Protein profiling: A possible molecular mechanism to mislocalization and down-expression of p27Kip1 in tumor cells

Medical Hypotheses

Volumn 69, Issue 3, 2007, Pages 580-583

  Guan, Xiaoxiang ^a   Chen, Longbang ^a   Wang, Jinghua ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN E; MESSENGER RNA; PROTEIN P15; PROTEIN P16; PROTEIN P18; PROTEIN P19; PROTEIN P53; PROTEIN SPY1; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CYTOPLASM; HUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; REGULATORY MECHANISM; TUMOR CELL;

CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYTOPLASM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; PROGNOSIS; RNA PROCESSING, POST-TRANSCRIPTIONAL;

EID: 34447271538     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.01.034     Document Type: Article

References (21)

1. Sherr C.J., and Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13 12 (1999) 1501-1512
2. Blain S.W., Scher H.I., Cordon-Cardo C., and Koff A. p27 as a target for cancer therapeutics. Cancer Cell 3 (2003) 111-115
3. Lloyd R.V., Erickson L.A., Jin L., Kulig E., Qian X., Cheville J.C., et al. p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers. Am J Pathol 154 2 (1999) 313-323
4. Barnes A., Pinder S.E., Bell J.A., Paish E.C., Wencyk P.M., Robertson J.F., et al. Expression of p27kip1 in breast cancer and its prognostic significance. J Pathol 201 3 (2003) 451-459
5. Filipits M., Pohl G., Stranzl T., Kaufmann H., Ackermann J., Gisslinger H., et al. Low p27Kip1 expression is an independent adverse prognostic factor in patients with multiple myeloma. Clin Cancer Res 9 2 (2003) 820-826
6. Chiarle R., Budel L.M., and Skolink J. Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. Blood 95 (2000) 619-626
7. Yang H.Y., Zhou B.P., Hung M.C., and Lee M.H. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. J Biol Chem 275 (2000) 24735-24739
8. Viglietto G., Motti M.L., and Fusco A. Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization. Cell Cycle 1 (2002) 394-400
9. Katner A.L., Hoang Q.B., Gootam P., Jaruga E., Ma Q., Gnarra J., et al. Induction of cell cycle arrest and apoptosis in human prostate carcinoma cells by a recombinant adenovirus expressing p27(Kip1). Prostate 53 (2002) 77-87
10. Shin I., Yakes F.M., Rojo F., Shin N.-Y., Bakin A.V., Baselga J., et al. Akt/PKB mediates cell cycle progression by phosphorylation of p27kip1 on threonine157 and modulation of its cellular localization. Nat Med 8 (2002) 1145-1152
11. Supriatno H.K., Hoque M.O., Bando T., Yoshida H., and Sato M. Overexpression of p27(Kip1) induces growth arrest and apoptosis in an oral cancer cell line. Oral Oncol 38 (2002) 730-736
12. Koh T.Y., Park S.W., Park K.H., Lee S.G., Seol J.-G., Lee D.W., et al. Inhibitory effect of p27KIP1 gene transfer on head and neck squamous cell carcinoma cell lines. Head Neck 25 1 (2003) 44-49
13. Ishida N., Hara T., Kamura T., Yoshida M., Nakayama K., and Nakayama K.I. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem 277 17 (2002) 14355-14358
14. Kawamata N., Morosetti R., Miller C.W., Park D., Spirin K.S., Nakamaki T., et al. Molecular analysis of the cyclin-dependent kinase inhibitor gene p27Kip1 in human malignancies. Cancer Res 55 (1995) 2266-2269
15. Vidal A., and Koff A. Cell-cycle inhibitors: three families united by a common cause. Gene 247 (2000) 1-15
16. Polyak K. The p27Kip1 tumor suppressor gene: still a suspect or proven guilty?. Cancer Cell (2006) 352-354
17. Rodier G., Montagnoli A., Marcotullio L.D., Coulombe P., Draetta G.F., Pagano M., et al. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J 20 (2001) 6672-6682
18. Guan X., Chen L., Wang J., Geng H., Chu X., Zhang Q., et al. Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line. Biochem Biophys Res Commun 347 3 (2006) 601-607
19. Blain S.W., and Massague J. Breast cancer banishes p27kip1 from nucleus. Nat Med 8 (2002) 1076-1078
20. Zhu Z., Jiang W., and Thompson H.J. Mechanisms by which energy restriction inhibits rat mammary carcinogenesis: in vivo effects of corticosterone on cell cycle machinery in mammary carcinomas. Carcinogenesis 24 7 (2003) 1225-1231
21. Porter L.A., Kong-Beltran M., and Donoghue D.J. Spy1 interacts with p27Kip1 to allow G1/S progression. Mol Biol Cell 14 9 (2003) 3664-3674