Clinical significance of high nm23-H1 expression in intraepithelial neoplasia and early-stage squamous cell carcinoma of the uterine cervix

Gynecologic and Obstetric Investigation

Volumn 55, Issue 1, 2003, Pages 14-19

  Wang, Po Hui ^a   Ko, Jiunn Liang ^a   Chang, Han ^a   Lin, Long Yau ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cellular proliferation; Cumulative recurrence hazard; Deep stromal invasion; High nm23 H1 expression; High grade cervical intraepithelial neoplasia; Squamous cell carcinoma

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE;

ADULT; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER RECURRENCE; CARCINOGENESIS; CELL PROLIFERATION; DISEASE MARKER; DISEASE SEVERITY; EARLY CANCER; FEMALE; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SQUAMOUS CELL; TISSUE LEVEL; UTERINE CERVIX; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU;

CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MONOMERIC GTP-BINDING PROTEINS; NEOPLASM RECURRENCE, LOCAL; NUCLEOSIDE-DIPHOSPHATE KINASE; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; TRANSCRIPTION FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 0346035744     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000068951     Document Type: Article

References (22)

1. Steeg PS, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JE, Liotta LA, Sobel ME: Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988;80:200-204.
2. Gilles AM, Presecan E, Vcnica A, Lascu I: Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme. J Biol Chem 1991;266:8784-8789.
3. Bevilacqua G, Sobel ME, Liotta LA, Steeg PS: Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph-node involvement and other histopathological indicators of high metastatic potential. Cancer Res 1989;49:5185-5190.
4. Nakayama T, Ohtsuru A, Nakao K, Shima M, Nakata K, Watanabe K, Ishii N, Kimura N, Nagataki S: Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product. J Natl Cancer Inst 1992;84:1349-1354.
5. Konishi N, Nakaoka S, Tsuzuki T, Matsumoto K, Kitahori Y, Hiasa Y, Urano T, Shiku H: Expression of nm23-H1 and nm23-H2 proteins in prostate carcinoma. Jpn J Cancer Res 1993;84:1050-1054.
6. Nakayama H, Yasui W, Yokozaki H, Tohara E: Reduced expression of nm23 is associated with metastasis of human gastric carcinomas. Jpn J Cancer Res 1993;84:184-190.
7. Florenes VA, Aamdal S, Myklebost O, Maelansmo GM, Bruland DS, Fodstad D: Levels of nm23 messenger RNA in metastatic malignant melanomas: Inverse correlation to disease progression. Cancer Res 1992;52:6088-6091.
8. Engel M, Theisinger B, Seib T, Seitz G, Huwer H, Zang KD, Welter C, Dooley S: High levels of nm23-H1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages. Int J Cancer 1993;55:375-379.
9. Haut M, Steeg PS, Willson JKV, Markowitz SD: Induction of nm23 expression in human colonic neoplasms and equal expression in colon tumors of both high and low metastatic potentional. J Natl Cancer Inst 1991;83:712-716.
10. Nakamori S, Ishikawa O, Ohhigashi H, Kameyama M, Furukawa H, Sasaki Y, Inaji H, Higashiyama M, Imaoka S, Iwanaga T, Funai H, Wada A, Kimura N: Expression of nucleoside diphosphate kinase/nm23 gene product in human pancreatic cancer: An association with lymph node metastasis and tumor invasion. Clin Exp Metastasis 1993;11:151-158.
11. Zou M, Shi Y, Al-Sedairy S, Farid NR: High levels of nm23 gene expression in advanced stage of thyroid carcinomas. Br J Cancer 1993; 68:385-388.
12. Marone M, Scambia G, Ferrandina G, Giannitelli C, Benedetti-Panici P, Iacovella S, Leone A, Mancuso S: Nm23 expression in endometrial and cervical cancer: inverse correlation with lymph node involvement and myometrial invasion. Br J Cancer 1996;74:1063-1068.
13. Mandai M, Konishi I, Koshiyama M, Komatsu T, Yamamoto S, Nanbu K, Mori T, Fukumoto M: Altered expression of nm23 H1 and c-erbB-2 proteins have prognostic significance in adenocarcinoma but not in squamous cell carcinoma of the uterine cervix. Cancer 1995;75:2523-2529.
14. Kristensen GB, Holm R, Abeler VM, Trope CG: Evaluation of the prognostic significance of nm23/NDP kinase protein expression in cervical carcinoma: An immunohistochemical study. Gynecol Oncol 1996;61:378-383.
15. Lee CS, Gad J: nm23-H1 protein immunoreactivity in intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Pathol Int 1998;48:806-811.
16. Lacombe ML, Sastre-Garau X, Lascu I, Vonica A, Wallet V, Thiery JP, Veron M: Overexpression of nucleoside diphosphate kinase (nm23) in solid tumors. Eur J Cancer 1991;27:1302-1307.
17. Weber G, Jackson RC, Williams JC, Goulding FJ, Eberts TJ: Enzymatic markers of neoplastic transformation and regulation of purine and pyrimidine metabolism. Adv Enzyme Regul 1977;15:53-77.
18. Kikkawa S, Takahashi K, Takahashi K, Shimada N, Ui M, Kimura N, Katada T: Conversion of GDP into GTP by nucleoside diphosphate kinase on the GTP-binding proteins. J Biol Chem 1990;265:21536-21540.
19. Otero AD: Transphosphorylation and G protein activation. Biochem Pharmacol 1990;39:1399-1404.
20. 60Co irradiation. FEBS Lett 1994;348:273-277.
21. Sarac E, Ayhan A, Ertoy D, Tuncer ZS, Yasui W, Tahara E, Ayhan A: Nm23 expression in carcinoma of the uterine cervix. Eur J Gynaecol Oncol 1998;19:312-315.
22. Chen HY, Hsu CT, Lin WC, Tsai HD, Chang WC: Prognostic value of nm23 expression in Stage IB1 cervical carcinoma. Jpn J Clin Oncol 2001;31:327-332.