Time course of the defective α-cell response to hypoglycemia in diabetic BB rats

Metabolism: Clinical and Experimental

Volumn 45, Issue 11, 1996, Pages 1422-1426

  Jacob, Ralph J ^a   Dziura, James ^a   Morgen, Jennifer P ^a   Shulman, Gerald I ^a   Sherwin, Robert S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON;

ADRENALIN RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DIABETES CONTROL; GLUCAGON BLOOD LEVEL; HORMONE RESPONSE; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INTESTINE ABSORPTION; NONHUMAN; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; RAT; TIME;

EID: 0029841692     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90125-0     Document Type: Article

References (24)

1. Diabetes Control and Complications Trial: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
2. Cryer PE, Fisher JN, Shamoon H: Hypoglycemia: A technical review. Diabetes Care 17:734-755, 1994
3. Gerich JE, Schneider V, Dippe SE, et al: Characterization of the glucagon response to hypoglycemia in man. J Clin Endocrinol Metab 38:77-82, 1974
4. Unger RH, Eisentraut AM, McCall MS, et al: Measurements of endogenous glucagon in plasma and the influence of blood glucose concentration upon its secretion. J Clin Invest 41:682-689, 1962
5. Weir GC, Knowlton SD, Martin DB: Glucagon secretion from the perfused rat pancreas: Studies with glucose and catecholamines. J Clin Invest 54:1403-1412, 1974
6. Gerich JE, Langlois M, Noacco C, et al: Lack of glucagon response to hypoglycemia in diabetes: Evidence for an intrinsic pancreatic alpha cell defect. Science 182:171-172, 1973
7. Bolli G, DeFeo P, Compagnucci P, et al: Abnormal glucose counterregulation in insulin-dependent diabetes mellitus: Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 32:134-141, 1983
8. Benson JW, Johnson DG, Palmer JP, et al: Glucagon and catecholamine secretion during hypoglycemia in normal and diabetic man. J Clin Endocrinol Metab 44:459-464, 1977
9. Santiago JV, Clarke WL, Shah SD, et al: Epinephrine, norepinephrine, glucagon and growth hormone release in association with physiological decrements in the plasma glucose concentration in normal and diabetic man. J Clin Endocrinol Metab 51:877-883, 1980
10. Dagogo-Jack SE, Craft S, Cryer PE: Hypoglycemia-associated autonomic failure in insulin dependent diabetes mellitus. J Clin Invest 91:819-828, 1993
11. Hirsch BR, Shamoon H: Defective epinephrine and growth hormone responses in type I diabetes are stimulus specific. Diabetes 36:20-26, 1987
12. Amiel SA, Pottinger RC, Archibald HR, et al: Effect of antecedent glucose control on cerebral function during hypoglycemia. Diabetes Care 14:109-118, 1991
13. Lingenfelser T, Renn W, Sommerwerck U, et al: Compromised hormonal counterregulation, symptom awareness, and neurophysiological function after recurrent short-term episodes of insulin-induced hypoglycemia in IDDM patients. Diabetes 42:610-618, 1993
14. Ziegler D, Hubinger A, Muhlen H, et al: Effects of previous glycaemic control on the onset and magnitude of cognitive dysfunction during hypoglycaemia in type 1 (insulin-dependent) diabetic patients. Diabetologia 35:828-834, 1992
15. Bolli G, Calabrese G, DeFeo P, et al: Lack of glucagon response in glucose counter-regulation in type 1 (insulin-dependent) diabetics: Absence of recovery after prolonged optimal insulin therapy. Diabetologia 22:100-105, 1982
16. Unger RH, Aguilar-Parada E, Muller WA, et al: Studies of pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest 49:837-848, 1970
17. Wise JK, Hendler R, Felig P: Evaluation of alpha-cell function by infusion of alanine in normal, diabetic and obese subjects. N Engl J Med 288:487-490, 1973
18. Fukuda M, Tanaka A, Tahara Y, et al: Correlation between minimal secretory capacity of pancreatic B-cells and stability of diabetic control. Diabetes 37:81-88, 1988
19. Unger RH, Madison LL, Muller WA: Abnormal alpha cell function in diabetics: Response to insulin. Diabetes 21:301-307, 1972
20. Powell AM, Sherwin RS, Shulman GI: Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats: Reversibility and stimulus specificity of the deficits. J Clin Invest 92:2667-2674, 1993
21. Jacob R, Barrett E, Plewe G, et al: Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. J Clin Invest 83:1717-1723, 1989
22. Raskin P, Fujita Y, Unger RH: Effect of insulin-glucose infusions on plasma glucagon levels in fasting diabetics and non-diabetics. J Clin Invest 56:1132-1138, 1975
23. Starke A, Imamura T, Unger RH: Relationship of glucagon suppression by insulin and somatostatin to the ambient glucose concentration. J Clin Invest 79:20-24, 1987
24. Borg WP, Sherwin RS, During MS, et al: Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 44:180-184, 1995