Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV

Journal of Neuroimmunology

Volumn 187, Issue 1-2, 2007, Pages 147-155

  Brudek, Tomasz ^a   Lühdorf, Pernille ^a   Christensen, Tove ^a   Hansen, Hans Jacob ^a   Møller Larsen, Anné ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Herpesviruses; Human endogenous retrovirus; Multiple sclerosis; Reverse transcriptase

Indexed keywords

HERPES SIMPLEX VIRUS 1 ANTIGEN; HUMAN HERPES VIRUS 1 ANTIGEN; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VARICELLA ZOSTER VIRUS ANTIGEN; VIRUS ANTIGEN;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HERPES VIRUS; HUMAN; MALE; MULTIPLE SCLEROSIS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS ACTIVATION;

ADULT; ANTIGENS, VIRAL; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENDOGENOUS RETROVIRUSES; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 1, HUMAN; HERPESVIRUS 3, HUMAN; HERPESVIRUS 6, HUMAN; HUMANS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA-DIRECTED DNA POLYMERASE; TIME FACTORS; VIRUS ACTIVATION;

EID: 34347240368     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2007.04.003     Document Type: Article

References (44)

1. Alshubaili A.F., Alramzy K., Ayyad Y.M., and Gerish Y. Epidemiology of multiple sclerosis in kuwait: new trends in incidence and prevalence. Eur. Neurol. 53 (2005) 125-131
2. Alvarez-Lafuente R., de, L.H. V., Bartolome M., Picazo J.J., and Arroyo R. Relapsing-remitting multiple sclerosis and human herpesvirus 6 active infection. Arch. Neurol. 61 (2004) 1523-1527
3. Antony J.M., van M.G., Opii W., et al. Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nat. Neurosci. 7 (2004) 1088-1095
4. Brudek T., Christensen T., Hansen H.J., Bobecka J., and Moller-Larsen A. Simultaneous presence of endogenous retrovirus and herpes virus antigens has profound effect on cell-mediated immune responses: implications for multiple sclerosis. AIDS Res. Hum. Retrovir. 20 (2004) 415-423
5. Chapenko S., Millers A., Nora Z., Logina I., Kukaine R., and Murovska M. Correlation between HHV-6 reactivation and multiple sclerosis disease activity. J. Med. Virol. 69 (2003) 111-117
6. Christensen T. Association of human endogenous retroviruses with multiple sclerosis and possible interactions with herpes viruses. Rev. Med. Virol. 15 (2005) 179-211
7. Christensen T., Jensen A.W., Munch M., Haahr S., Sorensen P.D., Riemann H., Hansen H.J., and Moller-Larsen A. Characterization of retroviruses from patients with multiple sclerosis. Acta. Neurol. Scand. Supp 69 (1997) 49-58
8. Christensen T., Dissing S.P., Riemann H., Hansen H.J., and Moller-Larsen A. Expression of sequence variants of endogenous retrovirus RGH in particle form in multiple sclerosis. Lancet 352 (1998) 1033
9. Christensen T., Pedersen L., Sorensen P.D., and Moller-Larsen A. A transmissible human endogenous retrovirus. AIDS Res. Hum. Retrovir. 18 (2002) 861-866
10. Christensen T., Sorensen P.D., Hansen H.J., and Moller-Larsen A. Antibodies against a human endogenous retrovirus and the preponderance of env splice variants in multiple sclerosis patients. Mult. Scler. 9 (2003) 6-15
11. Christensen T., Petersen T., Thiel S., Brudek T., Ellermann-Eriksen S., and Moller-Larsen A. Gene-environment interactions in multiple sclerosis: innate and adaptive immune responses to human endogenous retrovirus and herpesvirus antigens and the lectin complement activation pathway. Journal of Neuroimmunology 183 (2007) 175-188
12. Clark D. Human herpesvirus type 6 and multiple sclerosis. Herpes 11 Suppl 2 (2004) 112A-119A
13. Csoma E., Bacsi A., Liu X., et al. Human herpesvirus 6 variant a infects human term syncytiotrophoblasts in vitro and induce s replication of human immunodeficiency virus type 1 in dually infected cells. J. Med. Virol. 67 (2002) 67-87
14. Ferrante P., Mancuso R., Pagani E., Guerini F.R., Calvo M.G., Saresella M., Speciale L., and Caputo D. Molecular evidences for a role of HSV-1 in multiple sclerosis clinical acute attack. J. Neurovirol. 6 Suppl 2 (2000) S109-S114
15. Finzi D., Plaeger S.F., and Dieffenbach C.W. Defective virus drives human immunodeficiency virus infection, persistence, and pathogenesis. Clin. Vaccine Immunol. 13 (2006) 715-721
16. Fotheringham J., and Jacobson S. Human herpesvirus 6 and multiple sclerosis: potential mechanisms for virus-induced disease 3. Herpes 12 (2005) 4-9
17. Garson J.A., Tuke P.W., Giraud P., Paranhos-Baccala G., and Perron H. Detection of virion-associated MSRV-RNA in serum of patients with multiple sclerosis. Lancet 351 (1998) 33
18. Jolivet-Reynaud C., Perron H., Ferrante P., Becquart L., Dalbon P., and Mandrand B. Specificities of multiple sclerosis cerebrospinal fluid and serum antibodies against mimotopes. Clin. Immunol. 93 (1999) 283-293
19. Kim J.M., Hong Y., Jeang K.T., and Kim S. Transactivation activity of the human cytomegalovirus IE2 protein occurs at steps subsequent to TATA box-binding protein recruitment. J. Gen. Virol. 81 (2000) 37-46
20. Komurian-Pradel F., Paranhos-Baccala G., Bedin F., et al. Molecular cloning and characterization of MSRV-related sequences associated with retrovirus-like particles. Virology 260 (1999) 1-9
21. Kwun H.J., Han H.J., Lee W.J., Kim H.S., and Jang K.L. Transactivation of the human endogenous retrovirus K long terminal repeat by herpes simplex virus type 1 immediate early protein 0. Virus Res. 86 (2002) 93-100
22. Lee W.J., Kwun H.J., Kim H.S., and Jang K.L. Activation of the human endogenous retrovirus W long terminal repeat by herpes simplex virus type 1 immediate early protein 1. Mol. Cells 15 (2003) 75-80
23. Mancuso R., Delbue S., Borghi E., Pagani E., Calvo M.G., Caputo D., Granieri E., and Ferrante P. Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis1. J. Med. Virol. 79 (2007) 192-199
24. Mangeney M., de Parseval N., Thomas G., and Heidmann T. The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties. J. Gen. Virol. 82 (2001) 2515-2518
25. Moriuchi M., and Moriuchi H. Increased susceptibility to HIV-1 of peripheral blood lymphocytes in acute infection with Epstein-Barr virus. J. Med. Virol. 71 (2003) 343-346
26. Moriuchi M., Moriuchi H., Williams R., and Straus S.E. Herpes simplex virus infection induces replication of human immunodeficiency virus type 1. Virology 278 (2000) 534-540
27. Munch M., Moller-Larsen A., Christensen T., Morling N., Hansen H.J., and Haahr S. B-lymphoblastoid cell lines from multiple sclerosis patients and a healthy control producing a putative new human retrovirus and Epstein-Barr virus. Mult. Scler. 1 (1995) 78-81
28. Nellaker C., Yao Y., Jones-Brando L., Mallet F., Yolken R.H., and Karlsson H. Transactivation of elements in the human endogenous retrovirus W family by viral infection. Retrovirology 3 (2006) 44
29. Nicoletti A., Patti F., Lo F.S., Sorbello V., Reggio E., Maimone D., Zappia M., and Reggio A. Possible increasing risk of multiple sclerosis in Catania, Sicily. Neurology 65 (2005) 1259-1263
30. Ordonez G., Pineda B., Garcia-Navarrete R., and Sotelo J. Brief presence of varicella-zoster vral DNA in mononuclear cells during relapses of multiple sclerosis. Arch. Neurol. 61 (2004) 529-532
31. Palu G., Benetti L., and Calistri A. Molecular basis of the interactions between herpes simplex viruses and HIV-1. Herpes 8 (2001) 50-55
32. Perl A. Role of endogenous retroviruses in autoimmune diseases. Rheum. Dis. Clin. North Am. 29 (2003) 123-143 (vii)
33. Perron H., Suh M., Lalande B., Gratacap B., Laurent A., Stoebner P., and Seigneurin J.M. Herpes simplex virus ICP0 and ICP4 immediate early proteins strongly enhance expression of a retrovirus harboured by a leptomeningeal cell line from a patient with multiple sclerosis. J. Gen. Virol. 74 Pt 1 (1993) 65-72
34. Perron H., Garson J.A., Bedin F., et al. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 7583-7588
35. Perron H., Jouvin-Marche E., Michel M., et al. Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16T-lymphocyte activation. Virology 287 (2001) 321-332
36. Pyra H., Boni J., and Schupbach J. Ultrasensitive retrovirus detection by a reverse transcriptase assay based on product enhancement. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 1544-1548
37. Rolland A., Jouvin-Marche E., Saresella M., Ferrante P., Cavaretta R., Creange A., Marche P., and Perron H. Correlation between disease severity and in vitro cytokine production mediated by MSRV (multiple sclerosis associated retroviral element) envelope protein in patients with multiple sclerosis. J. Neuroimmunol. 160 (2005) 195-203
38. Ruprecht K., Obojes K., Wengel V., Gronen F., Kim K.S., Perron H., Schneider-Schaulies J., and Rieckmann P. Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: implications for multiple sclerosis. J. Neurovirol. 12 (2006) 65-71
39. Serra C., Sotgiu S., Mameli G., Pugliatti M., Rosati G., and Dolei A. Multiple sclerosis and multiple sclerosis-associated retrovirus in Sardinia. Neurol. Sci. 22 (2001) 171-173
40. Serra C., Mameli G., Arru G., Sotgiu S., Rosati G., and Dolei A. In vitro modulation of the multiple sclerosis (MS)-associated retrovirus by cytokines: implications for MS pathogenesis. J. Neurovirol. 9 (2003) 637-643
41. Simmons A. Herpesvirus and multiple sclerosis. Herpes 8 (2001) 60-63
42. Soldan S.S., Leist T.P., Juhng K.N., McFarland H.F., and Jacobson S. Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients. Ann. Neurol. 47 (2000) 306-313
43. Sutkowski N., Conrad B., Thorley-Lawson D.A., and Huber B.T. Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen124. Immunity 15 (2001) 579-589
44. Wallin M.T., Page W.F., and Kurtzke J.F. Multiple sclerosis in US veterans of the Vietnam era and later military service: race, sex, and geography. Ann. Neurol. 55 (2004) 65-71