Electron microscopic radioautographic study on protein synthesis in mitochondria of binucleate hepatocytes of aging mice

TheScientificWorldJournal

Volumn 7, Issue SUPPL. 1, 2007, Pages 1008-1023

  Nagata, Tetsuji ^a,b  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Shinshu Institute of Alternative Medicine   (Japan)

Author keywords

Aging; Em radioautography; Mitochondria; Mouse binucleate hepatocytes; Protein syntheses

Indexed keywords

LEUCINE; TRITIUM;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINUCLEATE SPORE; CELL LABELING; CONTROLLED STUDY; ELECTRON MICROSCOPY; EMBRYO; EXPERIMENTAL ANIMAL; FEMALE; LIVER CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRACTICE GUIDELINE; PROTEIN SYNTHESIS;

AGING; ANIMALS; CELLS, CULTURED; HEPATOCYTES; HUMANS; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PROTEIN BIOSYNTHESIS;

ANIMALIA; MUS;

EID: 34447132390     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2007.140     Document Type: Article

References (84)

1. Nagata, T., Shibata, O., and Nawa, T. (1967a) Electron microscopic radioautographic studies of nucleic acid and protein syntheses in the liver and kidney cells of chickens and mice in tissue culture. Arch. Histol. Japon. 28, 540-541.
2. Nagata, T., Shibata, O., and Nawa, T. (1967b) Incorporation of tritiated thymidine into mitochondrial DNA of the liver and kidney cells of chickens and mice in tissue culture. Histochemie 10, 305-308
3. Nagata, T. (1972a) Electron microscopic dry-mounting autoradiography. Proceedings of the 4th International Congress of Histochemistry and Cytochemistry, Kyoto. pp. 43-44.
4. Nagata, T. (1972b) Radioautographic study on intramitochondrial nucleic acid synthesis: Its relationship to the cell cycle in cultivated cells. Proceedings of the 4th International Congress of Histochemistry and Cytochemistry, Kyoto. pp. 223-224.
5. Nagata, T. (1972c) Electron microscopic radioautography of intramitochondrial RNA synthesis of HeLa cells in culture. Histochemie 32, 163-170.
6. Nagata, T. (1972d) Quantitative electron microscope radioautography of intramitochondrial nucleic acid synthesis. Acta Histochem. Cytochem. 5, 201-203.
7. Nagata, T. (1974) Electron microscopic radioautography of intramitochondrial nucleic acid syntheses in mammalian cells in vitro. Proceedings of the 8th International Congress on Electron Microscopy, Canberra. Vol. 2. pp. 346-347.
8. Nagata, T., Yamada, Y., Iwadare, N., and Murata, F. (1975) Relationship of intramitochondrial nucleic acid synthesis to the nucleoli in cultivated cells as revealed by electron microscopic radioautography. Proceedings of the 10th International Congress of Anatomy, Tokyo. pp. 474-475.
9. Nagata, T., Iwadare, N., and Murata, F. (1976) Mitochondrial and nucleolar RNA synthesis as revealed by electron microscopic radioautography. Proceedings of the 5th International Congress of Histochemistry and Cytochemistry, Bucharest. pp. 242-243.
10. Nagata, T. (1984) Electron microscopic observation of target cells previously observed by phase-contrast microscopy: electron microscopic radioautography of laser beam irradiated cultured cells. J. Clin. Electron Microsc. 17, 589-590.
11. Nagata, T. and Murata, F. (1977) Electron microscopic dry-mounting radioautography for diffusible compounds by means of ultracryotomy. Histochemistry 54, 75-82.
12. Nagata, T., Iwadare, N., and Murata, F. (1977a) Electron microscopic radioautography of nucleic acid synthesis in cultured cells treated with several carcinogens. Acta Pharmacol. Toxicol. 41, 64-65.
13. Nagata, T., Murata, F., Yoshida, K., Ohno, S., and Iwadare, N. (1977b) Whole mount radioautography of cultured cells as observed by high voltage electron microscopy. Proceedings of the 5th International Conference on High Voltage Electron Microscopy, Kyoto. pp. 347-350.
14. Nagata, T., Ohno, S., and Murata, F. (1977c) Electron microscopic dry-mounting radioautography for soluble compounds. Acta Pharmacol. Toxicol. 41, 62-63.
15. Nagata, T., Ito, M., and Chen, S. (2000) Aging changes of DNA synthesis in the submandibular glands of mice as observed by light and electron microscopic radioautography. Ann. Microsc. 1, 13-22.
16. Nagata, T., Ohno, S., Kawahara, I., Yamabayashi, S., Fujii, Y., and Murata, F. (1979) Light and electron microscopic radioautography of nucleic acid synthesis in mitochondria and peroxisomes of rat hepatic cells during and after DEHP administration. Acta Histochem. Cytochem. 16, 610-611.
17. Nagata, T., Ohno, S., Yoshida, K., and Murata, F. (1982a) Nucleic acid synthesis in proliferating peroxisomes of rat liver as revealed by electron microscopical radioautography. Histochem. J. 14, 197-204.
18. Nagata, T., Fujii, Y., and Usuda, N. (1982b) Demonstration of extranuclear nucleic acid synthesis in mammalian cells under experimental conditions by electron microscopic radioautography. Proceedings of the 10th International Congress on Electron Microscopy, Hamburg. Vol. 2. pp. 305-306.
19. Ma, H. and Nagata, T. (1988a) Studies on DNA synthesis of aging mice by means of electron microscopic radioautography. J. Clin. Electron Microsc. 21, 335-343.
20. Ma, H. and Nagata, T. (1988b) Electron microscopic radioautographic study of DNA synthesis in the livers of aging mice. J. Clin .Electron Microsc. 21, 715-716.
21. Ma, H., Gao, F., Sun, L., Jin, C., and Nagata, T. (1994) Electron microscopic radioautographic study on the synthesis of DNA, RNA and protein in the livers of aging mice. Med. Electron Microsc. 27, 349-351.
22. Nagata, T. (1992) Radiolabeling of soluble and insoluble compounds as demonstrated by light and electron microscopy. In Recent Advances in Cellular and Molecular Biology. Vol. 6. Wegmann, R.J. and Wegmann, M.A., Eds, Peters Press, Leuven. pp. 9-21.
23. Nagata, T., Usuda, N., and Ma, H. (1986) Electron microscopic radioautography of nucleic acid synthesis in pancreatic acinar cells of prenatal and postnatal aging mice. Proceedings of the 11th International Congress on Electron Microscopy, Kyoto. Vol. 3. pp. 2281-2282.
24. Sun, L., Gao, F., Jin, C., and Nagata, T. (1997) DNA synthesis in the trachea of aging mice by light and electron microscopic radioautography. Acta Histochem. Cytochem. 30, 211-220.
25. Hanai, T. and Nagata, T. (1994) Electron microscopic radioautographic study on nucleic acid synthesis in perinatal mouse kidney tissue. Med. Electron Microsc. 27, 355-357.
26. Gao, F., Ma, H., Sun, L., Jin, C., and Nagata, T. (1994) Electron microscopic radioautographic study on the nucleic acid and protein synthesis in the aging mouse testis. Med. Electron Microsc. 27, 360-362.
27. Gao, F., Chen, S., Sun, L., Kang, W., Wang, Z., and Nagata, T. (1995) Radioautographic study of the macromolecular synthesis of Leydig cells in aging mouse testis. Cell. Mol. Biol. 41, 145-150.
28. Yamada, A.T. and Nagata, T. (1992) Light and electron microscopic radioautography of DNA synthesis in the endometria of pregnant ovariectomized mice during activation of implantation window. Cell. Mol. Biol. 38, 763-774.
29. Yamada, A.T. and Nagata, T. (1993) Light and electron microscopic radioautographic studies on the RNA synthesis of peri-implanting pregnant mouse uterus during activation of receptivity for blastocyst implantation. Cell. Mol. Biol. 39, 221-233.
30. Ito, M. and Nagata, T. (1996) Electron microscopic radioautographic study on DNA synthesis and the ultrastructure of the adrenal gland in aging mice. Med. Electron Microsc. 29, 145-152.
31. Liang, Y., Ito, M., and Nagata, T. (1999) Light and electron microscopic radioautographic studies on RNA synthesis in aging mouse adrenal gland. Acta Anat. Nippon 74, 291-300.
32. Cui, H., Gao, F., Ma, H., and Nagata, T. (1996) Study on DNA synthesis of cellular elements in the cerebella of aging mice by light and electron microscopic radioautography. Proceedings of the 4th China-Japan Joint Histochemistry and Cytochemistry Symposium. Chongqing Publishing House, Chongqing. pp. 111-112.
33. Gunarso, W. (1984) Radioautographic studies on the nucleic acid synthesis in the retina of chicken embryo II. Electron microscopic radioautography. Shinshu Med. J. 32, 241-248.
34. Gunarso, W., Gao, F., Cui, H., Ma, H., and Nagata, T. (1996) A light and electron microscopic radioautographic study on RNA synthesis in the retina of chick embryo. Acta Histochem. 98, 300-322.
35. Gunarso, W., Gao, F., and Nagata, T. (1997) Development and DNA synthesis in the retina of chick embryo observed by light and electron microscopic radioautography. Cell. Mol. Biol. 43, 189-201.
36. Kong, Y. and Nagata, T. (1994) Electron microscopic radioautographic study on nucleic acid synthesis of perinatal mouse retina. Med. Electron Microsc. 27, 366-368.
37. Cui, H., Gao, F., and Nagata, T. (2000) Light microscopic radioautographic study on protein synthesis in perinatal mice corneas. Acta Histochem. Cytochem. 33, 31-37.
38. Ma, H., Gao, F., Olea, M.T., and Nagata, T. (1991) Protein synthesis in the livers of aging mice studied by electron microscopic radioautography. Cell. Mol. Biol. 37, 607-615.
39. Ma, H. and Nagata, T. (2000) Collagen and protein synthesis in the livers of aging mice as studied by electron microscopic radioautography. Ann. Microsc. 1, 13-22.
40. Nagata, T. (1993) Quantitative light and electron microscopic radioautographic studies on macromolecular synthesis in several organs of prenatal and postnatal aging mice. Chin. J. Histochem. Cytochem. 2, 106-108.
41. Nagata, T. (1994) Radioautography in Medicine. Shinshu University Press, Matsumoto. 268 p.
42. Nagata, T. (1995) Light and electron microscopic radioautographic studies on macromolecular synthesis in digestive organs of aging mice. Cell. Mol. Biol. 41, 21-38.
43. Nagata, T. (1996) Techniques and application of electron microscopic radioautography. J. Electron Microsc. 45, 258-274.
44. Nagata, T. (1997) Techniques and application of microscopic radioautography. Histol. Histopathol. 12, 1091-1124.
45. Nagata, T. (1999) Aging changes of macromolecular synthesis in various organs as observed by microscopic radioautography after incorporation of radiolabeled precursors. Methods Find. Exp. Clin. Pharmacol. 21, 683-706.
46. Nagata, T. (2000) Light and electron microscopic radioautographic study on the protein synthesis in the pancreas of aging mouse. Bull. Nagano Women's Jr. Coll. 8, 1-26.
47. Nagata, T. (2001) Special cytochemistry in cell biology. Int. Rev. Cytol. 211, 33-151.
48. Nagata, T. (2002) Radioautographology general and special. Prog. Histochem. Cytochem. 37(2), 59-226.
49. Nagata, T. (2003) Light and electron microscopic radioautographic studies on macromolecular synthesis in amitotic hepatocytes of aging mice. Cell. Mol. Biol. 49, 591-611.
50. Nagata, T. and Ma, H. (2003a) Electron microscopic radioautographic study on the macromolecular synthesis in binucleate hepatocytes of aging mouse. Ann. Microsc. 3, 53-68.
51. 3H-leucine. Ann. Microsc. 3, 70-84.
52. Nagata, T. (2006) Electron microscopic radioautographic study on protein synthesis in hepatocyte mitochondria of developing mice. TheScientificWorldJOURNAL 6, 1583-1598.
53. Nagata, T. and Ma, H. (2004) Electron microscopic radioautographic study on protein synthesis in amitotic hepatocytes of the aging mouse. Med. Electron Microsc. 37, 62-69.
54. Rudhe, C., Clifton, R., Chew, O., Zemam, K., Richter, S., Lamppa, G., Whelan, J., and Glaser, E. (2004) Processing of the dual targeted precursor protein of glutathione reductase in mitochondria and chloroplasts. J. Mol. Biol. 22, 639-647.
55. Millar, A.H., Heazlewood, J.L., Kristensen, B.K., Braun, H.P., and Moller, I.M. (2005) The plant mitochondrial proteome. Trends Plant. Sci. 10, 36-43.
56. Goswami, C., Datta, S., Biswas, K., and Saha, N. (2004) Cell volume changes affect gluconeogenesis in the perfused liver of the catfish Clarias batrachus. J. Biosci. 29, 337-347.
57. Polak, U., Jankowska, A., and Warchol, J.B. (2004) Influence of cycloheximide on apoptosis in CHO cells, induced by ethane 1,2- dimethanesulphonate (EDS). Rocz. Akad. Med. Bialymst. 49(Suppl 1), 11-13.
58. Pilichos, C., Preza, A., Kounavis, I., Zafeiratou, S., and Kapatsoris, D. (2005) Fine structural alterations induced by cortisol administration in non-adrenalectomized/non-fasted rat hepatocytes. Int. Immunopharmacol. 5, 93-96.
59. Juang, H.H. (2004) Modulation of iron on mitochondrial aconitase expression in human prostatic carcinoma cells. Mol. Cell. Biochem. 265, 185-194.
60. Mahata, B., Bhattacharyya, S.N., Mukherjee, S., and Adhya, S. (2005) Correction of translational defects in patientderived mutant mitochondria by complex-mediated import of a cytoplasmic tRNA. J. Biol. Chem. 18, 5141-5144.
61. Maneiro, E., Lopez-Armada, M.J., de Andres, M.C., Carames, B., Martin, M.A., Bonilla, A., Del Hoyo, P., Galdo, F., Arenas, J., and Blanco, F.J. (2005) Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes. Ann. Rheum. Dis. 64, 388-395.
62. Nagata, T. (2005) Aging changes of the urogenital organs of rodents as revealed by cytochemistry and radioautography. Ann. Rev. Biomed. Sci. 7, 7-67.
63. Nagata, T. and Ma, H. (2003b) Electron microscopic radioautographic study on nucleic acid synthesis in amitotic hepatocytes of the aging mouse. Med. Electron Microsc. 36, 263-271.
64. Nagata, T. and Ma, H. (2004) Electron microscopic radioautographic study on mitochondrial DNA synthesis in hepatocytes of aging mouse. Histochemistry 28, 540-541.
65. Nagata, T. and Ma, H. (2005a) Electron microscopic radioautographic study on mitochondrial DNA synthesis in hepatocytes of aging mouse. Ann. Microsc. 5, 4-18.
66. Nagata, T. and Ma, H. (2005b) Electron microscopic radioautographic study on RNA synthesis in hepatocytes of aging mouse. Microsc. Res. Tech. 67, 55-64.
67. Nagata, T. (1969) Electron microscopic radioautography of intramitochondrial RNA synthesis of HeLa cells in culture. Acta Anat. Nippon 44, 126-127
68. Guttes, E. and Guttes, S. (1964) Thymidine incorporation by mitochondria in Physarum polycephalum. Science 145, 1057-1058.
69. Schuster, F.L. (1965) A deoxyribose nucleic acid component in mitochondria of Didymium nigirpes, a slime mold. Exp. Cell Res. 39, 329-345.
70. Stone, G.E. and Miller, O.L., Jr. (1965) A stable mitochondrial DNA in Tetrahymena puriformis. Exp. Zool. 159, 33-37.
71. Chévremont, M. (1963) Cytoplasmic deoxyribonucleic acids: their mitochondrial localization and synthesis in somatic cells under experimental conditions and during the normal cell cycle in relation to the preparation for mitosis. Cell Growth and Cell Division. Symposia of the International Society for Cell Biology. Vol. 2. Harris, R.J.C., Ed. Academic Press, New York. pp. 323-333.
72. Meyer, R.R. (1966) Cytochemical and electron microscopic studies of mitochondrial DNA in cultured chick fibroblasts grown at subnormal temperature. J. Cell Biol. 31, 151A-152A.
73. Caro, L.G. (1962) High resolution autoradiography II. The problem of resolution. J. Cell Biol. 15, 189-198.
74. Salpeter, M.M., Bachmann, L., and Salpeter, E.E. (1969) Resolution in electron microscope radioautography. J. Cell Biol. 44, 1-20.
75. Nadler, N.J. (1971) The interpretation of grain counts in electron microscope radioautography. J. Cell Biol. 49, 377-382.
76. Uchida, K. and Mizuhira, V. (1971) Electron microscope autoradiography with special reference to the problem of resolution. Arch. Histol. Jpn. 31, 291-320.
77. Murata, F., Yoshida, K., Ohno, S., and Nagata, T. (1979) Electron microscopic radioautography using a combination of phenidon developer and domestic emulsion. Acta Histochem. Cytochem. 12, 443-450.
78. Nagata, T. (1984) Electron microscopic observation of target cells previously observed by phase-contrast microscopy: electron microscopic radioautography of laser beam irradiated cultured cells. J. Clin. Electron Microsc. 17, 589-590.
79. Yamada, A.T. (1994) Timely and topologically defined protein synthesis in the peri-implanting mouse endometrium revealed by light and electron microscopic radioauatography. Cell. Mol. Biol. 39, 1-12.
80. Yamada, A.T. and Nagata, T. (1994) Ribonucleic acid and protein synthesis in the uterus of pregnant mouse during activation of implantation window. Med. Electron Microsc. 27, 363-365.
81. Korr, H., Phillipi, V., Helg, C., Schiefer, J., Graeber, M.B., and Kreutzberg, G.W. (1997) Unscheduled DNA synthesis and mitochondrial DNA synthetic rate following injuring of the facial nerve. Acta Neuropathol. 94, 557-566.
82. Korr, H., Kurz, C., Seidler, T.O., Sommer, D., and Schmitz, C. (1998) Mitochondrial DNA synthesis studied autoradiographically in various cell types in vivo. Braz. J. Med. Biol. Res. 31, 289-298.
83. Schmitz, C., Axmacher, B., Zunker, U., and Korr, H. (1999a) Age related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain. Acta Neuropathol. 97, 71-81.
84. Schmitz, C., Materne, S., and Korr, H. (1999b) Cell-type-specific differences in age-related changes of DNA repair in the mouse brain - molecular basis for a new approach to understand the selective neuronal vulnerability in Alzheimer's disease. J .Alzheimers Dis. 1, 387-407.