Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma

Veterinary Pathology

Volumn 44, Issue 4, 2007, Pages 467-478

  Fosmire, S P ^a,b   Thomas, R ^c   Jubala, C M ^a,b   Wojcieszyn, J W ^d   Valli, V E O ^e   Getzy, D M ^f   Smith, T L ^b   Gardner, L A ^a,b   Ritt, M G ^g   Bell, J S ^h   Freeman, K P ⁱ   Greenfield, B E ^j   Lana, S E ^k   Kisseberth, W C ^l   Helfand, S C ^m   Cutter, G R ⁿ   Breen, M ^c   Modiano, Jaime F ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d IHC Services   (United States)

^e UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^f IDEXX Veterinary Services Laboratory   (United States)

^g Animal Hospital Center   (United States)

^h TUFTS UNIVERSITY   (United States)

ⁱ Southfields Veterinary Specialists Part of Linnaeus Veterinary Limited   (United States)

^j Animal Clinic Northview   (United States)

^k Department of Environmental and Radiological Health Sciences   (United States)

^l OHIO STATE UNIVERSITY   (United States)

^m OREGON STATE UNIVERSITY   (United States)

ⁿ UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

more..

Author keywords

Canines; Cell cycle; Non Hodgkin's lymphoma; Tumor suppressor genes

Indexed keywords

PROTEIN P16INK4A; RETINOBLASTOMA PROTEIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; B CELL LYMPHOMA; DOG; DOG DISEASE; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; MALE; METABOLISM; T CELL LYMPHOMA;

ANIMALS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; LYMPHOMA, B-CELL; LYMPHOMA, T-CELL; MALE; RETINOBLASTOMA PROTEIN;

CANIS FAMILIARIS;

EID: 34447133586     PISSN: 03009858     EISSN: 15442217     Source Type: Journal    
DOI: 10.1354/vp.44-4-467     Document Type: Article

References (48)

1. Ausserlechner MJ, Obexer P, Geley S, Kofler R: G1 arrest by p16INK4A uncouples growth from cell cycle progression in leukemia cells with deregulated cyclin E and c-Myc expression. Leukemia 19:1051-1057, 2005
2. Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, Fisher DE, DeCaprio JA, Modiano JF, Burakoff SJ: NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell 10:1071-1081, 2002
3. Bouchard C, Thieke K, Maier A, Saffrich R, Hanley-Hyde J, Ansorge W, Reed S, Sicinski P, Bartek J, Eilers M: Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J 18:5321-5333, 1999
4. Cayuela JM, Gardie B, Sigaux F: Disruption of the multiple tumor suppressor gene MTS1/p16(INK4a)/CDKN2 by illegitimate V(D)J recombinase activity in T-cell acute lymphoblastic leukemias. Blood 90:3720-3726, 1997
5. Chitko-McKown CG, Modiano JF: Clues to immune function and oncogenesis provided by events that activate the cell cycle machinery in normal human T cells. J Leukoc Biol 62:430-437, 1997
6. Delmer A, Tang R, Senamaud-Beaufort C, Paterlini P, Brechot C, Zittoun R: Alterations of cyclin-dependent kinase 4 inhibitor (p16INK4A/MTS1) gene structure and expression in acute lymphoblastic leukemias. Leukemia 9:1240-1245, 1995
7. Dickerson EB, Fosmire S, Padilla ML, Modiano JF, Helfand SC: Potential to target dysregulated interleukin-2 receptor expression in canine lymphoid and hematopoietic malignancies as a model for human cancer. J Immunother 25:36-45, 2002
8. Drexler HG: Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia 12:845-859, 1998
9. Erickson S, Sangfelt O, Heyman M, Castro J, Einhorn S, Grander D: Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence. Oncogene 17:595-602, 1998
10. Escalon MP, Liu NS, Yang Y, Hess M, Walker PL, Smith TL, Dang NH: Prognostic factors and treatment of patients with T-cell non-Hodgkin lymphoma: the M. D. Anderson Cancer Center experience. Cancer 103:2091-2098, 2005
11. Evens AM, Gartenhaus RB: Molecular etiology of mature T-cell non-Hodgkin's lymphomas. Front Biosci 8:156-175, 2003
12. Fernandez-Piqueras J, Santos J, Perez de Castro I, Melendez B, Martinez B, Robledo M, Rivas C, Benitez J: Frequent allelic losses of 9p21 markers and low incidence of mutations at p16(CDKN2) gene in non-Hodgkin lymphomas of B-cell lineage. Cancer Genet Cytogenet 98:63-68, 1997
13. Geradts J, Andriko JW, Abbondanzo SL: Loss of tumor suppressor gene expression in high-grade but not low-grade non-Hodgkin's lymphomas. Am J Clin Pathol 109:669-674, 1998
14. Gronbaek K, de Nully Brown P, Moller MB, Nedergaard T, Ralfkiaer E, Moller P, Zeuthen J, Guldberg P: Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin's lymphoma. Leukemia 14:1727-1735, 2000
15. Hermeking H, Rago C, Schuhmacher M, Li Q, Barrett JF, Obaya AJ, O'Connell BC, Mateyak MK, Tam W, Kohlhuber F, Dang CV, Sedivy JM, Eick D, Vogelstein B, Kinzler KW: Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A 97:2229-2234, 2000
16. Husson H, Carideo EG, Neuberg D, Schultze J, Munoz O, Marks PW, Donovan JW, Chillemi AC, O'Connell P, Freedman AS: Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays. Blood 99:282-289, 2002
17. Jubala CM, Wojcieszyn JW, Valli VEO, Getzy DM, Fosmire SP, Coffey D, Bellgrau D, Modiano JF: CD20 expression in normal canine B cells and in canine non-Hodgkin's lymphoma. Vet Pathol 42:468-476, 2005
18. Koenig A, Bianco SR, Fosmire S, Wojcieszyn J, Modiano JF: Expression and significance of p53, Rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma. Vet Pathol 39:458-472, 2002
19. Lea NC, Orr SJ, Stoeber K, Williams GH, Lam EW, Ibrahim MA, Mufti GJ, Thomas NS: Commitment point during G0->G1 that controls entry into the cell cycle. Mol Cell Biol 23:2351-2361, 2003
20. Liu YW, Chang KJ, Liu YC: DNA methylation is not involved in growth regulation of gene expression of proliferating cell nuclear antigen. Exp Cell Res 208:479-484, 1993
21. Lowe SW, Sherr CJ: Tumor suppression by Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev 13:77-83, 2003
22. Mauch PM, Armitage JO, Coiffier B, Dalla-Favera R, Harris NL: Non-Hodgkin's Lymphomas. Lippincott Williams & Wilkins, Philadelphia, 2003
23. Melendez B, Cuadros M, Robledo M, Rivas C, Fernandez-Piqueras J, Martinez-Delgado B, Benitez J: Coincidental LOH regions in mouse and humans: evidence for novel tumor suppressor loci at 9q22-q34 in non-Hodgkin's lymphomas. Leuk Res 27:627-633, 2003
24. Migliaccio M, Raj K, Menzel O, Rufer N: Mechanisms that limit the in vitro proliferative potential of human CD8+ T lymphocytes. J Immunol 174:3335-3343, 2005
25. Modiano JF, Breen M, Burnett RC, Parker HG, Inusah S, Thomas R, Avery PR, Lindblad-Toh K, Ostrander EA, Cutter GC, Avery AC: Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk. Cancer Res 65:5654-5661, 2005
26. Modiano JF, Breen M, Valli VE, Wojcieszyn JW, Cutter GR: Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma. Leukemia 21:184-187, 2007
27. Modiano JF, Getzy DM, Akol KG, Van Winkle TJ, Cockerell GL: Retrovirus-like activity in an immunosuppressed dog: pathological and immunological findings. J Comp Path 112:165-183, 1995
28. Modiano JF, Mayor J, Ball C, Fuentes MK, Linthicum DS: Cdk4 expression and activity are required for cytokine responsiveness in T cells. J Immunol 165:6693-6702, 2000
29. Nakamura M, Sugita K, Inukai T, Goi K, Iijima K, Tezuka T, Kojika S, Shiraishi K, Miyamoto N, Karakida N, Kagami K, T OK, Mori T, Nakazawa S: p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation. Leukemia 13:884-890, 1999
30. Okuda T, Shurtleff SA, Valentine MB, Raimondi SC, Head DR, Behm F, Curcio-Brint AM, Liu Q, Pui CH, Sherr CJ, Beach D, Look AT, Downing JR: Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia. Blood 85:2321-2330, 1995
31. Pinyol M, Hernandez L, Cazorla M, Balbin M, Jares P, Fernandez PL, Montserrat E, Cardesa A, Lopez-Otin C, Campo E: Deletions and loss of expression of p16INK4a and p21Waf1 genes are associated with aggressive variants of mantle cell lymphomas. Blood 89:272-280, 1997
32. Priester WA, McKay FW: The occurrence of tumors in domestic animals. Natl Cancer Inst Monogr 54:1-210, 1980
33. Ritt MG, Mayor J, Wojcieszyn J, Smith R, Barton CL, Modiano JF: Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition. Cancer Lett 158:73-84, 2000
34. Sanchez-Beato M, Sanchez-Aguilera A, Piris MA: Cell cycle deregulation in B-cell lymphomas. Blood 101:1220-1235, 2003
35. Scheuring UJ, Sabzevari H, Theofilopoulos AN: Proliferative arrest and cell cycle regulation in CD8(+)CD28(-) versus CD8(+)CD28(+) T cells. Hum Immunol 63:1000-1009, 2002
36. Schmitt CA, McCurrach ME, de Stanchina E, Wallace-Brodeur RR, Lowe SW: INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev 13:2670-2677, 1999
37. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA: Role of the INK4a locus in tumor suppression and cell mortality. Cell 85:27-37, 1996
38. Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA: Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413:86-91, 2001
39. Sherr CJ: The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 60:3689-3695, 2000
40. Suzuki T, Kitao S, Matsushime H, Yoshida M: HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4. EMBO Journal 15:1607-1614, 1996
41. Swerdlow SH, Williams ME: From centrocytic to mantle cell lymphoma: a clinicopathologic and molecular review of 3 decades. Hum Pathol 33:7-20, 2002
42. Thomas R, Scott A, Langford CF, Fosmire SP, Jubala CM, Lorentzen TD, Hitte C, Karlsson EK, Kirkness E, Ostrander EA, Galibert F, Lindblad-Toh K, Modiano JF, Breen M: Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. Genome Res 15:1831-1837, 2005
43. Thomas R, Smith KC, Ostrander EA, Galibert F, Breen M: Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes. Br J Cancer 89:1530-1537, 2003
44. Valli VE, Jacobs RM, Parodi AL, Vernau W, Moore PF: Classification of Hematopoietic Tumors of Domestic Animals, Second Series ed. AFIP-American Registry of Pathology, Washington, DC, 2002
45. Valli VE, Vernau W, de Lorimier LP, Graham PS, Moore PF: Canine indolent nodular lymphoma. Vet Pathol 43:241-256, 2006
46. Villuendas R, Sanchez-Beato M, Martinez JC, Saez AI, Martinez-Delgado B, Garcia JF, Mateo MS, Sanchez-Verde L, Benitez J, Martinez P, Piris MA: Loss of p16/INK4A protein expression in non-Hodgkin's lymphomas is a frequent finding associated with tumor progression. Am J Pathol 153:887-897, 1998
47. Voevodin A, Samilchuk E, Schatzl H, Boeri E, Franchini G: Interspecies transmission of macaque simian T-cell leukemia/lymphoma virus type 1 in baboons resulted in an outbreak of malignant lymphoma. J Virol 70:1633-1639, 1996
48. Yamada Y, Hatta Y, Murata K, Sugawara K, Ikeda S, Mine M, Maeda T, Hirakata Y, Kamihira S, Tsukasaki K, Ogawa S, Hirai H, Koeffler HP, Tomonaga M: Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. J Clin Oncol 15:1778-1785, 1997