Apoptosis of human umbilical vein endothelial cells induced by artesunate

Chinese Journal of Pharmacology and Toxicology

Volumn 18, Issue 4, 2004, Pages 294-299

  Wu, Guo Dong ^a   Zhou, Hui Jun ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Artesunate; Calcium, cytosolic; Cells, cultured; Endothelium, vascular

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACRIDINE ORANGE; ARTESUNATE; CALCIUM; ETHIDIUM BROMIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA ELECTROPHORESIS; DRUG EFFECT; ELECTROPHORESIS; ENDOTHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; UMBILICAL VEIN; VITAL STAIN;

ARTESUNATE;

EID: 4444245594     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Li Y, Shan F, Wu JM, Wu GS, Ding J, Xiao D, et al. Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle[J]. Bioorg Med Chem Lett, 2001, 11(1):5-8.
2. Sadava D, Phillips T, Lin C, Kane SE. Transferrin overcomes drug resistance to artemisinin in human small-cell lung carcinoma cells[J]. Cancer Lett, 2002, 179(2):151-156.
3. Wang Q, Wu LM, Zhao Y, Zhang XL, Wang NP. The anticancer effect of artesunate and its mechanism[J]. Acta Pharma Sin, 2002, 37(6):477-478.
4. Li Y, Li Y, Xu GL. Clinical studies on the induction of apoptosis by artesunate on human leukaemic K562 cells[J]. Shandong Med J, 2003, 43(16):23-24.
5. Chen HH, Zhou HJ, Fang X. Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro[J]. Pharmacol Res, 2003, 48(3):231-236.
6. Wang WQ, Zhou HJ, Chen HH, Wu GD. Inhibitory effect of artesunate in angiogenesis[J]. Chin J Pharmacol Toxicol, 2004, 18(1):32-36.
7. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria[J]. J Clin Invest, 1973, 52(11):2745-2756.
8. Bachetti T, Morbidelli L. Endothelial cells in culture: a model for studying vascular functions[J]. Pharmacol Res, 2000, 42(1):9-19.
9. Gorman A. Morphological assessment of apoptosis[A]. In: Cotter TG, Martin SJ, ed. Techniques in apoptosis. A use's guide[M]. London: Portland Press Ltd., 1996.7-9.
10. 2+ indicators with greatly improved fluorescence properties[J]. J Biol Chem, 1985, 260(6):3440-3450.
11. Whyte MK, Hardwick SJ, Meagher LC, Savill JS, Haslett C. Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro[J]. J Clin Invest, 1993, 92(1):446-455.
12. Folkman J, Klagsbrun M. Angiogenic factors[J]. Science, 1987, 235(4787):442-447.
13. Folkman J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis[J]. N Engl J Med, 1995, 333(26):1757-1763.