High radiosensitivity of germ cells in human male fetus

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 7, 2007, Pages 2632-2639

  Lambrot, Romain ^a   Coffigny, Hervé ^a   Pairault, Catherine ^a   Lécureuil, Charlotte ^a   Frydman, René ^b   Habert, René ^a   Rouiller Fabre, Virginie ^a,c  

^a Laboratory of Differentiation and Radiobiology of the Gonads   (France)

^b HÔPITAL ANTOINE BÉCLÈRE   (France)

^c INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; ENZYME; MESSENGER RNA; PIFITHRIN ALPHA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; PROTEIN PUMA; TESTOSTERONE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL REGENERATION; CELL STRESS; CELL TYPE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; FETOTOXICITY; FETUS; FETUS DEVELOPMENT; FIRST TRIMESTER PREGNANCY; GAMMA RADIATION; GENE EXPRESSION REGULATION; GENOTOXICITY; GERM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IONIZING RADIATION; MALE; MALE INFERTILITY; ORGAN CULTURE TECHNIQUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIATION INJURY; RADIATION RESPONSE; RADIATION STERILIZATION; RADIOSENSITIVITY; REPRODUCTIVE TOXICITY; SERTOLI CELL; STEROIDOGENESIS; TESTIS DEVELOPMENT; TESTIS FUNCTION; TESTOSTERONE RELEASE; UPREGULATION;

EID: 34447128198     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-2652     Document Type: Article

References (35)

1. Wartenberg H 1989 Differentiation and development of the testes. New York: Raven Press
2. Gondos B 1980 Development and differentiation of the testis and male reproductive tract. In: Steinberger A, Steinberger E, eds. Testicular development, structure, and function. New York: Raven Press; 3-20
3. Olaso R, Habert R 2000 Genetic and cellular analysis of male germ cell development. J Androl 21:497-511
4. Boulogne B, Habert R, Levacher C 2003 Regulation of the proliferation of cocultured gonocytes and Sertoli cells by retinoids, triiodothyronine, and intracellular signaling factors: differences between fetal and neonatal cells. Mol Reprod Dev 65:194-203
5. Habert R, Lejeune H, Saez JM 2001 Origin, differentiation and regulation of fetal and adult Leydig cells. Mol Cell Endocrinol 179:47-74
6. Huhtaniemi I, Pelliniemi L 1992 Fetal Leydig cells: cellular origin, morphology, life span, and special functional features. Proc Soc Exp Biol Med 201:125-140
7. Lambrot R, Coffigny H, Pairault C, Donnadieu AC, Frydman R, Habert R, Rouiller-Fabre V 2006 Use of organ culture to study the human fetal testis development: effect of retinoic acid. J Clin Endocrinol Metab 91:2696-2703
8. Sharpe RM, Irvine DS 2004 How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health? BMJ 328:447-451
9. Adami HO, Bergstrom R, Mohner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Ziegler H, Rahu M, Gurevicius R, Stengrevics A 1994 Testicular cancer in nine northern European countries. Int J Cancer 59:33-38
10. Sharpe RM 2003 The 'oestrogen hypothesis'- where do we stand now? Int J Androl 26:2-15
11. Delbes G, Levacher C, Habert R 2006 Estrogen effects on fetal and neonatal testicular development. Reproduction 132:527-538
12. Skakkebaek NE, Rajpert-De Meyts E, Main KM 2001 Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16:972-978
13. Skakkebaek NE, Jorgensen N 2005 Testicular dysgenesis and fertility. Andrologia 37:217-218
14. Beaumont HM 1960 Changes in the radiosensitivity of the testis during foetal development. Int J Radiat Biol 2:247-256
15. Moreno SG, Dutrillaux B, Coffigny H 2001 High sensitivity of rat foetal germ cells to low dose-rate irradiation. Int J Radiat Biol 77:529-538
16. Vergouwen R, Huiskamp R, Bas R, Roepers-Gajadien H, Davids J, de Rooij D 1995 Radiosensitivity of testicular cells in the fetal mouse. Radiat Res 141:66-73
17. Evtouchenko L, Studer L, Spenger C, Dreher E, Seiler RW 1996 A mathematical model for the estimation of human embryonic and fetal age. Cell Transplant 5:453-464
18. Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, Gudkov AV 1999 A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285:1733-1737
19. Gary RK, Jensen DA 2005 The p53 inhibitor pifithrin-α forms a sparingly soluble derivative via intramolecular cyclization under physiological conditions. Mol Pharm 2:462-474
20. Livera G, Delbes G, Pairault C, Rouiller-Fabre V, Habert R 2006 Organotypic culture, a powerful model for studying rat and mouse fetal testis development. Cell Tissue Res 324:507-521
21. Abercrombie M 1946 Estimation of nuclear population from microtome sections. Anat Rec 94:238-248
22. Schluter C, Duchrow M, Wohlenberg C, Becker MH, Key G, Flad HD, Gerdes J 1993 The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol 123:513-522
23. Olaso R, Pairault C, Boulogne B, Durand P, Habert R 1998 Transforming growth factor β1 and β2 reduce the number of gonocytes by increasing apoptosis. Endocrinology 139:733-740
24. Habert R, Devif I, Gangnerau MN, Lecerf L 1991 Ontogenesis of the in vitro response of rat testis to gonadotropin-releasing hormone. Mol Cell Endocrinol 82:199-206
25. United Nations Scientific Committee on the Effects of Atomic Radiation 2000 Sources and effects of ionizing radiation. New York: United Nations Publication
26. Moreno SG, Dutrillaux B, Coffigny H 2002 Study of the gonocyte cell cycle in irradiated TP53 knockout mouse foetuses and newborns. Int J Radiat Biol 78:703-709
27. Pawlik TM, Keyomarsi K 2004 Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 59:928-942
28. Bendsen E, Byskov AG, Laursen SB, Larsen HP, Andersen CY, Westergaard LG 2003 Number of germ cells and somatic cells in human fetal testes during the first weeks after sex differentiation. Hum Reprod 18:13-18
29. Ogilvy-Stuart AL, Shalet SM 1993 Effect of radiation on the human reproductive system. Environ Health Perspect 101(Suppl 2):109-116
30. Chipuk JE, Green DR 2006 Dissecting p53-dependent apoptosis. Cell Death Differ 13:994-1002
31. Fei P, El-Deiry WS 2003 P53 and radiation responses. Oncogene 22:5774-5783
32. Iliakis G, Wang Y, Guan J, Wang H 2003 DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22:5834-5847
33. Taylor WR, Stark GR 2001 Regulation of the G2/M transition by p53. Oncogene 20:1803-1815
34. Yu J, Zhang L 2005 The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 331:851-858
35. Komarova EA, Neznanov N, Komarov PG, Chernov MV, Wang K, Gudkov AV 2003 p53 inhibitor pifithrin α can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem 278:15465-15468