Cytolytic activity and associated serine protease expression by skin and afferent lymph CD8+ T cells during orf virus reinfection

Journal of General Virology

Volumn 77, Issue 5, 1996, Pages 953-961

  Haig, D McK ^a   Hutchison, G ^a   Thomson, J ^a   Yirrell, D ^b   Reid, H W ^a  

^a MOREDUN RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CELL MARKER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SERINE PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; FEMALE; HUMAN; POXVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REINFECTION; SHEEP; SKIN; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION; VIRUS REPLICATION;

EID: 0029930262     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-77-5-953     Document Type: Article

References (44)

1. ALCAMI, A. & SMITH, G. (1995). Cytokine receptors encoded by poxviruses: a lesson in cytokine biology. Immunology Today 16, 474-478.
2. BLACKLAWS, B. A., BIRD, P., ALLEN, D. & MCCONNELL, I. (1994). Circulating cytotoxic T lymphocyte precursors in maedi-visna virus-infected sheep. Journal of General Virology 75, 1589-1596.
3. GARCIA-SANZ, J. A., PLAETINCK, G., VELOTTI, F., MASSON, D., TSCHOPP, J., MACDONALD H. R. & NABHOLZ, M. (1987). Perforin is present only in normal activated Lyt2 + T lymphocytes and not in L3T4 + cells, but the serine protease granzyme-A is made by both subsets. EMBO Journal 6, 933-938.
4. GERSHENFELD, H. K., HERSHBERGER, R. J., SHOWS, T. B. & WEISSMAN, I. L. (1988). Cloning and chromosomal assignment of a human cDNA encoding a T cell and natural killer cell-specific trypsin-like serine protease. Proceedings of the National Academy of Sciences, USA 85, 1184-1188.
5. GRIFFITHS, G. M. & MUELLER, C. (1991). Expression of perform and granzymes in vivo: potential diagnostic markers for activated cytotoxic cells. Immunology Today 12, 415-419.
6. HAIG, D. M., WINDON, R., BLACKIE, W., BROWN, D. & SMITH, W. D. (1989). Parasite-specific T-cell responses of sheep following live infection with the gastric nematode Haemonchus contortus. Parasite Immunology 11, 463-477.
7. HAIG, D. M., ENTRICAN, G., YIRRELL, D. L., DEANE, D., MILLER, H. R. P., NORVAL, M. & REID, H. W. (1992). Differential appearance of interferon-γ and colony-stimulating activity in afferent versus efferent lymph following orf virus infection of sheep. Veterinary Dermatology 3, 221-229.
8. HAIG, D. M., DEANE, D., PERCIVAL, A., MYATT, N., THOMSON, J., INGLIS, L., ROTHEL, J., SEOW, H-F., WOOD, P., MILLER, H. R. P. & REID, H. W. (1996a). The local in vivo cytokine response of afferent lymph following orf virus reinfection of sheep. Veterinary Dermatology, in press.
9. HAIG, D. M , MCINESS, C. J., DEANE, D., REID, H. W. & MERCER, A. (1996b). The immune and inflammatory response to orf virus. Comparative Immunology and Microbiology of Infectious Disease 19, in press.
10. HUNTLEY, J. F., GIBSON, S., KNOX, D. & MILLER, H. R. P. (1986). The isolation and purification of a proteinase with chymotrypsin-like properties from ovine mucosal mast cells. International Journal of Biochemistry 18, 673-682.
11. ISSEKUTZ, T. B. (1985). Characteristics of lymphoblasts appearing in efferent lymph in response to immunisation with vaccinia virus. Immunology 56, 23-31.
12. JENKINSON, D. M., MCEWAN, P. E., ONWUKA, S. K., Moss, V. A., ELDER, H. Y., HUTCHISON, G. & REID, H. W. (1990). The polymorphonuclear and mast cell responses in ovine skin infected with orf virus. Veterinary Dermatology 1, 71-77.
13. JENKINSON, D. M., HUTCHISON, G., ONWUKA, S. K. & REID, H W (1991). Changes in the MHC class II dendritic cell population of ovine skin in response to orf virus infection. Veterinary Dermatology 2, 1-9.
14. JENKINSON, D M., HUTCHISON, G. & REID, H. W. (1992). The B and T cell responses to orf virus infection of ovine skin. Veterinary Dermatology 3, 57-64.
15. KAGI, D., VIGNAUX, F., LEDERMANN, B., BURKI, K., DEPRAETERE, V., NAGATA, S., HENGARTER, H. & GOLSTEIN, P. (1994). Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265, 528-530.
16. KOIZUMI, H., LIU, C-C., ZHENG, L. M., JOAG, S. J., BAYNE, N. K., HOLOSHITZ, J. & YOUNG, J. (1991). Expression of perform and serine esterases by human γ/δ T cells. Journal of Experimental Medicine 173, 499-502.
17. KRAMER, M D., FRUTH, U., SIMON, H.-G. & SIMON, M. (1989). Expression of cytoplasmic granules with T cell-associated serine proteinase-1 activity in Ly-2 (CD8) T lymphocytes responding to lymphocytic choriomeningitis virus in vivo. European Journal of Immunology 19, 151-156.
18. LEAR, A (1994). The cutaneous response of sheep to orf virus infection. PhD Thesis. University of Edinburgh.
19. LEAR, A., HUTCHISON, G., REID, H. W., NORVAL, M. & HAIG, D. M. (1996). Phenotypic characterisation of the dendritic cells accumulating in the ovine dermis following primary and secondary orf virus infections. European Journal of Dermatology 7, in press.
20. LIU, C.-C, RAFII, S., GRANELLI-PIPERINO, A., TRAPANI, J. A. & YOUNG, J. (1989) Perform and serine esterase gene expression in stimulated human T cells. Journal of Experimental Medicine 170, 2105-2118.
21. LIU, C.-C., WALSH, C. M. & YOUNG, J. (1995). Perform: structure and function. Immunology Today 16, 194-202.
22. LOWIN, B., HAHNE, M., MATTMANN. C. & TSCHOPP, J. (1994). Cytolytic T-cell cytotoxicity is mediated through perform and Fas lytic pathways. Nature 370, 650-652.
23. LYTTLE, D. J., FRASER, K. M., FLEMING, S. B., MERCER, A. A. & ROBINSON, A. J. (1994). Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. Journal of Virology 68, 84-92.
24. MACKAY, C. R., HEIN, W., BROWN, M. H. & MATZINGER, P. (1988). Unusual expression of CD-2 in sheep: implications for T-cell interactions. European Journal of Immunology 18, 1681-1688.
25. MACKAY, C. R , MARSTON, W. L. & DUDLER, L. (1990). Naive and memory T-cells show distinct pathways of lymphocyte recirculation. Journal of Experimental Medicine 171, 801-817.
26. MCKEEVER, D. J., JENKINSON, D. M., HUTCHISON, G. & REID, H. W. (1988). Studies on the pathogenesis of orf virus infection in sheep. Journal of Comparative Pathology 99, 317-328.
27. MADDOX, J. F., MACKAY, C. R. & BRANDON, M. R. (1985). Surface antigens SBU-T4 and SBU-T8 of sheep T lymphocyte subsets denned by monoclonal antibodies. Immunology 55, 739-748.
28. MORRISON, W. I. & DAVIS, W. C. (1991). Differentiation antigens expressed predominantly on CD4-, CD8- T lymphocytes (Wc1, Wc2). Veterinary Immunology and Immunopathology 27, 71-76.
29. NAKAJIMA, H., PARK, H. & HENKART, P. A. (1995). Synergistic roles of granzymes A and B in mediating target cell death by RBL mast cell tumors also expressing cytolysin/perforin. Journal of Experimental Medicine 181, 1037-1046.
30. NIXON, D. F. (1992). The cytotoxic T cell response to HIV. In Immunology of HIV Infection, pp. 59-73. Edited by A. G. Bird. Dordrecht: Kluwer Academic.
31. PASTERNACK, M. S. & EISEN, H. N. (1985). A novel serine esterase expressed by cytotoxic T lymphocytes. Nature 314, 743-745.
32. PICKUP, D. J. (1994). Poxviral modifiers of the cytokine response to infection. Infectious Agents and Disease 3, 116-127.
33. PURI, N. K., GOGOLIN-EWANS, K. J. & BRANDON, M. R. (1987). Monoclonal antibodies to sheep MHC class 1 and II molecules: biochemical characterisation of three class I gene products and four distinct sub-populations of class II molecules. Veterinary Immunology and Immunopathology 15, 59-86.
34. ROBINSON, A. J. & BALASSU, T. C. (1981). Contagious pustular dermatitis (orf). Veterinary Bulletin 51, 771.
35. SHI, L., KAM, C , POWERS J C , AEBERSOLD, R. & GREENBERG, A. H. (1992). Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. Journal of Experimental Medicine 176, 1521-1529.
36. SHIVER, J. W., SU, L. & HENKART, P. A. (1992). Cytotoxicity with target DNA breakdown by rat basophilic leukaemia cells expressing both cytolysin and granzyme-A. Cell 71, 315-322.
37. SMYTH, M. J. & TRAPANI, J. A. (1995). Granzymes: exogenous proteinases that induce target cell apoptosis Immunology Today 16, 202-206.
38. 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proceedings of the National Academy of Sciences, USA 89, 6070-6074.
39. TAKAYAMA, H., TRENN, G , HUMPHREY, W., BLUESTONE, J. A., HENKART, P. A. & SITKOVSKY, M. V. (1987). Antigen receptor-triggered secretion of a trypsin-type esterase from cytotoxic T lymphocytes. Journal of Immunology 138, 566-569.
40. TOWNSEND, A., BASTIN, J., GOULD, K., BROWNLEE, G., ANDREW, M., COUPER, B., BOYLE, D., CHAN, S. & SMITH, G. (1988). Defective presentation to class I-restricted cytotoxic T lymphocytes in vacciniainfected cells is overcome by enhanced degradation of antigen. Journal of Experimental Medicine 168, 1211-1224.
41. TRAPANI, J. A., SMYTH, M. J., APOSTOLIDIS, V. A., DAWSON, M. & BROWNE, K. A. (1994). Granule serine proteases are normal nuclear constituents of natural killer cells. Journal of Biological Chemistry 269, 18359-18365.
42. YIRRELL, D. L., REID, H. W., NORVAL, M. & HOWIE, S. E. M. (1989). Immune response of lambs to experimental infection with orf virus. Veterinary Immunology and Immunopathology 22, 321-332.
43. YIRRELL, D. L., REID. H. W., NORVAL, M., ENTRICAN, G. & MILLER, H. R. P. (1991 a). Response of efferent lymph and popliteal lymph node to epidermal infection of sheep with orf virus. Veterinary Immunology and Immunopathology 28, 219-235.
44. YIRRELL, D. L., REID, H. W., NORVAL, M. & MILLER, H. R. P. (1991b). Qualitative and quantitative changes in ovine afferent lymph draining the site of epidermal orf virus infection. Veterinary Dermatology 2, 133-141.