메뉴 건너뛰기




Volumn 74, Issue 4, 2007, Pages 639-646

A novel drug interaction between the quinolone antibiotic ciprofloxacin and a chiral metabolite of pentoxifylline

Author keywords

Ciprofloxacin; Drug interaction; Fibrosis; Metabolism; Metabolite 1; Pentoxifylline

Indexed keywords

CIPROFLOXACIN; DRUG METABOLITE; METHYLXANTHINE DERIVATIVE; PENTOXIFYLLINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

EID: 34447283989     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.05.013     Document Type: Article
Times cited : (11)

References (44)
  • 1
    • 0023189396 scopus 로고
    • PTX, a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy
    • Ward A., and Clissold S.P. PTX, a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 34 (1987) 50-97
    • (1987) Drugs , vol.34 , pp. 50-97
    • Ward, A.1    Clissold, S.P.2
  • 3
    • 0035869052 scopus 로고    scopus 로고
    • Treatment of intermittent claudication with pentoxifylline and cilostazol
    • Tjon J.A., and Riemann L.E. Treatment of intermittent claudication with pentoxifylline and cilostazol. Am J Health Sys Pharm 58 (2001) 485-493
    • (2001) Am J Health Sys Pharm , vol.58 , pp. 485-493
    • Tjon, J.A.1    Riemann, L.E.2
  • 7
    • 0028834655 scopus 로고
    • Monocyte-mediated regulation of the antigen-driven IFN gamma production by T cells
    • Mytar B., Woloszyn M., Ruggerio I., Pryjma J., and Zembala M. Monocyte-mediated regulation of the antigen-driven IFN gamma production by T cells. Immunol Invest 24 6 (1995) 897-906
    • (1995) Immunol Invest , vol.24 , Issue.6 , pp. 897-906
    • Mytar, B.1    Woloszyn, M.2    Ruggerio, I.3    Pryjma, J.4    Zembala, M.5
  • 8
    • 0029993357 scopus 로고    scopus 로고
    • Pentoxifylline, a phosphodiesterase inhibitor, induces immune deviation in patients with multiple sclerosis
    • Rieckmann P., Weber F., Gunther A., Martin S., Bitsch A., Brooks A., et al. Pentoxifylline, a phosphodiesterase inhibitor, induces immune deviation in patients with multiple sclerosis. J Neuroimmunol 64 2 (1996) 193-200
    • (1996) J Neuroimmunol , vol.64 , Issue.2 , pp. 193-200
    • Rieckmann, P.1    Weber, F.2    Gunther, A.3    Martin, S.4    Bitsch, A.5    Brooks, A.6
  • 9
    • 0030858931 scopus 로고    scopus 로고
    • Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis
    • Windmeier C., and Gressner A.M. Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen Pharmacol 29 2 (1997) 181-196
    • (1997) Gen Pharmacol , vol.29 , Issue.2 , pp. 181-196
    • Windmeier, C.1    Gressner, A.M.2
  • 10
    • 0030927340 scopus 로고    scopus 로고
    • In vitro effects of oxpentifylline on inflammatory cytokine release in patients with inflammatory bowel disease
    • Reimund J.M., Dumont S., Muller C.D., Kenney J.D., Kedinger M., Baumann R., et al. In vitro effects of oxpentifylline on inflammatory cytokine release in patients with inflammatory bowel disease. Gut 40 4 (1997) 475-480
    • (1997) Gut , vol.40 , Issue.4 , pp. 475-480
    • Reimund, J.M.1    Dumont, S.2    Muller, C.D.3    Kenney, J.D.4    Kedinger, M.5    Baumann, R.6
  • 11
    • 0030907779 scopus 로고    scopus 로고
    • c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation
    • Wang W., Tam W.F., Hughes, Rath S., and Sen R. c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. Immunity 6 2 (1997) 165-174
    • (1997) Immunity , vol.6 , Issue.2 , pp. 165-174
    • Wang, W.1    Tam, W.F.2    Hughes3    Rath, S.4    Sen, R.5
  • 13
    • 0031930455 scopus 로고    scopus 로고
    • Platelet-derived growth factor and pentoxifylline modulation of collagen synthesis in myofibroblasts
    • Isbrucker R.A., and Peterson T.C. Platelet-derived growth factor and pentoxifylline modulation of collagen synthesis in myofibroblasts. Toxicol Appl Pharmacol 149 (1998) 120-126
    • (1998) Toxicol Appl Pharmacol , vol.149 , pp. 120-126
    • Isbrucker, R.A.1    Peterson, T.C.2
  • 14
    • 26544458295 scopus 로고    scopus 로고
    • Effect of pentoxifylline in collagenous colitis
    • Peterson T.C., and Tanton R. Effect of pentoxifylline in collagenous colitis. Can J Gastroenterol 10 (1996) S76
    • (1996) Can J Gastroenterol , vol.10
    • Peterson, T.C.1    Tanton, R.2
  • 15
    • 0029001211 scopus 로고
    • Novel insights into the biology and physiology of the Ito cell
    • Pinzani M. Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther 66 (1995) 387-412
    • (1995) Pharmacol Ther , vol.66 , pp. 387-412
    • Pinzani, M.1
  • 16
    • 0030795195 scopus 로고    scopus 로고
    • Pentoxifylline inhibits growth and collagen synthesis of cultured human myofibroblasts-like cells
    • Preaux A.-M., Mallat A., Rosenbaum J., Zafrani E.-S., and Mauvier P. Pentoxifylline inhibits growth and collagen synthesis of cultured human myofibroblasts-like cells. Hepatology 26 (1997) 315-322
    • (1997) Hepatology , vol.26 , pp. 315-322
    • Preaux, A.-M.1    Mallat, A.2    Rosenbaum, J.3    Zafrani, E.-S.4    Mauvier, P.5
  • 17
    • 0033119248 scopus 로고    scopus 로고
    • Pentoxifylline inhibits PDGF-induced proliferation and TGF-β-stimulated collagen synthesis by vascular smooth muscle cells
    • Chen Y.-M., Wu K.D., Tsai T.J., and Hseih B.S. Pentoxifylline inhibits PDGF-induced proliferation and TGF-β-stimulated collagen synthesis by vascular smooth muscle cells. J Mol Cell Cardiol 31 4 (1999) 773-783
    • (1999) J Mol Cell Cardiol , vol.31 , Issue.4 , pp. 773-783
    • Chen, Y.-M.1    Wu, K.D.2    Tsai, T.J.3    Hseih, B.S.4
  • 18
    • 0033983976 scopus 로고    scopus 로고
    • Pentoxifylline reduces in vitro renal myofibroblast proliferation and collagen secretion
    • Hewitson T.D., Martic M., Kelynack K.J., Pedagogos E., and Becker G.J. Pentoxifylline reduces in vitro renal myofibroblast proliferation and collagen secretion. Am J Nephrol 20 1 (2000) 82-88
    • (2000) Am J Nephrol , vol.20 , Issue.1 , pp. 82-88
    • Hewitson, T.D.1    Martic, M.2    Kelynack, K.J.3    Pedagogos, E.4    Becker, G.J.5
  • 19
    • 0036892615 scopus 로고    scopus 로고
    • Pentoxifylline attenuated the renal disease progression in rats with remnant kidney
    • Lin S.L., Chen Y.M., Chien C.T., Chien W.C., Tsai C.C., and Tsai T.J. Pentoxifylline attenuated the renal disease progression in rats with remnant kidney. J Am Soc Nephrol 13 12 (2002) 2916-2929
    • (2002) J Am Soc Nephrol , vol.13 , Issue.12 , pp. 2916-2929
    • Lin, S.L.1    Chen, Y.M.2    Chien, C.T.3    Chien, W.C.4    Tsai, C.C.5    Tsai, T.J.6
  • 20
    • 1542351289 scopus 로고    scopus 로고
    • L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures
    • Valente E.G.A., Vernet D., Ferrini M.G., Qian A., Rajfer J., and Gonzalez-Cadavid N.F. L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures. Nitric Oxide 9 4 (2003) 229-244
    • (2003) Nitric Oxide , vol.9 , Issue.4 , pp. 229-244
    • Valente, E.G.A.1    Vernet, D.2    Ferrini, M.G.3    Qian, A.4    Rajfer, J.5    Gonzalez-Cadavid, N.F.6
  • 21
    • 0026595995 scopus 로고
    • Fibroproliferation in liver disease: role of monocyte factors
    • Peterson T.C., and Isbrucker R.A. Fibroproliferation in liver disease: role of monocyte factors. Hepatology 15 (1992) 191-197
    • (1992) Hepatology , vol.15 , pp. 191-197
    • Peterson, T.C.1    Isbrucker, R.A.2
  • 22
    • 0027415060 scopus 로고
    • Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts
    • Peterson T.C. Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts. Hepatology 17 3 (1993) 486-493
    • (1993) Hepatology , vol.17 , Issue.3 , pp. 486-493
    • Peterson, T.C.1
  • 23
    • 0030007465 scopus 로고    scopus 로고
    • Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism
    • Peterson T.C., and Neumeister M. Effect of pentoxifylline in rat and swine models of hepatic fibrosis: role of fibroproliferation in its mechanism. Immunopharmacol 31 (1996) 183-193
    • (1996) Immunopharmacol , vol.31 , pp. 183-193
    • Peterson, T.C.1    Neumeister, M.2
  • 24
    • 0022595673 scopus 로고
    • Pharmacokinetics of orally administered pentoxifylline in humans
    • Smith R., Waller E., Doluisio J., Bauza M., Puri S., Ho I., et al. Pharmacokinetics of orally administered pentoxifylline in humans. J Pharm Sci 75 (1986) 47-52
    • (1986) J Pharm Sci , vol.75 , pp. 47-52
    • Smith, R.1    Waller, E.2    Doluisio, J.3    Bauza, M.4    Puri, S.5    Ho, I.6
  • 25
    • 0021253301 scopus 로고
    • Pharmacology of PTX: a hemorrheologic agent for the treatment of intermittent claudication
    • Aviado D., and Dettelbach H. Pharmacology of PTX: a hemorrheologic agent for the treatment of intermittent claudication. Angiol 35 (1984) 407-417
    • (1984) Angiol , vol.35 , pp. 407-417
    • Aviado, D.1    Dettelbach, H.2
  • 26
    • 0026470646 scopus 로고
    • Effect of ingested pentoxifylline on neutrophil superoxide production
    • Crouch S.P.M., and Fletcher J. Effect of ingested pentoxifylline on neutrophil superoxide production. Infect Immun 60 11 (1992) 4504-4509.
    • (1992) Infect Immun , vol.60 , Issue.11
    • Crouch, S.P.M.1    Fletcher, J.2
  • 27
    • 0029957888 scopus 로고    scopus 로고
    • Inhibition of fibroproliferation by pentoxifylline. Activity of metabolite-1 and lack of role of adenosine receptors
    • Peterson T.C. Inhibition of fibroproliferation by pentoxifylline. Activity of metabolite-1 and lack of role of adenosine receptors. Biochem Pharmacol 52 4 (1996) 597-602
    • (1996) Biochem Pharmacol , vol.52 , Issue.4 , pp. 597-602
    • Peterson, T.C.1
  • 28
    • 0009275827 scopus 로고
    • Effect of PDGF, PTX and M-1 on collagen synthesis in porcine hepatic stellate cells
    • Isbrucker R.A., and Peterson T.C. Effect of PDGF, PTX and M-1 on collagen synthesis in porcine hepatic stellate cells. Hepatology 22 (1995) 4
    • (1995) Hepatology , vol.22 , pp. 4
    • Isbrucker, R.A.1    Peterson, T.C.2
  • 29
    • 0028228294 scopus 로고
    • Phase 1b trial of pentoxifylline and ciprofloxacin in patients treated with interleukin-2 and lymphokine-activated killer cell therapy for metastatic renal carcinoma
    • Thompson J.A., Bianco J.A., Benyunes M.C., Neubauer M.A., Slattery J.T., et al. Phase 1b trial of pentoxifylline and ciprofloxacin in patients treated with interleukin-2 and lymphokine-activated killer cell therapy for metastatic renal carcinoma. Cancer Res 54 (1994) 3436-3441
    • (1994) Cancer Res , vol.54 , pp. 3436-3441
    • Thompson, J.A.1    Bianco, J.A.2    Benyunes, M.C.3    Neubauer, M.A.4    Slattery, J.T.5
  • 30
    • 24544443158 scopus 로고    scopus 로고
    • Investigation of the PTX/CIPRO drug interaction in the mouse
    • Wornell P.A., and Peterson T.C. Investigation of the PTX/CIPRO drug interaction in the mouse. Hepatology 26 (1997) 453A
    • (1997) Hepatology , vol.26
    • Wornell, P.A.1    Peterson, T.C.2
  • 31
    • 0028104858 scopus 로고
    • In vitro effect of platelet-derived growth factor on fibroproliferation and effect of cytokine antagonists
    • Peterson T.C., Isbrucker R., and Hooper M.L. In vitro effect of platelet-derived growth factor on fibroproliferation and effect of cytokine antagonists. Immunopharmacology 28 (1994) 259-270
    • (1994) Immunopharmacology , vol.28 , pp. 259-270
    • Peterson, T.C.1    Isbrucker, R.2    Hooper, M.L.3
  • 32
    • 34447256388 scopus 로고
    • Stereochemistry
    • Hamann K.P., Williams J., Wise K., Merill L., and Roll M. (Eds), D.C. Heath and Co., USA
    • Ege S. Stereochemistry. In: Hamann K.P., Williams J., Wise K., Merill L., and Roll M. (Eds). Organic Chemistry: structure and reactivity (1994), D.C. Heath and Co., USA 196-240
    • (1994) Organic Chemistry: structure and reactivity , pp. 196-240
    • Ege, S.1
  • 33
    • 0343463626 scopus 로고
    • Effect of PTX in a heterologous serum model of fibrosis
    • Hodgson P.D., and Peterson T.C. Effect of PTX in a heterologous serum model of fibrosis. Hepatology 22 (1995) 4
    • (1995) Hepatology , vol.22 , pp. 4
    • Hodgson, P.D.1    Peterson, T.C.2
  • 34
    • 24544436671 scopus 로고    scopus 로고
    • Increased level of antifibrotic drugs due to selective inhibition of CYP1A2
    • Blanchard M.G., and Peterson T.C. Increased level of antifibrotic drugs due to selective inhibition of CYP1A2. Hepatology 30 (1999) 558A
    • (1999) Hepatology , vol.30
    • Blanchard, M.G.1    Peterson, T.C.2
  • 35
    • 0036063383 scopus 로고    scopus 로고
    • Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans
    • Nicklasson M., Bjorkman S., Roth B., Jonsson M., and Hoglund P. Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans. Chirality 14 (2002) 643-652
    • (2002) Chirality , vol.14 , pp. 643-652
    • Nicklasson, M.1    Bjorkman, S.2    Roth, B.3    Jonsson, M.4    Hoglund, P.5
  • 36
    • 0030476589 scopus 로고    scopus 로고
    • Metabolism of lysofylline and pentoxifylline in human liver microsomes and cytosol
    • Lillibridge J.A., Kalhorn T.F., and Slattery J.T. Metabolism of lysofylline and pentoxifylline in human liver microsomes and cytosol. Drug Metab Dispos 24 11 (1996) 174-179
    • (1996) Drug Metab Dispos , vol.24 , Issue.11 , pp. 174-179
    • Lillibridge, J.A.1    Kalhorn, T.F.2    Slattery, J.T.3
  • 37
    • 0031435602 scopus 로고    scopus 로고
    • Cytochrome P450 isozymes involved in lisofylline metabolism to pentoxifylline in human liver mocrosomes
    • Lee S.H., and Slattery J.T. Cytochrome P450 isozymes involved in lisofylline metabolism to pentoxifylline in human liver mocrosomes. Drug Metab Dispos 25 12 (1997) 1354-1358
    • (1997) Drug Metab Dispos , vol.25 , Issue.12 , pp. 1354-1358
    • Lee, S.H.1    Slattery, J.T.2
  • 38
    • 0026718146 scopus 로고
    • Inhibitory potency of quinolone antibacterial agents against cytochrome P4501A2 activity in vivo and in vitro
    • Fuhr U., Anders E.M., Mahr G., Sorgel F., and Staib A.H. Inhibitory potency of quinolone antibacterial agents against cytochrome P4501A2 activity in vivo and in vitro. Antimicrob Agents Chemother 36 (1992) 942-948
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 942-948
    • Fuhr, U.1    Anders, E.M.2    Mahr, G.3    Sorgel, F.4    Staib, A.H.5
  • 39
    • 0034676738 scopus 로고    scopus 로고
    • Methadone, ciprofloxacin and adverse drug reactions
    • Herrlin K., Segerdahl M., Gustafsson L.L., and Kalso E. Methadone, ciprofloxacin and adverse drug reactions. Lancet 356 (2000) 2069-2070
    • (2000) Lancet , vol.356 , pp. 2069-2070
    • Herrlin, K.1    Segerdahl, M.2    Gustafsson, L.L.3    Kalso, E.4
  • 40
    • 0032096334 scopus 로고    scopus 로고
    • The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP
    • Peterson T.C., Slysz G., and Isbrucker R. The inhibitory effect of ursodeoxycholic acid and pentoxifylline on platelet derived growth factor-stimulated proliferation is distinct from an effect by cyclic AMP. Imunopharmacol 39 (1998) 181-191
    • (1998) Imunopharmacol , vol.39 , pp. 181-191
    • Peterson, T.C.1    Slysz, G.2    Isbrucker, R.3
  • 41
    • 0031947564 scopus 로고    scopus 로고
    • CYP3A4-mediated oxidation of lisofylline to lisofylline 4,5-diol in human liver microsomes
    • Shin H.S., and Slattery J.T. CYP3A4-mediated oxidation of lisofylline to lisofylline 4,5-diol in human liver microsomes. J Pharm Sci 87 3 (1998) 390-393
    • (1998) J Pharm Sci , vol.87 , Issue.3 , pp. 390-393
    • Shin, H.S.1    Slattery, J.T.2
  • 42
    • 0029858260 scopus 로고    scopus 로고
    • Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human
    • McLellan R.A., Drobitch R.K., Manshouwer M., and Renton K.W. Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human. Drug Metab Dispos 24 10 (1996) 1134-1138
    • (1996) Drug Metab Dispos , vol.24 , Issue.10 , pp. 1134-1138
    • McLellan, R.A.1    Drobitch, R.K.2    Manshouwer, M.3    Renton, K.W.4
  • 43
    • 2442453484 scopus 로고    scopus 로고
    • Therapeutic manipulation of the enteric microflora in inflammatory bowel disease: antibiotics, probiotics and prebiotics
    • Sartor R.B. Therapeutic manipulation of the enteric microflora in inflammatory bowel disease: antibiotics, probiotics and prebiotics. Gastroenterology 126 6 (2004) 1620-1633
    • (2004) Gastroenterology , vol.126 , Issue.6 , pp. 1620-1633
    • Sartor, R.B.1
  • 44


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.