplasia and squamous cell carcinoma of uterine cervix

International Journal of Gynecological Cancer

Volumn 17, Issue 4, 2007, Pages 851-857

  Hsu, C G ^a,b   Wang, P H ^c   Ko, J L ^a   Chen, G D ^a   Chang, H ^a   Yang, S F ^a   Chen, S C ^c   Lin, L Y ^a  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b Da Chien General Hospital   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Correlation; High grade cervical intraepithelial neplasia; Human nonmetastatic clone 23; Human telomerase reverse transcriptase; Squamous cell carcinoma

Indexed keywords

TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER TISSUE; CARCINOGENESIS; CHI SQUARE TEST; CLONE; CONTROLLED STUDY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; FEMALE; FISHER EXACT TEST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MOLECULAR BIOLOGY; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAMPLE; SENSITIVITY AND SPECIFICITY; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; UTERINE CERVIX CARCINOMA IN SITU;

CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM METASTASIS; NEOPLASM STAGING; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; SENSITIVITY AND SPECIFICITY; TELOMERASE; UTERINE CERVICAL NEOPLASMS;

EID: 34447325128     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2007.00894.x     Document Type: Article

References (35)

1. Richart RM, Barron BA. A follow-up of patients with cervical dysplasia. Am J Obstet Gynecol 1969 105: 386 93.
2. Richart RM. Cervical intraepithelial neoplasia. Pathol Annu 1973 18: 301 28.
3. National Cancer Institute Workshop. The 1988 Bethesda system for reporting cervical/vaginal cytological diagnoses. JAMA 1989 262: 931 4.
4. Pinto AP, Crum CP. Natural history of cervical neoplasia: defining progression and its consequence. Clin Obstet Gynecol 2000 45: 352 62.
5. Mitchell MF, Tortolero-Luna G, Wright T et al. Cervical human papillomavirus infection and intraepithelial neoplasia: a review. J Natl Cancer Inst Monographs 1996 21: 17 25.
6. Greider CW. Telomere length regulation. Annu Rev Biochem 1996 65: 337 65.
7. Shay JW, Bacchetti S. Telomerase activity in human cancer. Eur J Cancer 1997 33: 787 91.
8. Harle-Bachor C, Boukamp P. Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc Natl Acad Sci 1996 93: 6476 81.
9. Norrback KF, Roos G. Telomeres and telomerase activity in normal and malignant haematopoietic cells. Eur J Cancer 1997 33: 774 80.
10. Feng J, Funk WD, Wang SS et al. The RNA component of human telomerase. Science 1995 269: 1236 41.
11. Harrington L, McPhail T, Mar V et al. A mammalian telomerase-associated protein. Science 1997 275: 973 7.
12. Nakamura TM, Morin GB, Chapman KB et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997 277: 955 9.
13. Meyerson M, Counter CM, Eaton EN et al. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997 90: 785 95.
14. Counter CM, Meyerson M, Eaton EN et al. Telomerase activity is restored in human cells by ectopic expression hTERT (hEST2), the catalytic subunit of temomerase. Oncogene 1998 16: 1217 22.
15. Weinrich SL, Pruzan R, Ma L et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997 17: 498 502.
16. Yashima K, Litzky LA, Kaiser L et al. Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas. Cancer Res 1997 57: 2373 7.
17. Blasco MA, Rizen M, Greider CW, Hanahan D. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet 1996 12: 200 4.
18. Wisman GB, De Jong S, Meersma GJ et al. Telomerase in (pre)neoplastic cervical disease. Hum Pathol 2000 31: 1304 12.
19. Frost M, Bobak JB, Gianani R et al. Localization of telomerase hTERT protein and hTR in benign mucosa, dysplasia, and squamous cell carcinoma of the cervix. Am J Clin Pathol 2000 114: 726 34.
20. Steeg PS, Bevilacqua G, Kopper L et al. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988 80: 200 4.
21. Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO. The human nm23/nucleoside diphosphate kinases. J Bioenerg Biomembr 2000 32: 247 58.
22. Lombardi D, Lacombe M, Paggi MG. Nm23: unraveling its biology function in cell differentiation. J Cell Physiol 2000 182: 144 9.
23. Tsuiki H, Nitta M, Furuya A et al. A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis. J Cell Biochem 1999 76: 254 69.
24. Wang PH, Ko JL, Chang H, Lin LY. Clinical significance of high nm23-H1 expression in intraepithelial neoplasia and early-stage squamous cell carcinoma of the uterine cervix. Gynecol Obstet Invest 2003 55: 14 9.
25. Ravazoula P, Aletra C, Kourounis G, Ladopoulos I, Tzigounis V. Immunohistochemical analysis of nm23-H1 expression in human cervical lesions. Eur J Gynaecol Oncol 2000 21: 510 2.
26. Branca M, Giorgi C, Ciotti M et al. Down-regulated nucleoside diphosphate kinase nm23-h1 expression is unrelated to high-risk human papillomavirus but associated with progression of cin and unfavourable prognosis in cervical cancer. J Clin Pathol 2006 59: 1044 51.
27. Liu K, Hodes RH, Weng NP. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J Immunol 2001 166: 4826 30.
28. Akiyama M, Hideshima T, Hayashi T et al. Nuclear factor-κB p65 mediates tumor necrosis factor α-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res 2003 63: 18 21.
29. Nakano K, Watney E, McDougall JK. Telomerase activity and expression of telomerase RNA component and telomerase catalytic subunit gene in cervical cancer. Am J Pathol 1998 153: 857 64.
30. Sagawa Y, Nishi H, Isaka K, Fujito A, Takayama M. The correlation of TERT expression with c-myc expression in cervical cancer. Cancer Lett 2001 168: 45 50.
31. Tsezou A, Oikonomou P, Kollia P et al. The role of human telomerase catalytic Subunit mRNA expression in cervical dyplasias. Exp Biol Med 2005 230: 263 70.
32. Zhang A, Wang J, Zheng B et al. Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix. Oncogene 2004 23: 7441 7.
33. Weber G, Jackson RC, Williams JC, Goulding FJ, Eberts TJ. Enzymatic markers of neoplastic transformation and regulation of purine and pyrimidine metabolism. Adv Enzyme Regul 1977 15: 53 77.
34. Ohneda K, Fukuda M, Shimada N et al. Increased expression of nucleoside diphosphatekinases/nm23 in human diploid fibroblasts transformed by SV40 large T antigen or 60Co irradiation. FEBS Lett 1994 348: 273 7.
35. Bravaccini S, Sanchini MA, Amadori A et al. Potential of telomerase expression and activity in cervical specimens as a diagnostic tool. J Clin Pathol 2005 58: 911 4.