In vivo assessment of safety and mechanisms underlying in vitro relaxation induced by Mikania laevigata Schultz Bip. ex Baker in the rat trachea

Journal of Ethnopharmacology

Volumn 112, Issue 3, 2007, Pages 430-439

  Graça, Carlos ^a   Baggio, Cristiane Hatsuko ^b   Freitas, Cristina Setim ^b   Rattmann, Yanna Dantas ^b   de Souza, Lauro Mera ^a   Cipriani, Thales Ricardo ^a   Sassaki, Guilherme Lanzi ^a   Rieck, Lia ^b   Pontarolo, Roberto ^a   da Silva Santos, José Eduardo ^a   Marques, Maria Consuelo Andrade ^b  

^a FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Asteraceae; Guaco syrup; Mikania laevigata; Relaxation; Toxicity

Indexed keywords

CALCIUM; COUMARIN; GUACO SYRUP; MIKANIA LAEVIGATA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; FEMALE; LD 50; MALE; MIKANIA; MIKANIA LAEVIGATA; MOUSE; NONHUMAN; RAT; SWISS WEBSTER MOUSE; TOXICITY TESTING; TRACHEA; WISTAR RAT;

4-AMINOPYRIDINE; ACETYLCHOLINE; ACUTE TOXICITY TESTS; ANIMALS; BRAZIL; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYBURIDE; MALE; MICE; MIKANIA; MUSCLE RELAXATION; MUSCLE, SMOOTH; NG-NITROARGININE METHYL ESTER; OXADIAZOLES; PLANT EXTRACTS; POTASSIUM CHANNEL BLOCKERS; QUINOXALINES; RATS; RATS, WISTAR; TETRAETHYLAMMONIUM; TOXICITY TESTS, CHRONIC; TRACHEA;

ASTERACEAE; MIKANIA CONGESTA; MIKANIA LAEVIGATA; MUS; RATTUS; RODENTIA;

EID: 34347335753     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.03.026     Document Type: Article

References (32)

1. Adda S., Fleischmann B.K., Freedman B.D., Yu M., Hay D.W., and Kotlikoff M.I. Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle. Journal of Biological Chemistry 271 (1996) 13239-13243
2. Agência Nacional de Vigilância Sanitária-ANVISA, 2000. RDC no. 17 de 24 de fevereiro de 2000, Registro de Medicamentos Fitoterápicos. Dispõe sobre o registro de medicamentos fitoterápicos. D.O. no. 40-E, Seção 1, Brasília, p. 25.
3. 2+ entry in porcine airway smooth muscle. American Journal of Physiology 286 (2004) L909-L919
4. Baliga M.S., Jagetia G.C., Ulloor J.N., Baliga M.P., Venkatesh P., Reddy R., Rao K.V., Baliga B.S., Devi S., Raju S.K., Veeresh V., Reddy T.K., and Bairy K.L. The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats. Toxicology Letters 151 (2004) 317-326
5. Benoit C., Renaudon B., Salvail D., and Rousseau E. EETs relax airway smooth muscle via an EpDHF effect: BK (Ca) channel activation and hyperpolarization. American Journal of Physiology 280 (2001) L965-L973
6. Bergner A., and Sanderson M.J. Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices. Journal of General Physiology 119 (2002) 187-198
7. Bialecki R.A., and Stinson-Fisher C. KCa channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle. American Journal of Physiology 268 Pt1 (1995) L152-L159
8. Bighetti A.E., Antonio M.A., Kohn L.K., Rehder V.L., Foglio M.A., Possenti A., Vilela L., and Carvalho J.E. Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz. Phytomedicine 12 (2005) 72-77
9. Chiu C.C., Chen Y.W., Wu J.R., Lin Y.T., Chen I.J., and Yeh J.L. KMUP 880708: a vanyllilamide-based β1-adrenoceptor antagonist with a-adrenoceptor blocking and potassium channel opening activities. Drug Development Research 55 (2002) 104-117
10. Coimbra R. Notas de Fitoterapia (1942), Laboratório Clínico Silva Araújo, Rio de Janeiro
11. Cortijo J., Sarria B., Pedros C., Perpina M., Paris F., and Morcillo E. The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle. Naunyn-Schmiedeberg's Archives of Pharmacology 346 (1992) 462-468
12. Dai J.M., Kuo K.H., Leo J.M., van Breemen C., and Lee C.H. Mechanism of ACh-induced asynchronous calcium waves and tonic contraction in porcine tracheal muscle bundle. American Journal of Physiology 290 (2006) L459-L469
13. Davino S.C., Giesbrecht A.M., and Roque N.F. Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15. Brazilian Journal of Medical and Biological Research 22 (1989) 1127-1129
14. De Carvalho Osorio A., and Martins J.L.S. Determination of coumarin in fluid extract and tinture of "guaco" by first derivative spectrophotometry. Brazilian Journal of Pharmaceutical Sciences 40 (2004) 481-486
15. Dimitropoulou C., White R.E., Ownby D.R., and Catravas J.D. Estrogen reduces carbachol-induced constriction of asthmatic airways by stimulating large-conductance voltage and calcium-dependent potassium channels. American Journal of Respiratory Cell and Molecular Biology 32 (2005) 239-247
16. Du W., Stiber J.A., Rosenberg P.B., Meissner G., and Eu J.P. Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. Journal of Biological Chemistry 280 (2005) 26287-26294
17. Graça C., Freitas C.S., Baggio C.H., Dalsenter P.R., and Marques M.C.A. Mikania laevigata syrup does not induce side effects on reproductive system of male Wistar rats. Journal of Ethnopharmacology 111 (2007) 29-32
18. Kannan M.S., and Johnson D.E. Modulation of nitric oxide-dependent relaxation of pig tracheal smooth muscle by inhibitors of guanylyl cyclase and calcium activated potassium channels. Life Sciences 56 (1995) 2229-2238
19. Knight J.A. Liver function tests: their role in the diagnosis of hepatobiliary diseases. Journal of Infusion Nursing 28 (2005) 108-117
20. Leite M.G.R., Souza C.L., Silva M.A.M., Moreira L.K.A., Matos F.J.A., and Viana G.S.B. Estudo farmacológico comparativo de Mikania glomerata Spreng (guaco) Justicia pectoralis Jacq (anador) e Torresea cearensis Fr. All (cumarú). Revista Brasileira de Farmácia 74 (1993) 12-15
21. Lucas V. Estudo farmacognóstico do guaco Mikania glomerata Sprengel. Revista da Flora Medicinal 9 (1942) 101-132
22. Magalhães P.M. Agrotecnologia Para el Cultivo de Guaco o Guaco Oloroso (2000), CAB/CYTED, Santafé de Bogotá
23. Oliveira F., Akisue G., Akisue M.K., and Jorge L.I.F. Morfodiagnose das folhas e das partes reprodutivas de Mikania laevigata Schultz Bip ex Baker. Revista Brasileira de Farmacognosia 1 (1986) 20-34
24. Oliveira F., Alvarenga M.A., Akisue G., and Akisue M.K. Isolamento e identificação de componentes químicos de Mikania glomerata Spreng e de Mikania laevigata Schultz Bip ex Baker 2 (1984), Revista da Faculdade de Farmácia e Bioquímica da Universidade de São Paulo pp. 169-183
25. Organization for Economic Co-Operation and Development-OECD, 1998. Guideline 408: subchronic oral toxicity-Rodent: 90 days. Paris.
26. Ritter M.R., and Waechter J.L. Biogeografia do gênero Mikania Willd. (Asteraceae) no Rio Grande do Sul Brasil. Acta Botanica Brasilica 3 (2004) 643-652
27. Santos S.C., Pereira C.I., and Biavatti M.W. Doseamento da cumarina (1,2 benzopirona) no xarope de guaco (Mikania glomerata Spreng) produzido pelo laboratório de fitoterápicos da UNIVALE. XV Simpósio de Plantas Medicinais do Brasil (1998), UNIFESP, Águas de Lindóia
28. Sipahi E.Y., Turker R.K., and Ercan Z.S. Nitric oxide and prostanoid-dependent relaxation induced by angiotensin II in the isolated precontracted mouse tracheal muscle and the role of potassium channels. Pharmacological Research 42 (2000) 69-74
29. + channel. Experimental Physiology 84 (1999) 835-846
30. Suyenaga E.S., Reche E., Farias F.M., Schapoval E.E., Chaves C.G., and Henriques A.T. Antiinflammatory investigation of some species of Mikania. Phytotherapy Research 16 (2002) 519-523
31. World Health Organization-WHO, 1993. Research guidelines for evaluating the safety and efficacy of herbal medicines. Regional Office for the Western Pacific.
32. Yatsuda R., Rosalen P.L., Cury J.A., Murata R.M., Rehder V.L., Melo L.V., and Koo H. Effects of Mikania genus plants on growth and cell adherence of mutans streptococci. Journal of Ethnopharmacology 97 (2005) 183-189