Cyclic AMP-dependent protein kinase and Epac mediate cyclic AMP responses in pancreatic acini

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 292, Issue 5, 2007, Pages

  Chaudhuri, Anamika ^a   Husain, Sohail Z ^a   Kolodecik, Thomas R ^a   Grant, Wayne M ^a   Gorelick, Fred S ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GI Research Laboratory   (United States)

Author keywords

Actin; Chymotrypsin; Secretion; Trypsin; Zymogen

Indexed keywords

ACTIN; ANTIPORTER; BINDING PROTEIN; CARBACHOL; CERULETIDE; CHYMOTRYPSINOGEN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOSKELETON PROTEIN; ENZYME PRECURSOR; LIGAND; MUSCARINIC AGENT; PROTEIN KINASE; TRYPSINOGEN; 8 BROMO CYCLIC AMP; CARBAZOLE DERIVATIVE; EPAC PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INDOLE DERIVATIVE; KT 5720; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ACINAR CELL; AMYLASE RELEASE; ANIMAL CELL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; PANCREAS; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CARBACHOL; CARBAZOLES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ENZYME PRECURSORS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INDOLES; MALE; PANCREAS, EXOCRINE; PROTEIN KINASE INHIBITORS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34347397202     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00478.2005     Document Type: Article

References (25)

1. Bos JL. Epac: a new cAMP target and new avenues in cAMP research. Nat Rev Mol Cell Biol 4: 733-738, 2003.
2. Bos JL. Linking Rap to cell adhesion. Curr Opin Cell Biol 17: 123-128, 2005.
3. Burnham DB, Williams JA. Effects of high concentrations of secretagogues on the morphology and secretory activity of the pancreas: a role for microfilaments. Cell Tissue Res 222: 201-212, 1982.
4. Chaudhuri A, Kolodecik TR, Gorelick FS. Effects of increased intracellular cAMP on carbachol-stimulated zymogen activation, secretion, and injury in the pancreatic acinar cell. Am J Physiol Gastrointest Liver Physiol 288: G235-G243, 2005.
5. De Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396: 474-477, 1998.
6. Eliasson L, Ma X, Renstrom E, Barg S, Berggren PO, Galvanovskis J, Gromada J, Jing X, Lundquist I, Salehi A, Sewing S, Rorsman P. SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol 121: 181-197, 2003.
7. Fallon M, Gorelick F, Anderson J, Mennone A, Saluja A, Steer M. Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas. Gastroenterology 108: 1863-1872, 1995.
8. Husain SZ, Prasad P, Grant WM, Kolodecik TR, Nathanson MH, Gorelick FS. The ryanodine receptor mediates early zymogen activation in pancreatitis. Proc Natl Acad Sci USA 102: 14386-14391, 2005.
9. Jungermann J, Lerch MM, Weidenbach H, Lutz MP, Kruger B, Adler G. Disassembly of rat pancreatic acinar cell cytoskeleton during supramaximal secretagogue stimulation. Am J Physiol Gastrointest Liver Physiol 268: G328-G338, 1995.
10. 2+ release in mouse pancreatic beta cells. J Physiol 566: 173-188, 2005.
11. 2+ release and exocytosis in pancreatic beta-cells. J Biol Chem 278: 8279-8285, 2003.
12. Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM. A family of cAMP-binding proteins that directly activate Rap1. Science 282: 2275-2279, 1998.
13. Lu Z, Kolodecik TR, Karne S, Nyce M, Gorelick F. Effect of ligands that increase cAMP on caerulein-induced zymogen activation in pancreatic acini. Am J Physiol Gastrointest Liver Physiol 285: G822-G828, 2003.
14. O'Konski MS, Pandol SJ. Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell. J Clin Invest 86: 1649-1657, 1990.
15. Perides G, Sharma A, Gopal A, Tao X, Dwyer K, Ligon B, Steer ML. Secretin differentially sensitizes rat pancreatic acini to the effects of supramaximal stimulation with caerulein. Am J Physiol Gastrointest Liver Physiol 289: G713-G721, 2005.
16. Renstrom E, Eliasson L, Rorsman P. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol 502: 105-118, 1997.
17. B receptor activation at a glutamatergic synapse. Nature 424: 775-778, 2003.
18. Saluja AK, Donovan EA, Yamanaka K, Yamaguchi Y, Hofbauer B, Steer ML. Cerulein-induced in vivo activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B. Gastroenterology 113: 304-311, 1997.
19. Schmid S, Modlin IM, Stoch A, Tang L, Rhee S, Nathanson M, Scheele GA, Gorelick FS. Telenzepine-sensitive muscarinic receptors on the rat pancreatic acinar cell. Am J Physiol Gastrointest Liver Physiol 274: G734-G741, 1998.
20. Seino S, Shibasaki T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol Rev 85: 1303-1342, 2005.
21. 2+ channel in insulin granule exocytosis. J Biol Chem 279: 7956-7961, 2004.
22. Singh VP, Saluja AK, Bhagat L, Hietaranta AJ, Song A, Mykoniatis A, Van Acker GJ, Steer ML. Serine protease inhibitor causes F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini. Gastroenterology 120: 1818-1827, 2001.
23. Waterford SD, Kolodecik TR, Thrower EC, Gorelick FS. Vacuolar ATPase regulates zymogen activation in pancreatic acini. J Biol Chem 280: 5430-5434, 2005.
24. Williams JA. Intracellular signaling mechanisms activated by cholecystokinin-regulating synthesis and secretion of digestive enzymes in pancreatic acinar cells. Annu Rev Physiol 63: 77-97, 2001.
25. Zwartkruis FJ, Wolthuis RM, Nabben NM, Franke B, Bos JL. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling. EMBO J 17: 5905-5912, 1998.