PKCζ protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production

Biochemical Journal

Volumn 405, Issue 1, 2007, Pages 77-83

  Charruyer, Alexandra ^a,b   Jean, Christine ^a,b   Colomba, Audrey ^a,b   Jaffrézou, Jean Pierre ^a,b   Quillet Mary, Anne ^a,b   Laurent, Guy ^a,c   Bezombes, Christine ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c CHU PURPAN   (France)

Author keywords

Acid sphingomyelinase; Antioxidant defence; Protein kinase C (PKC ); Raft; Thioredoxin peroxidase; UV C

Indexed keywords

AMIDES; CARCINOGENS; ENZYME ACTIVITY; GENE EXPRESSION; HYDROLYSIS;

ACID SPHINGOMYELINASE; ANTIOXIDANT DEFENCE; PROTEIN KINASE C; RAFT; RAFT MICRODOMAINS; THIOREDOXIN PEROXIDASE; UV-INDUCED CARCINOGENESIS;

CELL DEATH;

CERAMIDE; PROTEIN KINASE C ZETA; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; THIOREDOXIN; THIOREDOXIN PEROXIDASE; THIOREDOXIN REDUCTASE; HYDROGEN PEROXIDE; OXIDIZING AGENT; PROTEIN KINASE C;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PHOTOTHERAPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RADIATION CARCINOGENESIS; TREATMENT FAILURE; ULTRAVIOLET C RADIATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL MEMBRANE; DRUG ANTAGONISM; GENETICS; METABOLISM; PHYSIOLOGY; RADIATION EXPOSURE; RAT; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CELL LINE; CERAMIDES; HUMANS; HYDROGEN PEROXIDE; MEMBRANE MICRODOMAINS; OXIDANTS; PROTEIN KINASE C; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; THIOREDOXIN; ULTRAVIOLET RAYS;

EID: 34347263714     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20061528     Document Type: Article

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