메뉴 건너뛰기




Volumn 3, Issue 3, 2007, Pages 299-306

Cancer vaccines: A promising cancer therapy against all odds

Author keywords

Active specific immunotherapy; Adjuvants; Carcinoembryonic antigen; Colorectal cancer; Dendritic cells; Immunotherapy; Melanoma; MUCI

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; ANTINEOPLASTIC AGENT; BCG VACCINE; CANCER VACCINE; CARCINOEMBRYONIC ANTIGEN; CYTOTOXIC AGENT; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DENDRITIC CELL VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MELANOMA VACCINE; MUCIN 1; PLACEBO; PROSTATE SPECIFIC ANTIGEN; PROVENGE; TROVAX; TUMOR CELL VACCINE; UNCLASSIFIED DRUG;

EID: 34347381738     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/14796694.3.3.299     Document Type: Review
Times cited : (16)

References (50)
  • 1
    • 16844368698 scopus 로고    scopus 로고
    • Tumor stem cells and drug resistance
    • Dean M, Fojo T, Bates S: Tumor stem cells and drug resistance. Nat. Rev. Cancer 5, 275-284 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 2
    • 33751016673 scopus 로고    scopus 로고
    • Neoplastic stem cells: A novel therapeutic target in clinical oncology
    • Schulenburg A, Ulrich-Pur H, Thurnher D et al.: Neoplastic stem cells: a novel therapeutic target in clinical oncology. Cancer 107(10), 2515-2520 (2006).
    • (2006) Cancer , vol.107 , Issue.10 , pp. 2515-2520
    • Schulenburg, A.1    Ulrich-Pur, H.2    Thurnher, D.3
  • 3
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, Costes A, Sanchez-Cabo F et al.: Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964 (2006).
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 4
    • 0037211750 scopus 로고    scopus 로고
    • Circulating anti-MUC 1 IgG antibodies as a favorable prognostic factor fbr pancreatic cancer
    • Hamanaka Y, Suehiro Y, Fukui M, Shikichi K, Imai K, Hinoda Y: Circulating anti-MUC 1 IgG antibodies as a favorable prognostic factor fbr pancreatic cancer. Int. J. Cancer 103, 97-100 (2003).
    • (2003) Int. J. Cancer , vol.103 , pp. 97-100
    • Hamanaka, Y.1    Suehiro, Y.2    Fukui, M.3    Shikichi, K.4    Imai, K.5    Hinoda, Y.6
  • 5
    • 17344392248 scopus 로고    scopus 로고
    • Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin
    • von Mensdorff-Pouilly S, Verstraeten AA, Kenemans P et al.: Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin. J. Clin. Oncol. 18, 574-583 (2000).
    • (2000) J. Clin. Oncol , vol.18 , pp. 574-583
    • von Mensdorff-Pouilly, S.1    Verstraeten, A.A.2    Kenemans, P.3
  • 6
    • 33847628325 scopus 로고    scopus 로고
    • Humoral immunity, inflammation and cancer
    • Tan TT, Coussens LM: Humoral immunity, inflammation and cancer. Curr. Opin. Immunol. 19, 1-8 (2007).
    • (2007) Curr. Opin. Immunol , vol.19 , pp. 1-8
    • Tan, T.T.1    Coussens, L.M.2
  • 7
    • 0037383526 scopus 로고    scopus 로고
    • Cancer immunotherapy: The past, the present and the future
    • Parish CR: Cancer immunotherapy: the past, the present and the future. Immunol. Cell Biol. 81, 106-113 (2003).
    • (2003) Immunol. Cell Biol , vol.81 , pp. 106-113
    • Parish, C.R.1
  • 8
    • 78651120598 scopus 로고
    • Demonstration of resistance against methylcholanthrene induced sarcomas in the primary autochthonous host
    • Klein G, Sjogren HO, Klein E, Hellstrom KE: Demonstration of resistance against methylcholanthrene induced sarcomas in the primary autochthonous host. Cancer Res. 20, 1561-1572 (1960).
    • (1960) Cancer Res , vol.20 , pp. 1561-1572
    • Klein, G.1    Sjogren, H.O.2    Klein, E.3    Hellstrom, K.E.4
  • 9
    • 0141720783 scopus 로고    scopus 로고
    • Cancer vaccines: Between the idea and the reality
    • Finn OJ: Cancer vaccines: between the idea and the reality. Nat. Rev. Immunol. 3, 630-641 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 630-641
    • Finn, O.J.1
  • 10
    • 9644303122 scopus 로고    scopus 로고
    • Colorectal cancer vaccines: Principles, results, and perspectives
    • Mocellin S, Rossi CR, Lise M, Nitti D: Colorectal cancer vaccines: principles, results, and perspectives. Gastroenterology 127, 1821-1837 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 1821-1837
    • Mocellin, S.1    Rossi, C.R.2    Lise, M.3    Nitti, D.4
  • 11
    • 21344459458 scopus 로고    scopus 로고
    • Therapeutic vaccination in patients with gastrointestinal malignancies. A review of immunological and clinical results
    • Mosolits S, Ullenhag G, Mellstedt H: Therapeutic vaccination in patients with gastrointestinal malignancies. A review of immunological and clinical results. Ann. Oncol. 16, 847-862 (2005).
    • (2005) Ann. Oncol , vol.16 , pp. 847-862
    • Mosolits, S.1    Ullenhag, G.2    Mellstedt, H.3
  • 12
    • 0346096827 scopus 로고    scopus 로고
    • The first 1000 dendritic cell vaccinees
    • Ridgway D: The first 1000 dendritic cell vaccinees. Cancer Invest. 21, 873-886 (2003).
    • (2003) Cancer Invest , vol.21 , pp. 873-886
    • Ridgway, D.1
  • 13
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon Alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected. stage IIB-III melanoma: Results of Intergroup Trial E1694/S9512/C509801
    • Kirkwood JM, Ibrahim JG, Sosman JA et al.: High-dose interferon Alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected. stage IIB-III melanoma: results of Intergroup Trial E1694/S9512/C509801. J. Clin. Oncol. 19, 2370-2380 (2001).
    • (2001) J. Clin. Oncol , vol.19 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3
  • 14
    • 0030000007 scopus 로고    scopus 로고
    • A Phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma
    • Goydos JS, Elder E, Whiteside TL, Finn OJ, Lotze MT: A Phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma. J. Surg. Res. 63, 298-304 (1996).
    • (1996) J. Surg. Res , vol.63 , pp. 298-304
    • Goydos, J.S.1    Elder, E.2    Whiteside, T.L.3    Finn, O.J.4    Lotze, M.T.5
  • 15
    • 0033985949 scopus 로고    scopus 로고
    • Adjuvant active specific immunotherapy for stage II and III colon cancer with an autologous tumor cell vaccine: Eastern Cooperative Oncology Group Study E5283
    • Harris JE, Ryan L, Hoover HC Jr et al.: Adjuvant active specific immunotherapy for stage II and III colon cancer with an autologous tumor cell vaccine: Eastern Cooperative Oncology Group Study E5283. J. Clin. Oncol. 18, 148-157 (2000).
    • (2000) J. Clin. Oncol , vol.18 , pp. 148-157
    • Harris, J.E.1    Ryan, L.2    Hoover Jr, H.C.3
  • 16
    • 7244243743 scopus 로고    scopus 로고
    • Trends in the risks and benefits to patients with cancer participating in Phase 1 clinical trials
    • Roberts TG, Goulart BH, Squitieri L et al.: Trends in the risks and benefits to patients with cancer participating in Phase 1 clinical trials. JAMA 292, 2130-2140 (2004).
    • (2004) JAMA , vol.292 , pp. 2130-2140
    • Roberts, T.G.1    Goulart, B.H.2    Squitieri, L.3
  • 17
    • 33645105886 scopus 로고    scopus 로고
    • Cancer immunotherapy using dendritic/tumour-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses
    • Homma S, Sagawa Y, Ito M, Ohno T, Toda G: Cancer immunotherapy using dendritic/tumour-fusion vaccine induces elevation of serum anti-nuclear antibody with better clinical responses. Clin. Exp. Immunol. 144, 41-47 (2006).
    • (2006) Clin. Exp. Immunol , vol.144 , pp. 41-47
    • Homma, S.1    Sagawa, Y.2    Ito, M.3    Ohno, T.4    Toda, G.5
  • 18
    • 22144433725 scopus 로고    scopus 로고
    • Towards therapeutic vaccines for colorectal carcinoma: A review of clinical trials
    • Mosolits S, Nilsson B, Mellstedt H: Towards therapeutic vaccines for colorectal carcinoma: a review of clinical trials. Expert Rev. Vaccines 4, 329-350 (2005).
    • (2005) Expert Rev. Vaccines , vol.4 , pp. 329-350
    • Mosolits, S.1    Nilsson, B.2    Mellstedt, H.3
  • 19
    • 27844458057 scopus 로고    scopus 로고
    • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: A phase I/II Study
    • Maker AV, Phan GQ, Attia P et al.: Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II Study. Ann. Surg. Oncol. 12, 1005-1016 (2005).
    • (2005) Ann. Surg. Oncol , vol.12 , pp. 1005-1016
    • Maker, A.V.1    Phan, G.Q.2    Attia, P.3
  • 20
    • 33846194189 scopus 로고    scopus 로고
    • MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model
    • Mukherjee P, Pathangey L, Bradley J et al.: MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model. Vaccine 25, 1607-1618 (2007).
    • (2007) Vaccine , vol.25 , pp. 1607-1618
    • Mukherjee, P.1    Pathangey, L.2    Bradley, J.3
  • 22
    • 0035339389 scopus 로고    scopus 로고
    • Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection
    • Soares MM, Mehta V, Finn OJ: Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection. J. Immunol. 166, 6555-6563 (2001).
    • (2001) J. Immunol , vol.166 , pp. 6555-6563
    • Soares, M.M.1    Mehta, V.2    Finn, O.J.3
  • 23
    • 13144268565 scopus 로고    scopus 로고
    • Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells
    • Gong J, Chen D, Kashiwaba M et al.: Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc. Natl Acad. Sci. USA 95(11), 6279-6283 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , Issue.11 , pp. 6279-6283
    • Gong, J.1    Chen, D.2    Kashiwaba, M.3
  • 24
    • 33746012881 scopus 로고    scopus 로고
    • Placebo-controlled Phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
    • Small EJ, Schellhammer PF, Higano CS et al.: Placebo-controlled Phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J. Clin. Oncol. 24, 3089-3094 (2006).
    • (2006) J. Clin. Oncol , vol.24 , pp. 3089-3094
    • Small, E.J.1    Schellhammer, P.F.2    Higano, C.S.3
  • 25
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP: Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10, 909-915 (2004).
    • (2004) Nat. Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 27
  • 28
    • 0036493712 scopus 로고    scopus 로고
    • Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: Clinical and immune responses in 35 patients
    • Timmerman JM, Czerwinski DK, Davis TA et al.: Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients. Blood 99, 1517-1526 (2002).
    • (2002) Blood , vol.99 , pp. 1517-1526
    • Timmerman, J.M.1    Czerwinski, D.K.2    Davis, T.A.3
  • 29
    • 33744815600 scopus 로고    scopus 로고
    • Clinical and immunologic responses to active specific cancer vaccines in human colorectal cancer
    • Nagorsen D, Thiel E: Clinical and immunologic responses to active specific cancer vaccines in human colorectal cancer. Clin. Cancer Res. 12, 3064-3069 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 3064-3069
    • Nagorsen, D.1    Thiel, E.2
  • 31
    • 33749189623 scopus 로고    scopus 로고
    • Improved overall survival in dendritic cell vaccination-induced immunoreactive subgroup of advanced melanoma patients
    • Ridolfi R, Petrini M, Fiammenghi L et al.: Improved overall survival in dendritic cell vaccination-induced immunoreactive subgroup of advanced melanoma patients. J. Transl. Med. 4, 36 (2006).
    • (2006) J. Transl. Med , vol.4 , pp. 36
    • Ridolfi, R.1    Petrini, M.2    Fiammenghi, L.3
  • 32
    • 33745223435 scopus 로고    scopus 로고
    • Vaccination of colorectal cancer patients with modified vaccinia ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: A Phase I/II trial
    • Harrop R, Connolly N, Redchenko I et al.: Vaccination of colorectal cancer patients with modified vaccinia ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a Phase I/II trial. Clin. Cancer Res. 12, 3416-3424 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 3416-3424
    • Harrop, R.1    Connolly, N.2    Redchenko, I.3
  • 33
    • 33646236935 scopus 로고    scopus 로고
    • Immune monitoring of T-cell responses in cancer vaccine development
    • Keilholz U, Marius P, Scheibenbogen C: Immune monitoring of T-cell responses in cancer vaccine development. Clin. Cancer Res. 12, S2346-S2352 (2006).
    • (2006) Clin. Cancer Res , vol.12
    • Keilholz, U.1    Marius, P.2    Scheibenbogen, C.3
  • 34
    • 0027512782 scopus 로고
    • Adjuvant active specific immunotherapy for human colorectal cancer: 6.5-year median follow-up of a Phase III prospectively randomized trial
    • Hoover HC Jr, Brandhorst JS, Peters LC et al.: Adjuvant active specific immunotherapy for human colorectal cancer: 6.5-year median follow-up of a Phase III prospectively randomized trial. J. Clin. Oncol. 11, 390-399 (1993).
    • (1993) J. Clin. Oncol , vol.11 , pp. 390-399
    • Hoover Jr, H.C.1    Brandhorst, J.S.2    Peters, L.C.3
  • 35
    • 0033616482 scopus 로고    scopus 로고
    • Active specific immunotherapy fbr stage II and stage III human colon cancer: A randomized trial
    • Vermorken JB, Claessen AM, van Tinteren H et al.: Active specific immunotherapy fbr stage II and stage III human colon cancer: a randomized trial. Lancet 353, 345-350 (1999).
    • (1999) Lancet , vol.353 , pp. 345-350
    • Vermorken, J.B.1    Claessen, A.M.2    van Tinteren, H.3
  • 36
    • 0035925638 scopus 로고    scopus 로고
    • Adjuvant active specific inummotherapy of stage II and stage III colon cancer with an autologous tumor cell vaccine: First randomized Phase III trials show promise
    • Hanna MG Jr, Hoover HC Jr, Vermorken JB, Harris JE, Pinedo HM: Adjuvant active specific inummotherapy of stage II and stage III colon cancer with an autologous tumor cell vaccine: first randomized Phase III trials show promise. Vaccine 19, 2576-2582 (2001).
    • (2001) Vaccine , vol.19 , pp. 2576-2582
    • Hanna Jr, M.G.1    Hoover Jr, H.C.2    Vermorken, J.B.3    Harris, J.E.4    Pinedo, H.M.5
  • 37
    • 0037349751 scopus 로고    scopus 로고
    • Application of autologous tumor cell vaccine and NDV vaccine in treatment of tumors of digestive tract
    • Liang W, Wang H, Sun TM et al.: Application of autologous tumor cell vaccine and NDV vaccine in treatment of tumors of digestive tract. World J. Gastroenterol. 9, 495-498 (2003).
    • (2003) World J. Gastroenterol , vol.9 , pp. 495-498
    • Liang, W.1    Wang, H.2    Sun, T.M.3
  • 38
    • 17844367837 scopus 로고    scopus 로고
    • Randomized double-blind Phase II survival study comparing immunization with the anti-idiotypic monoclonal antibody 105AD7 against placebo in advanced colorectal cancer
    • Maxwell-Armstrong CA, Durrant LG, Buckley TJ et al.: Randomized double-blind Phase II survival study comparing immunization with the anti-idiotypic monoclonal antibody 105AD7 against placebo in advanced colorectal cancer. Br. J. Cancer 84, 1443-4446 (2001).
    • (2001) Br. J. Cancer , vol.84 , pp. 1443-4446
    • Maxwell-Armstrong, C.A.1    Durrant, L.G.2    Buckley, T.J.3
  • 39
    • 0031457133 scopus 로고    scopus 로고
    • Antibody and T-cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein
    • Karanikas V, Hwang LA, Pearson J et al.: Antibody and T-cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein. J. Clin. Invest. 100, 2783-2792 (1997).
    • (1997) J. Clin. Invest , vol.100 , pp. 2783-2792
    • Karanikas, V.1    Hwang, L.A.2    Pearson, J.3
  • 40
    • 32944475905 scopus 로고    scopus 로고
    • Mannan-MUC1-pulsed dendritic cell immunotherapy: A Phase I trial in patients with adenocarcinoma
    • Loveland BE, Zhao A, White S et al.: Mannan-MUC1-pulsed dendritic cell immunotherapy: a Phase I trial in patients with adenocarcinoma. Clin. Cancer Res. 12, 869-877 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 869-877
    • Loveland, B.E.1    Zhao, A.2    White, S.3
  • 41
    • 34347403138 scopus 로고    scopus 로고
    • Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells fbr tumor immumotherapy
    • Fong L, Hou Y, Rivas A et al.: Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells fbr tumor immumotherapy. Proc. Natl Acad. Sci. USA 11, 6342-6351 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.11 , pp. 6342-6351
    • Fong, L.1    Hou, Y.2    Rivas, A.3
  • 42
    • 20044364936 scopus 로고    scopus 로고
    • Phase I study of sequential vaccinations with fowlpox-CEA (6D)-TRICOM alone and sequentially with vaccinia-CEA (6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas
    • Marshall JL, Gulley JL, Arlen PM et al.: Phase I study of sequential vaccinations with fowlpox-CEA (6D)-TRICOM alone and sequentially with vaccinia-CEA (6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. J. Clin. Oncol. 23, 720-731 (2005).
    • (2005) J. Clin. Oncol , vol.23 , pp. 720-731
    • Marshall, J.L.1    Gulley, J.L.2    Arlen, P.M.3
  • 43
    • 0344305415 scopus 로고    scopus 로고
    • Premalignant lesions as targets for cancer vaccines
    • Finn OJ: Premalignant lesions as targets for cancer vaccines. J. Exp. Med. 198(11), 1623-1626 (2003).
    • (2003) J. Exp. Med , vol.198 , Issue.11 , pp. 1623-1626
    • Finn, O.J.1
  • 44
    • 4344587783 scopus 로고    scopus 로고
    • American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer
    • Benson AB III, Schrag D, Somerfield MR et al.: American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J. Clin. Oncol. 22, 3408-3419 (2004).
    • (2004) J. Clin. Oncol , vol.22 , pp. 3408-3419
    • Benson III, A.B.1    Schrag, D.2    Somerfield, M.R.3
  • 45
    • 0036787781 scopus 로고    scopus 로고
    • Adjuvant chemotherapy use for medicare beneficiaries with stage II colon cancer
    • Schrag D, Rifas-Shiman S, Saltz L, Bach PB, Begg CB: Adjuvant chemotherapy use for medicare beneficiaries with stage II colon cancer. J. Clin. Oncol. 20, 3999-4005 (2002).
    • (2002) J. Clin. Oncol , vol.20 , pp. 3999-4005
    • Schrag, D.1    Rifas-Shiman, S.2    Saltz, L.3    Bach, P.B.4    Begg, C.B.5
  • 46
    • 27244438238 scopus 로고    scopus 로고
    • Clinical trial designs for therapeutic cancer vaccines
    • Khleif S Ed, Kluwer Academic Publishers, MA, USA
    • Simon R: Clinical trial designs for therapeutic cancer vaccines. In: Tumor immunology and cancer vaccines. Khleif S (Ed). Kluwer Academic Publishers, MA, USA, 339-350 (2005).
    • (2005) Tumor immunology and cancer vaccines , pp. 339-350
    • Simon, R.1
  • 47
    • 33644760431 scopus 로고    scopus 로고
    • A randomized Phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer
    • Arlen PM, Gulley JL, Parker C et al.: A randomized Phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer. Clin. Cancer Res. 12(4), 1260-1269 (2006).
    • (2006) Clin. Cancer Res , vol.12 , Issue.4 , pp. 1260-1269
    • Arlen, P.M.1    Gulley, J.L.2    Parker, C.3
  • 48
    • 32944468708 scopus 로고    scopus 로고
    • Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer
    • Antonia SJ, Mirza N, Fricke I et al.: Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer Clin Cancer Res. 12(3 Pt 1), 878-887 (2006).
    • (2006) Clin Cancer Res , vol.12 , Issue.3 PART 1 , pp. 878-887
    • Antonia, S.J.1    Mirza, N.2    Fricke, I.3
  • 49
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumor immunity and immunotherapy
    • Zou W: Regulatory T cells, tumor immunity and immunotherapy. Nat. Rev. Immunol. 6, 295-307 (2006).
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 295-307
    • Zou, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.