Ibuprofen use during extreme exercise: Effects on oxidative stress and PGE2

Medicine and Science in Sports and Exercise

Volumn 39, Issue 7, 2007, Pages 1075-1079

  McAnulty, Steven R ^a   Owens, John T ^a   McAnulty, Lisa S ^a   Nieman, David C ^a   Morrow, Jason D ^b   Dumke, Charles L ^a   Milne, Ginger L ^b  

^a APPALACHIAN STATE UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Nitrite; NSAID; Prostaglandins; Urate

Indexed keywords

IBUPROFEN; ISOPROSTANE DERIVATIVE; NITRITE; PROSTAGLANDIN E2; URATE;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG USE; ENDURANCE; EXERCISE; FEMALE; HUMAN; MALE; MARATHON RUNNER; METABOLITE; OXIDATIVE STRESS; RUNNING; SIDE EFFECT; SPORT; UNITED STATES; URIC ACID BLOOD LEVEL; URINALYSIS;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALIFORNIA; EXERTION; FEMALE; HUMANS; IBUPROFEN; MALE; MIDDLE AGED; OXIDATIVE STRESS; PROSTAGLANDINS E; RUNNING;

EID: 34347325205     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/mss.0b13e31804a8611     Document Type: Article

References (26)

1. ASHTON, T., I. S. YOUNG, G. W. DAVISON, et al. Exercise-induced endotoxemia: the effect of ascorbic acid supplementation. Free Radic. Biol. Med. 35:284-291, 2003.
2. BACHI, A., R. BRAMBILLA, R. FANELLI, R. BIANCHI, E. ZUCCATO, and C. CHIABRANDO. Reduction of urinary 8-epi-prostaglandin F2 alpha during cyclo-oxygenase inhibition in rats but not in man. Br. J. Pharmacol. 121:1770-1774, 1997.
3. BASU, S., and M. ERIKSSON. Oxidative injury and survival during endotoxemia. FEBS Lett. 438:159-160, 1998.
4. BOELSTERLI, U. A. Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide. Drug Saf. 25:633-648, 2002.
5. BOELSTERLI, U. A. Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. Toxicol. Appl. Pharmacol. 192: 307-322, 2003.
6. BOSENBERG, A. T., J. G. BROCK-UTNE, S. L. GAFFIN, M. T. WELLS, and G. T. BLAKE. Strenuous exercise causes systemic endotoxemia. J. Appl. Physiol 65:106-108, 1988.
7. CANTONI, L., R. VALAPERTA, X. PONSODA, et al. Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity. J. Hepatol. 38:776-783, 2003.
8. CHENG, H. F., and R. C. HARRIS. Cyclooxygenases, the kidney, and hypertension. Hypertension 43:525-530, 2004.
9. DILL, D. B., and D. L. COSTILL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J. Appl. Physiol. 37:247-248, 1974.
10. FACKOVCOVA, D., V. KRISTOVA, and M. KRISKA. Renal damage induced by the treatment with non-opioid analgesics-theoretical assumption or clinical significance. Bratisl. Lek. Listy 101:417-422, 2000.
11. FARQUHAR, W. B., and W. L. KENNEY. Age and renal prostaglandin inhibition during exercise and heat stress. J. Appl. Physiol. 86: 1936-1943, 1999.
12. FUKUNAGA, M., N. MAKITA, L. J. ROBERTS, J. D. MORROW, K. TAKAHASHI, and K. F. BADR. Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. Am. J. Physiol. 264:C1619-C1624, 1993.
13. HICKEY, E. J., R. R. RAJE, V. E. REID, S. M. GROSS, and S. D. RAY. Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radic. Biol. Med. 31:139-152, 2001.
14. IRVING, R. A., T. D. NOAKES, S. C. BURGER, K. H. MYBURGH, D. QUERIDO, and S. R. VAN ZYL. Plasma volume and renal function during and after ultramarathon running. Med. Sci. Sports Exerc. 22:581-587, 1990.
15. MANN, J. F., M. GOERIG, K. BRUNE, and F. C. LUFT. Ibuprofen as an over-the-counter drug: is there a risk for renal injury? Clin. Nephrol. 39:1-6, 1993.
16. MCANULTY, S. R., L. S. MCANULTY, D. C. NIEMAN, et al. Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise. J. Nutr. Biochem. 16:530-537, 2005.
17. MCANULTY, S. R., L. S. MCANULTY, D. C. NIEMAN, et al. Influence of carbohydrate ingestion on oxidative stress and plasma antioxidant potential following a 3 h run. Free Radic. Res. 37: 835-840, 2003.
18. MORROW, J. D., and L. J. ROBERTS. The isoprostanes: unique bioactive products of lipid peroxidation. Prog. Lipid Res. 36:1-21, 1997.
19. MORROW, J. D., and L. J. ROBERTS. Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol. 300:3-12, 1999.
20. MURPHEY, L. J., M. K. WILLIAMS, S. C. SANCHEZ, et al. Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase- specific PGE2 synthesis in healthy humans and those with lung cancer. Anal. Biochem. 334: 266-275, 2004.
21. NIEMAN, D. C., C. I. DUMKE, D. A. HENSON, et al. Immune and oxidative changes during and following the Western States Endurance Run. Int. J. Sports Med. 24:541-547, 2003.
22. NIEMAN, D. C., C. L. DUMKE, D. A. HENSON, S. R. MCANULTY, S. J. GROSS, and R. H. LIND. Muscle damage is linked to cytokine changes following a 160-km race. Brain Behav. Immun. 19:398-403, 2005.
23. PANNALA, A. S., A. R. MANI, J. P. SPENCER, et al. The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic. Biol. Med. 34:576-584, 2003.
24. RYAN, A. J., R. T. CHANG, and C. V. GISOLFI. Gastrointestinal permeability following aspirin intake and prolonged running. Med. Sci. Sports Exerc. 28:698-705, 1996.
25. VASSALLE, C., V. LUBRANO, A. L'ABBATE, and A. CLERICO. Determination of nitrite plus nitrate and malondialdehyde in human plasma: analytical performance and the effect of smoking and exercise. Clin. Chem. Lab Med. 40:802-809, 2002.
26. WARING, W. S., D. J. WEBB, and S. R. MAXWELL. Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. J. Cardiovasc. Pharmacol. 38:365-371, 2001.