Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1

Oncogene

Volumn 26, Issue 31, 2007, Pages 4523-4530

  Roche, K C ^a,b   Rocha, S ^a   Bracken, C P ^a   Perkins, N D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

ARF; Checkpoint kinases; DNA damage; NF B; p53

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; CYCLIN D1; FORKHEAD TRANSCRIPTION FACTOR; HISTONE H2AX; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P14; PROTEIN P53; SMAD PROTEIN; TRANSCRIPTION FACTOR RELA;

ARTICLE; CANCER THERAPY; CARCINOGENESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; ULTRAVIOLET RADIATION;

CELL CYCLE PROTEINS; DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; OSTEOSARCOMA; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 34447115825     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210233     Document Type: Article

References (25)

1. Abraham RT. (2001). Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196.
2. Bartek J, Lukas J. (2003). Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3: 421-429.
3. Campbell KJ, Rocha S, Perkins ND. (2004). Active repression of antiapoptotic gene expression by ReIA(p65) NF-κB. Mol Cell 13: 853-865.
4. Chen CL, Edelstein LC, Gelinas C. (2000). The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol 20: 2687-2695.
5. Cortez D, Guntuku S, Qin J, Elledge SJ. (2001). ATR and ATRIP: Partners in checkpoint signaling. Science 294: 1713-1716.
6. Durocher D, Jackson SP. (2002). The FHA domain. FEBS Lett 513: 58-66.
7. Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP et al. (2000). The molecular basis of FHA domain: phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell 6: 1169-1182.
8. Foray N, Marot D, Gabriel A, Randrianarison V, Carr AM, Perricaudet M et al. (2003). A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J 22: 2860-2871.
9. Jowsey PA, Doherty AJ, Rouse J. (2004). Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem 279: 55562-55569.
10. Kim RH, Flanders KC, Reffey SB, Anderson LA, Duckett CS, Perkins ND et al. (2001). SNIP1 inhibits NF-κB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J Biol Chem 276: 46297-46304.
11. Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP et al. (2000). A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-β signal transduction. Genes Dev 14: 1605-1616.
12. Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D et al. (2002). Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell 9: 10 45-1054.
13. Liao H, Byeon IJ, Tsai MD. (1999). Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53. J Mol Biol 294: 1041-1049.
14. Lin WC, Lin FT, Nevins JR. (2001). Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 15: 1833-1844.
15. Lowndes NF, Toh GW. (2005). DNA repair: the importance of phosphorylating histone H2AX. Curr Biol 15: R99-R102.
16. Motoyama N, Naka K. (2004). DNA damage tumor suppressor genes and genomic instability. Curr Opin Gene Dev 14: 11-16.
17. Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W. (2002). Histone H2A variants H2AX and H2AZ. Curr Opin Gene Dev 12: 162-169.
18. Rocha S, Campbell KJ, Perkins ND. (2003a). p53- and Mdm2-independent repression of NF-κB transactivation by the ARF tumor suppressor. Mol Cell 12: 15-25.
19. Rocha S, Garrett MD, Campbell KJ, Schumm K, Perkins ND. (2005). Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J 24: 1157-1169.
20. Rocha S, Martin AM, Meek DW, Perkins ND. (2003b). p53 Represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-κB subunit with histone deacetylase 1. Mol Cell Biol 23: 4713-4727.
21. Roche KC, Wiechens N, Owen-Hughes T, Perkins ND. (2004). The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression. Oncogene 23: 8185-8195.
22. Stiff T, Reis C, Alderton GK, Woodbine L, O'Driscoll M, Jeggo PA. (2005). Nbs1 is required for ATR-dependent phosphorylation events. EMBO J 24: 199-208.
23. Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S et al (1998). The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 17: 5001-5014.
24. Syljuasen RG, Sorensen CS, Hansen LT, Fugger K, Lundin C, Johansson F et al. (2005). Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol 25: 3553-3562.
25. Wang Y, Qin J. (2003). MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci USA 100: 15387-15392.