The structure of the macrophage signal regulatory protein α (SIRPα) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors

Journal of Biological Chemistry

Volumn 282, Issue 19, 2007, Pages 14567-14575

  Hatherley, Deborah ^a   Harlos, Karl ^b   Dunlop, D Cameron ^b   Stuart, David I ^b   Barclay, A Neil ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; MACROPHAGE SIGNAL REGULATORY PROTEIN; MYELOID CELLS; X-RAY STRUCTURE;

ANTIGENS; BINDING SITES; CELL MEMBRANES; MUTAGENESIS; X RAY ANALYSIS;

PROTEINS;

CD47 ANTIGEN; IMMUNOGLOBULIN; MEMBRANE RECEPTOR; SIGNAL REGULATORY PROTEIN ALPHA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; DIFFERENTIATION ANTIGEN; IMMUNOGLOBULIN RECEPTOR; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; SIRPA PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; GENE EXPRESSION; GENE STRUCTURE; LIGAND BINDING; MACROPHAGE; MEMORY; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN FOLDING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIGENS, CD47; ANTIGENS, DIFFERENTIATION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MACROPHAGES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN FOLDING; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, IMMUNOLOGIC; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 34347235840     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611511200     Document Type: Article

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