Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factor

Journal of General Virology

Volumn 88, Issue 7, 2007, Pages 1922-1927

  Fleming, Stephen B ^a   Anderson, Ian E ^b   Thomson, Jackie ^b   Deane, David L ^b   McInnes, Colin J ^b   McCaughan, Catherine A ^a   Mercer, Andrew A ^a   Haig, David M ^b  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b MOREDUN RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; VIRULENCE FACTOR; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE INSERTION; GENE LOCUS; IMMUNOMODULATION; MALE; NONHUMAN; PATHOGENESIS; POXVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEEP DISEASE; SKIN DISEASE; VIRUS RECOMBINANT; VIRUS VIRULENCE; WILD TYPE;

ANIMALS; CELLS, CULTURED; ECTHYMA, CONTAGIOUS; GENE DELETION; GENES, VIRAL; INTERLEUKIN-10; ORF VIRUS; RECOMBINATION, GENETIC; SHEEP; VIRAL PROTEINS; VIRULENCE;

ANIMALIA; ORF VIRUS; OVIS ARIES; PARAPOXVIRUS;

EID: 34347384261     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.82833-0     Document Type: Article

References (26)

1. Anderson, I. E., Reid, H. W., Nettleton, P. F., McInnes, C. J. & Haig, D. M. (2001). Detection of cellular cytokine mRNA expression during orf virus infection in sheep: differential IFN-γ mRNA expression by cells in primary versus reinfection skin lesions. Vet Immunol Immunopathol 83, 161-176.
2. Chan, A., Baird, M., Mercer, A. A. & Fleming, S. B. (2006). Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10. J Gen Virol 87, 3177-3181.
3. Chang, W. L., Baumgarth, N., Yu, D. & Barry, P. A. (2004). Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality. J Virol 78, 8720-8731.
4. Delhon, G., Tulman, E. R., Afonso, C. L., Lu, Z., de la Concha-Bermijillo, A., Lehmkuhl, H. D., Piccone, M. E., Kutish, G. F. & Rock, D. L. (2004). Genomes of the parapoxviruses orf virus and bovine papular stomatitis virus. J Virol 78, 168-177.
5. Fleming, S. B. & Mercer, A. A. (2006). Genus Parapoxvirus. In Pox-viruses, pp. 127-165. Edited by A. A. Mercer, A. Schmidt & O. Weber. In the series Birkhaeuser Advances in Infectious Diseases, series editors A. Schmidt, M. Wolff & S. Kaufmann. Basel: Birkhaeuser Verlag. (in press)
6. Fleming, S. B., Blok, J., Fraser, K. M., Mercer, A. A. & Robinson, A. J. (1993). Conservation of gene structure and arrangement between vaccinia virus and off virus. Virology 195, 175-184.
7. Fleming, S. B., McCaughan, C. A., Andrews, A. E., Nash, A. D. & Mercer, A. A. (1997). A homolog of interleukin-10 is encoded by the poxvirus off virus. J Virol 71, 4857-4861.
8. Fleming, S. B., Haig, D. M., Nettleton, P., Reid, H. W., McCaughan, C. A., Wise, L. M. & Mercer, A. A. (2000). Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus orf virus. Virus Genes 21, 85-95.
9. Haig, D. M. & McInnes, C. J. (2002). Immunity and counter-immunity during orf virus infection in sheep, Virus Res 88, 3-16.
10. Haig, D. M. & Mercer, A. A. (1998). Orf. Vet Res 29, 311-321.
11. Haig, D. M., Entrican, G., Yirrell, D., Deane, D. L., Millar, H. R. P., Norval, M. & Reid, H. W. (1992). Differential appearance of interferon gamma and colony stimulating activity in afferent versus efferent lymph following orf virus infection in sheep. Vet Dermatol 3, 221-229.
12. Haig, D. M., Deane, D. L., Percival, A., Myatt, N., Thomson, J., Inglis, L., Rothel, J., Seow, H.-F., Wood, P. & Miller, H. R. P. (1996a). The cytokine response of afferent lymph following orf virus reinfection of sheep. Vet Dermatol 7, 11-22.
13. Haig, D. M., Deane, D. L., Myatt, N., Thomson, J., Entrican, G., Rothel, J. & Reid, H. W. (1996b). The activation status of ovine CD45R+ and CD45R-efferent lymph T cells after off virus reinfection. J Comp Pathol 115, 163-174.
14. + T cells during orf virus reinfection. J Gen Virol 77, 953-961.
15. Haig, D. M., McInnes, C. J., Hutchison, G., Seow, H.-F. & Reid, H. W. (1996d). Cyclosporin-A abrogates the acquired immunity to cutaneous reinfection with the parapoxvirus orf virus. Immunology 89, 524-531.
16. Haig, D. M., Thomson, J., McInnes, C. J., Deane, D. L., Anderson, I., McCaughan, C. A., Imlach, W., Mercer, A. A., Howard, C. J. & Fleming, S. B. (2002). A comparison of the anti-inflammatory and immunostimulatory activities of orf virus and ovine interleukin-10. Virus Res 90, 303-316.
17. Imlach, W., Macaughan, C. A., Mercer, A. A., Haig, D. M. & Fleming, S. B. (2002). Orf virus-encoded interleukin 10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophages. J Gen Virol 83, 1049-1058.
18. Lateef, Z., Fleming, S. B., Halliday, G., Faulkner, L., Mercer, A. A. & Baird, M. (2003). Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells. J Gen Virol 84, 1101-1109.
19. Mackett, M., Smith, G. L. & Moss, B. (1984). General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes. J Virol 49, 857-864.
20. Mercer, A. A., Ueda, N., Friederichs, S.-M., Hofmann, K., Fraser, K., Bateman, T. & Fleming, S. B. (2006). Comparative analysis of genome sequences of three isolates of orf virus reveals unexpected sequence variation. Virus Res 116, 146-158.
21. Moore, K. W., de Waal Malefyte, R., Coffman, R. & O'Garra, A. (2001). Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19, 683-702.
22. Nettleton, P. F., Brebner, J., Pow, I., Gilray, J. A., Bell, G. D. & Reid, H. W. (1996). Tissue culture-propagated orf virus vaccine protects lambs from orf virus challenge. Vet Rec 138, 184-186.
23. Robinson, A. J., Barns, G., Fraser, K., Carpenter, E. & Mercer, A. A. (1987). Conservation and variation in orf virus genomes. Virology 157, 13-23.
24. Savory, L. J., Stacker, S. A., Fleming, S. B., Niven, B. E. & Mercer, A. A. (2000). Viral vascular endothelial growth factor plays a critical role in orf virus infection. J Virol 74, 10699-10706.
25. Vieira, P., de Waal-Malefyt, R., Dang, M., Johnson, K. E., Kastelein, R., Fiorentino, D. F., de Vries, J. E, Roncarolo, M.-G., Mosmann, T. R. & Moore, K. W. (1991). Isolation and expression of human cytokine synthesis inhibitory factor (CSIF/IL-10) cDNA clones: homology to Epstein-Barr virus open reading frame BCRF1. Proc Natl Acad Sci U S A 88, 1172-1176.
26. Wood, A. R. & McInnes, C. J. (2003). Transcript mapping of the early genes of orf virus. J Gen Virol 84, 2993-2998.