Apoptosis of HL-60 cells induced by dihydroartemisinin

Chinese Journal of Pharmacology and Toxicology

Volumn 21, Issue 3, 2007, Pages 217-222

  Li, Ao ^a   Zhou, Hui Jun ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Dihydroartemisinin; HL 60 cells

Indexed keywords

ACRIDINE ORANGE; ANTILEUKEMIC AGENT; CASPASE 3; DIHYDROARTEMISININ; ETHIDIUM BROMIDE; PROTEIN BAX; PROTEIN BCL 2; TRYPAN BLUE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; ELECTROPHORESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN FAMILY; STAINING; WESTERN BLOTTING;

EID: 34347241281     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Chen HH, Zhou HJ, Wang WQ, Wu GD. Antimalarial dihydroartemisinin also inhibits angiogenesis[J]. Cancer Chemother Pharmacol, 2004, 53(5): 423-432.
2. Chen WQ, Qi HW, Wu CG, Cui Y, Liu B, Li Y, et al. Effect of dihydroartemisinin on proliferation of human lung adenocarcinoma cell line A549[J]. Chin J Lung Cancer, 2005, 8(2): 85-88.
3. Disbrow GL, Baege AC, Kierpiec KA, Yuan H, Centeno JA, Thibodeaux CA, et al. Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo[J]. Cancer Res, 2005, 65(23): 10854-10861.
4. Lee J, Zhou HJ, Wu XH. Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells[J]. Cancer Chemother Pharmacol, 2006, 57(2): 213-220.
5. Chen HH, Zhou HJ, Fang X. Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro[J]. Pharmacol Res, 2003, 48(3): 231-236.
6. Wu GD, Zhou HJ. Apoptosis of human umbilical vein endothelial cells induced by artesunate[J]. Chin J Pharmacol Toxicol, 2004, 18(4): 294-299.
7. Wu XH, Zhou HJ, Lee J. Dihydroartemisinin inhibits angiogenesis induced by multiple myeloma RPMI8226 cells under hypoxic conditions via downregulation of vascular endothelial growth factor expression and suppression of vascular endothelial growth factor secretion[J]. Anticancer Drugs, 2006, 17(7): 839-848.
8. Gottlieb RA. Mitochondria: execution central[J]. FEBS Lett, 2000, 482(1-2): 6-12.
9. Evan G, Littlewood T. A matter of life and cell death[J]. Science, 1998, 281(5381): 1317-1322.
10. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked[J]. Science, 1997, 275(5303): 1129-1132.
11. Schwarz CS, Evert BO, Seyfried J, Schaupp M, Kunz WS, Vielhaber S, et al. Overexpression of bcl-2 results in reduction of cytochrome c content and inhibition of complex I activity[J]. Biochem Biophys Res Commun, 2001, 280(4): 1021-1027.
12. Katoh O, Takahashi T, Oguri T, Kuramoto K, Mihara K, Kobayashi M, et al. Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor[J]. Cancer Res, 1998, 58(23): 5565-5569.
13. Dias S, Shmelkov SV, Lam G, Rafii S. VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition[J]. Blood, 2002, 99(7): 2532-2540.