Detection of cellular cytokine mRNA expression during orf virus infection in sheep: Differential interferon-γ mRNA expression by cells in primary versus reinfection skin lesions

Veterinary Immunology and Immunopathology

Volumn 83, Issue 3-4, 2001, Pages 161-176

  Anderson, Ian E ^a   Reid, Hugh W ^a   Nettleton, Peter F ^a   McInnes, Colin J ^a   Haig, David M ^a  

^a MOREDUN RESEARCH INSTITUTE   (United Kingdom)

Author keywords

IFN ; IL 4; Immunity; In situ hybridization; Orf virus; Parapoxvirus; Skin; TNF

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BIOACCUMULATION; CELL TYPE; CONTROLLED STUDY; DENDRITIC CELL; DISEASE SEVERITY; EPIDERMIS CELL; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NEUTROPHIL; NONHUMAN; PARAPOXVIRUS; PRIMARY INFECTION; PROTEIN EXPRESSION; REINFECTION; SHEEP; SKIN BIOPSY; SKIN DEFECT; T LYMPHOCYTE; VASCULAR ENDOTHELIUM; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; BIOPSY; CYTOKINES; ECTHYMA, CONTAGIOUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERFERON TYPE II; ORF VIRUS; RNA PROBES; RNA, MESSENGER; SHEEP; SKIN DISEASES, VIRAL;

ORF VIRUS; OVIS ARIES; PARAPOXVIRUS;

EID: 0035197107     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(01)00388-9     Document Type: Article

References (37)

1. Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2
2. Intestinal nematode parasites, cytokines and effector mechanisms
3. Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2
4. A homolog of interleukin-10 is encoded by the poxvirus orf virus
5. Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus orf virus
6. Detection of immune system cells in paraffin wax-embedded ovine tissues
7. The survival and growth of ovine afferent lymph dendritic cells in culture depends on tumour necrosis factor-α and is enhanced by granulocyte-macrophage colony-stimulating factor but inhibited by interferon-γ
8. Immunomodulation by virulence proteins of the parapoxvirus orf virus
9. Differential appearance of interferon and colony stimulating activity in afferent versus efferent lymph following orf virus infection in sheep
10. The effect of intradermal injection of GM-CSF and TNF-α on the accumulation of dendritic cells in ovine skin
11. The cytokine response of afferent lymph following orf virus reinfection of sheep
12. - efferent lymph T cells after orf virus reinfection
13. + T cells during orf virus reinfection
14. Cyclosporin A abrogates the acquired immunity to cutaneous reinfection with the parapoxvirus orf virus
15. The orf virus OV20.0L gene product is involved in interferon resistance and inhibits an interferon-inducible, double-stranded RNA-dependent kinase
16. The reactivity of monoclonal antibodies against orf virus with other parapoxviruses and the identification of a 39 kDa immunodominant protein
17. In vivo depletion of BoT4 (CD4) and of non-T4/T8 lymphocyte subsets in cattle with monoclonal antibodies
18. Location and spread of orf virus antigen in infected ovine skin
19. The pathological changes and polymorphonuclear and mast cell responses in the skin of specific pathogen-free lambs following primary and secondary challenge with orf virus
20. + dendritic cell population of ovine skin in response to orf virus infection
21. The B and T cell responses to orf virus infection of ovine skin
22. Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets
23. Phenotypic characterization of the dendritic cells accumulating in ovine dermis following primary and secondary orf virus infections
24. In vivo T-cell subset depletion suggests that T-cells and a humoral immune response are important for the elimination of orf virus from the skin of sheep
25. Naïve and memory T cells show distinct pathways of lymphocyte recirculation
26. Surface antigens, SBU-T4 and SBU-T8, of sheep T lymphocyte subsets defined by monoclonal antibodies
27. The molecular cloning of the ovine gamma-interferon cDNA using the polymerase chain reaction
28. Orf virus encodes a homolog of the vaccinia virus interferon-resistance gene E3L
29. Survival of orf virus under British winter conditions
30. Studies of the pathogenesis of orf virus infection in sheep
31. Inflammatory cytokines in animal health and disease
32. Tissue culture-propagated orf virus vaccine protects lambs from orf virus challenge
33. Monoclonal antibodies to sheep MHC class I and class II molecules: Biochemical characterisation of three class I gene products and four distinct subpopulations of class II molecules
34. Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes
35. Cloning and sequencing an ovine interleukin-4-encoding cDNA
36. T cell cytokines and disease prevention