Tocolytic effect of parecoxib, a new parenteral cyclo-oxygenase-2-specific inhibitor, on the spontaneous and prostaglandin-induced contractions of rat isolated myometrium

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 8, 2007, Pages 737-741

  Ayar, A ^a  

^a FIRAT UNIVERSITY   (Turkey)

Author keywords

Contractility; Cyclo oxygenase 2 inhibitors; Myometrium; Parecoxib; Prostaglandin F2 ; Rat

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; PARECOXIB; PROSTAGLANDIN F2 ALPHA;

ANALYSIS OF VARIANCE; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DECAPITATION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DYSMENORRHEA; FEMALE; IN VITRO STUDY; MUSCLE ISOMETRIC CONTRACTION; MYOMETRIUM; NONHUMAN; PREMATURE LABOR; QUANTITATIVE ANALYSIS; RAT; SMOOTH MUSCLE TONE; TOCOLYSIS; UTERUS CONTRACTION;

ANIMALS; AREA UNDER CURVE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROST; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ISOMETRIC CONTRACTION; ISOXAZOLES; MYOMETRIUM; RATS; RATS, WISTAR; TIME FACTORS; TOCOLYTIC AGENTS; UTERINE CONTRACTION;

EID: 34347357479     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04632.x     Document Type: Article

References (32)

1. Funk CD. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 2001 294 : 1871 5.
2. Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: The biology of prostaglandin synthesis and inhibition. Pharmacol. Rev. 2004 56 : 387 437.
3. Challis JR, Lye SJ, Gibb W. Prostaglandins and parturition. Ann. N.Y. Acad. Sci. 1997 828 : 254 67.
4. Slater DM, Zervou S, Thornton S. Prostaglandins and prostanoid receptors in human pregnancy and parturition. J. Soc. Gynecol. Invest. 2002 9 : 118 24.
5. Hawkey CJ. COX-2 inhibitors. Lancet 1999 353 : 307 14.
6. Chandrasekharan NV, Dai H, Roos KL et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc. Natl Acad. Sci. USA 2002 99 : 13 926 31.
7. Marnett LJ. Cyclooxygenase mechanisms. Curr. Opin. Chem. Biol. 2000 4 : 545 52.
8. Marnett LJ, Kalgutkar AS. Cyclooxygenase 2 inhibitors: Discovery, selectivity and the future. Trends Pharmacol. Sci. 1999 20 : 465 9.
9. Kniss DA. Cyclooxygenases in reproductive medicine and biology. J. Soc. Gynecol. Invest. 1999 6 : 285 92.
10. Hayes EC, Rock JA. COX-2 Inhibitors and their role in gynecology. Obstet. Gynecol. Surv. 2002 57 : 768 80.
11. Xie WL, Chipman JG, Robertson DL, Erikson RL, Simmons DL. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl Acad. Sci. USA 1991 88 : 2692 6.
12. Brosens JJ, Mak I, Brosens I. Mechanisms of dysmenorrhoea. In : O'Brien S, Cameron IT, MacLean A (eds). Disorders of the Menstrual Cycle. RCOG Press, London. 2000 113 32.
13. Jabbour HN, Sales KJ. Prostaglandin receptor signalling and function in human endometrial pathology. Trends Endocrinol. Metab. 2004 15 : 398 404.
14. Yousif MH, Thulesius O. Tocolytic effect of the cyclooxygenase-2 inhibitor, meloxicam: Studies on uterine contractions in the rat. J. Pharm. Pharmacol. 1998 50 : 681 5.
15. Slattery MM, Friel AM, Healy DG, Morrison JJ. Uterine relaxant effects of cyclooxygenase-2 inhibitors in vitro. Obstet. Gynecol. 2001 98 : 563 9.
16. Doret M, Mellier G, Benchaib M, Piacenza JM, Gharib C, Pasquier JC. In vitrostudy of tocolytic effect of rofecoxib, a specific cyclo-oxygenase 2 inhibitor. Comparison and combination with other tocolytic agents. Br. J. Obsts. Gynaecol. 2002 109 : 983 8.
17. Cheer SM, Goa KL. Parecoxib (parecoxib sodium). Drugs 2001 61 : 1133 41.
18. Barton SF, Langeland FF, Snabes MC et al. Efficacy and safety of intravenous parecoxib sodium in relieving acute postoperative pain following gynecologic laparotomy surgery. Anesthesiology 2002 97 : 306 14.
19. Edwards JE, McQuay HJ, Moore RA. Oral valdecoxib and injected parecoxib for acute postoperative pain: A quantitative systematic review. BMC Anesthesiol. 2003 3 : 1.
20. Institute for Laboratory Animal Research National Research Council. Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC. 1996.
21. Ayar A, Kutlu S, Yilmaz B, Kelestimur H. Melatonin inhibits spontaneous and oxytocin-induced contractions of rat myometrium in vitro. Neuroendocrinol. Lett. 2001 22 : 199 207.
22. Slater DM, Dennes WJ, Campa JS, Poston L, Bennett PR. Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy. Mol. Hum. Reprod. 1999 5 : 880 4.
23. Zuo J, Lei ZM, Rao CV, Pietrantoni M, Cook VD. Differential cyclooxygenase-1 and -2 gene expression in human myometria from preterm and term deliveries. J. Clin. Endocrinol. Metab. 1994 79 : 894 9.
24. Williams KI, Vane JR. Inhibition of uterine motility. The possible role of the prostaglandins and aspirin-like drugs. Pharmacol. Ther. 1975 1 : 89 113.
25. Johnson WL, Harbert GM, Martin CB. Pharmacologic control of uterine contractility. In vitrohuman and in vivomonkey studies. Am. J. Obstet. Gynecol. 1975 123 : 364 75.
26. King J, Flenady V, Cole S, Thornton S. Cyclo-oxygenase (COX) inhibitors for treating preterm labour. Cochrane Database Syst. Rev. 2005 2 : CD001992.
27. Alvin PE, Litt IF. Current status of the etiology and management of dysmenorrhea in adolescence. Pediatrics 1982 70 : 516 25.
28. Tzafettas J. Painful menstruation. Pediatr. Endocrinol. Rev. 2006 1 : 160 3.
29. Andrea JR. Pelvic pain and dysmenorrhea. In : Berek JS, Adashi E, Hillard PA (eds). Novak's Gynecology, 12th edn. Williams & Wilkins, Baltimore. 1996 399 426.
30. Maxwell M, Nathanson M. Parecoxib: Getting to the heart of the matter. Anaesthesia 2006 61 : 823 5.
31. Stichtenoth DO, Frolich JC. The second generation of COX-2 inhibitors: What advantages do the newest offer? Drugs 2003 63 : 33 45.
32. Koppert W, Frotsch K, Huzurudin N et al. The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery. Anesth. Analg. 2006 103 : 1170 6.