ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties

Blood

Volumn 101, Issue 6, 2003, Pages 2355-2362

  Simone, Federico ^a   Luo, Roger T ^a   Polak, Paul E ^a   Kaberlein, Joseph J ^a   Thirman, Michael J ^a  

^a SECTION OF HEMATOLOGY ONCOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; ELONGATION FACTOR; GENE PRODUCT; GLUTAMIC ACID; HYBRID PROTEIN; PROTEIN EAF1; PROTEIN EAF2; PROTEIN ELL; RNA POLYMERASE II; SERINE; UNCLASSIFIED DRUG;

ACUTE LEUKEMIA; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL IMMORTALIZATION; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION 11; CONTROLLED STUDY; GENETIC CONSERVATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

EID: 0037443468     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-06-1664     Document Type: Article

References (20)

1. Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD. Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci U S A. 1994;91:12110-12114.
2. Shilatifard A, Lane WS, Jackson, KW, Conaway RC, Conaway JW. An RNA polymerase II elongation factor encoded by the human ELL gene. Science. 1996;271:1873-1876.
3. Shilatifard A, Duan DR, Haque D, Florence C, Schubach WH, Conaway JW. ELL2, a new member of an ELL family of RNA Polymerase II elongation factors. Proc Natl Acad Sci U S A. 1997;94:3639-3643.
4. Conaway JW, Shilatifard A, Dvir A, Conaway RC. Control of elongation by RNA polymerase II. TIBS. 2000;25:375-380.
5. Thirman MJ, Gill HJ, Burnett RC, et al. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11 q23 chromosomal translocations. N Engl J Med. 1993;329:909-914.
6. DiMartino JF, Cleary ML. MLL rearrangements in haematological malignancies: lessons from clinical and biological studies. Br J Haematol. 1999;106:614-626.
7. Tkachuk DC, Kohler S, Cleary ML. Involvement of a homolog of Drosophila Trithorax by 11q23 chromosomal translocations in acute leukemias. Cell. 1992;71:691-700.
8. Nakamura T, Alder H, Gu Y, et al. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci U S A. 1993;90:4631-4635.
9. Domer PH, Fakharzadeh SS, Chen CS, et al. Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc Natl Acad Sci U S A. 1993;90:7884-7888.
10. Taki T, Kano H, Taniwaki M, Sako M, Yanagisawa M, Hayashi Y. AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Proc Natl Acad Sci U S A. 1999;96:14535-14540.
11. Ma C, Staudt LM. LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood. 1996;87:734-745.
12. Prasad R, Yano T, Sorio C, et al. Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia. Proc Natl Acad Sci U S A. 1995;92:12160-12164.
13. Rubnitz JE, Morrissey J, Savage PA, Cleary ML. ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells. Blood. 1994;84:1747-1752.
14. Simone F, Polak PE, Luo RT, Kaberlein JJ, Levitan DA, Thirman MJ. EAF1, a novel ELL associated factor that is delocalized by expression of the MLL-ELL fusion protein. Blood. 2001;98:201-209.
15. Lavau C, Luo RT, Du C, Thirman MJ. Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. Proc Natl Acad Sci U S A. 2000;97:10984-10989.
16. Luo RT, Lavau C, Du C, et al. The elongation domain of ELL is dispensable but its EAF1 interaction domain is essential for MLL-ELL induced leukemogenesis. Mol Cell Biol. 2001;21:5678-5687.
17. Gietz RD, Triggs-Raine B, Robbins A, Graham KC, Woods RA. Identification of proteins that interact with a protein of interest: applications of the yeast two-hybrid system. Mol Cell Biochem. 1997;172:67-79.
18. Altschul SF, Gish W. Local alignment statistics. Methods Enzymol. 1996;26:460-480.
19. Thirman MJ, Diskin EB, Bin SS, lp HS, Miller JM, Simon MC. Developmental analysis and subcellular localization of the murine homologue of ELL. Proc Natl Acad Sci U S A. 1997;94:1408-1413.
20. Kamura T, Burian D, Khalili H, et al. Cloning and characterization of ELL-associated proteins EAP45 and EAP20: a role for yeast EAP-like proteins in regulation of gene expression by glucose. J Biol Chem. 2001;276:16528-16533.