FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity

Cancer Letters

Volumn 253, Issue 2, 2007, Pages 265-272

  Jiang, Feng ^a   Ai, Junkui ^b   Xiao, Wuhan ^a,b,c   Wang, Zhou ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c INSTITUTE OF HYDROBIOLOGY   (China)

Author keywords

EAF1; ELL; FB1; U19 EAF2

Indexed keywords

COMPLEMENTARY DNA; ELL ASSOCIATED FACTOR 2; FB1 PROTEIN; PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EAF1; TRANSCRIPTION FACTOR EAF2; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADVANCED CANCER; ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CHILDHOOD LEUKEMIA; DNA BINDING; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; TWO HYBRID SYSTEM; UPREGULATED GENE 19;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; IMMUNOPRECIPITATION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ELONGATION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 34347341515     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.02.003     Document Type: Article

References (22)

1. Wang Z., Tufts R., Haleem R., and Cai X. Genes regulated by androgen in the rat ventral prostate. Proc. Natl. Acad. Sci. USA 94 24 (1997) 12999-13004
2. Xiao W., Zhang Q., Jiang F., Pins M., Kozlowski J.M., and Wang Z. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Cancer Res. 63 15 (2003) 4698-4704
3. Simone F., Luo R.T., Polak P.E., Kaberlein J.J., and Thirman M.J. ELL-associated factor 2(EAF2), a functional homolog of EAF1 with alternative ELL binding properties. Blood 101 6 (2003) 2355-2362
4. Thirman M.J., Levitan D.A., Kobayashi H., Simon M.C., and Rowley J.D. Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p 13.1) in acute myeloid leukemia. Proc. Natl. Acad. Sci. USA 91 25 (1994) 12110-12114
5. Shilatifard A., Lane W.S., Jackson K.W., Conaway R.C., and Conaway J.W. An RNA polymerase II elongation factor encoded by the human ELL gene. Science 271 5257 (1996) 1873-1876
6. Simone F., Polak P.E., Kaberlein J.J., Luo R.T., Levitan D.A., and Thirman M.J. EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein. Blood 98 1 (2001) 201-209
7. Li M., Wu X., Zhuang F., Jiang S., Jiang M., and Liu Y.H. Expression of murine ELL-associated factor 2 (Eaf2) is developmental regulated. Dev. Dyn. 228 2 (2003) 273-280
8. Saso K., Ito T., Natori S., and Sekimizu K. Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factoS-II. J. Biochem. (Tokyo) 133 4 (2003) 493-500
9. Kong S.E., Banks C.A., Shilatifard A., Conaway J.W., and Conaway R.C. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc. Natl. Acad. Sci. USA 102 29 (2005) 10094-10098
10. Brambillasca F., Mosna G., Colombo M., Rivolta A., Caslini C., Minuzzo M., Giudici G., Mizzi L., Biondi A., and Privitera E. Identification of a novel molecular partner of the E2A gene in childhood leukemia. Leukemia 13 3 (1999) 369-375
11. Kee B.L., Quong M.W., and Murre C. E2A proteins: essential regulators at multiple stages of B-cell development. Immunol. Rev. 175 (2000) 138-149
12. Irie Y., Yamagata K., Gan Y., Miyamoto K., Do E., Kuo C.H., Taira E., and Miki N. Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes celldeath in cultured cells. J. Biol. Chem. 275 4 (2000) 2647-2653
13. Gan Y., Taira E., Irie Y., Fujimoto T., and Miki N. Arrest of cell cycle by amida which is phosphorylated by Cdc2 kinase. Mol. Cell Biochem. 246 1-2 (2003) 179-185
14. Gan Y., Taira E., Irie Y., Tanaka H., Ichikawa H., Kumamaru E., and Miki N. Amida predominantly expressed and developmentally regulated in rat testis. Biochem. Biophys. Res. Commun. 288 2 (2001) 407-412
15. Boosen M., Vetterkind S., Koplin A., Illenberger S., and Preuss U. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis. Exp. Cell Res. 311 2 (2005) 177-191
16. Nakano K., and Vousden K.H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7 3 (2001) 683-694
17. Johnstone R.W., Gerber M., Landewe T., Tollefson A., Wold W.S., and Shilatifard A. Functional analysis of the leukemia protein ELL: evidence for a role in the regulation of cell growth and survival. Mol. Cell Biol. 21 5 (2001) 1672-1681
18. Jiang F., Yang L., Cai X., Cyriac J., Shechter I., and Wang Z. Farnesyl diphosphate synthase is abundantly expressed and regulated by androgen in rat prostatic epithelial cells. J. Steroid. Biochem. Mol. Biol. 78 2 (2001) 123-130
19. Hahn J., Xiao W., Jiang F., Simone F., Thirman M.J., and Wang Z. Apoptosis induction and growth suppression by U19 is mediated through its ELL-binding domain. Prostate 67 2 (2007) 146-153
20. Xiao W., Jiang F., and Wang Z. ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. Prostate 66 1 (2006) 1-12
21. Polak P.E., Simone F., Kaberlein J.J., Luo R.T., and Thirman M.J. ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia. Mol. Biol. Cell 14 4 (2003) 1517-1528
22. Mitani K., Yamagata T., Iida C., Oda H., Maki K., Ichikawa M., Asai T., Honda H., Kurokawa M., and Flirai H. Nonredundant roles of the elongation factor MEN in postimplantation development. Biochem. Biophys. Res. Commun. 279 2 (2000) 563-567