Prophylactic effect of glutamine and marzulene against Helicobacter pylori-related gastric diseases in Mongolian gerbils

Japanese Pharmacology and Therapeutics

Volumn 35, Issue 5, 2007, Pages 479-488

  Nakamura, Eiji ^a   Hayashi, Shusaku ^a   Amagase, Kikuko ^a   Okabe, Susumu ^a   Endo, Takuya ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Ammonia; Glutamine; Hp related gastric diseases; Marzulene; Mongolian gerbil; Protection

Indexed keywords

AMINO ACID DERIVATIVE; AMMONIUM CHLORIDE; CHEMOKINE; CRYSTAL VIOLET; GLUTAMINE; MARZULENE; NEUTRAL RED; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; CELL LINE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIETARY INTAKE; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; EDEMA; GASTRITIS; GERBIL; HELICOBACTER PYLORI; IN VITRO STUDY; IN VIVO CULTURE; METAPLASIA; NONHUMAN; RAT; STOMACH DISEASE; STOMACH EPITHELIUM; STOMACH EROSION; STOMACH MUCOSA; STOMACH ULCER;

EID: 34347335805     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. JAMA 1994 ; 272 : 65-9.
2. Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest 2007 ; 117 : 60-9.
3. Murakami K and Fujioka T. Drug resistant H. pylori in Japan : general remarks. Nippon Rinsho 2005 ; 63 (Suppl 11) : 198-202.
4. Takahashi S, Tokunaga K, Tanaka A. Generalization of Helicobacter pylori eradication therapy and its future in Japan. Kansenshogaku Zasshi 2006 ; 80 : 203-11.
5. Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China : a randomized controlled trial. Ja 2004 ; 291 : 187-94.
6. Fujikawa A, Shirasaka D, Yamamoto S, Ota H, Yahiro K, Fukada M, et al. Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Nat Genet 2003 ; 33 : 375-81.
7. Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci USA 2002 ; 99 : 14428-33.
8. Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Higashi H, Hatakeyama M, et al. The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa. J Infect Dis 2003 ; 187 : 334-7.
9. Dekigai H, Murakami M, and Kita T. Mechanism of Helicobacter pylori- associated gastric mucosal injury. Dig Dis Sci 1995 ; 40 : 1332-9.
10. Kawano S, Tsujii M, Fusamoto H, Sato N, Kamada T. Chronic effect of intragastric ammonia on gastric mucosal structures in rats. Dig Dis Sci 1991 ; 36 : 33-8.
11. Matsui T, Matsukawa Y, Sakai T, Nakamura K, Aoike A, Kawai K. Ammonia inhibits proliferation and cell cycle progression at S-phase in human gastric cells. Dig Dis Sci 1997 ; 42 : 1394-9.
12. Suzuki H, Yanaka A, Muto H. Luminal ammonia retards restitution of guinea pig injured gastric mucosa in vitro. Am J Physiol 2000 ; 279 : G107-17.
13. Tsujii M, Kawano S, Tsuji S, Fusamoto H, Kamada T, Sato N. Mechanism of gastric mucosal damage induced by ammonia. Gastroenterology 1992 ; 102 : 1881-8.
14. Tsujii M, Kawano S, Tsuji S, Ito T, Nagano K, Sasaki Y, et al. Cell kinetics of mucosal atrophy in rat stomach induced by long-term administration of ammonia. Gastroenterology 1993 ; 104 : 796-801.
15. Akanuma M, Maeda S, Ogura K, Mitsuno Y, Hirata Y, Ikenoue T, et al. The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model. J Infect Dis 2002 ; 185 : 341-7.
16. Israel DA, Salama N, Arnold CN, Moss SF, Ando T, Wirth HP, et al. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J Clin Invest 2001 ; 107 : 611-20.
17. Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T, et al. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. J Exp Med 2000 ; 192 : 1601-10.
18. Shibata W, Hirata Y, Maeda S, Ogura K, Ohmae T, Yanai A, et al. CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model. J Pathol 2006 ; 210 : 306-14.
19. Fox JG. Review article : Helicobacter species and in vivo models of gastrointestinal cancer. Aliment Pharmacol Ther 1998 ; 12 (Suppl 1) : 37-60.
20. Fox JG, Wang TC, Rogers AB, Poutahidis T, Ge Z, Taylor N, et al. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology 2003 ; 124 : 1879-90.
21. Eaton KA, Brooks CL, Morgan DR, Krakowka S. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun 1991 ; 59 : 2470-5.
22. Perez-Perez GI, Olivares AZ, Cover TL, Blaser MJ. Characteristics of Helicobacter pylori variants selected for urease deficiency. Infect Immun 1992 ; 60 : 3658-63.
23. Nakamura E, Hagen SJ. Role of glutamine and arginase in protection against ammonia-induced cell death in gastric epithelial cells. Am J Physiol 2002 ; 283 : G1264-75.
24. Ito M, Yokochi E, Kobayashi C, Suzuki Y. Studies on defensive factors of experimental ulcers (2) : increasing action of aceglutamide aluminum on defensive factors in acetic acid ulcers of rats (author's transl). Nippon Yakurigaku Zasshi 1982 ; 79 : 327-34.
25. Okabe S, Honda K, Takeuchi K, Takagi K. Inhibitory effect of L-glutamine on gastric irritation and back diffusion of gastric acid in response to aspirin in the rat. Am J Dig Dis 1975 ; 20 : 626-31.
26. Okabe S, Otsu K, Takeuchi K, Takagi K. Effect of L-glutamine on indomethacin-induced gastric lesions in the rat. Jpn J Pharmacol 1974 ; 24 : 169-71.
27. Okabe S, Takeuchi K, Honda K, Takagi K. Effects of acetylsalicylic acid (ASA), ASA plus L-glutamine and L-glutamine on healing of chronic gastric ulcer in the rat. Digestion 1976 ; 14 : 85-8.
28. Okabe S, Takeuchi K, Nakamura K, Takagi K. Inhibitory effect of L-glutamine on the aspirin-induced gastric lesions in the rat. J Pharm Pharmacol 1974 ; 26 : 605-11.
29. Okabe S, Takeuchi K, Takata Y, Naganuma T, Takagi K. Effects of L-glutamine on various gastric lesions in rats and guinea pigs. Digestion 1976 ; 14 : 325-31.
30. Hagen SJ, Takahashi S, Jansons R. Role of vacuolation in the death of gastric epithelial cells. Am J Physiol 1997 ; 272 : C48-58.
31. Takahashi S, Keto Y, Fujita H, Muramatsu H, Nishino T, Okabe S. Pathological changes in the formation of Helicobacter pylori-induced gastric lesions in Mongolian gerbils. Dig Dis Sci 1998 ; 43 : 754-65.
32. Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M. Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology 1998 ; 115 : 642-8.
33. Keto Y, Ebata M, Okabe S. Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils. Nippon Yakurigaku Zasshi 2001 ; 118 : 259-68.
34. Stark RM, Suleiman MS, Hassan IJ, Greenman J, Millar MR. Amino acid utilisation and deamination of glutamine and asparagine by Helicobacter pylori. J Med Microbiol 1997 ; 46 : 793-800.
35. Chang WK, Yang KD, Shaio MF. Effect of glutamine on Th1 and Th2 cytokine responses of human peripheral blood mononuclear cells. Clin Immunol 1999 ; 93 : 294-301.
36. Yeh CL, Hsu CS, Yeh SL, Chen WJ. Dietary glutamine supplementation modulates Th1/Th2 cytokine and interleukin-6 expressions in septic mice. Cytokine 2005 ; 31 : 329-34.
37. Yeh SL, Lai YN, Shang HF, Lin MT, Chiu WC, Chen WJ. Effects of glutamine supplementation on splenocyte cytokine mRNA expression in rats with septic peritonitis. World J Gastroenterol 2005 ; 11 : 1742-6.
38. Whary MT, Fox JG. Th1-mediated pathology in mouse models of human disease is ameliorated by concurrent Th2 responses to parasite antigens. Curr Top Med Chem 2004 ; 4 : 531-8.