Regulation of α-cell function by the β-cell in isolated human and rat islets deprived of glucose: The "switch-off" hypothesis

Diabetes

Volumn 53, Issue 6, 2004, Pages 1488-1495

  Hope, Kristine M ^a   Tran, Phuong Oanh T ^a   Zhou, Huarong ^a   Oseid, Elizabeth ^a   Leroy, Eric ^a   Robertson, R Paul ^a,b,c  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; METHYLXANTHINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLUCAGON RELEASE; HORMONAL REGULATION; HUMAN; HUMAN CELL; HYPOGLYCEMIA; INSULIN INFUSION; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DRUG ADMINISTRATION SCHEDULE; GLUCAGON; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; RATS;

EID: 2542622239     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.6.1488     Document Type: Article

References (38)

1. Taborsky GJ Jr, Ahren B, Havel PJ: Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired α-cell responses in type 1 diabetes. Diabetes 47:995-1005, 1998
2. Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH: Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 182:171-173, 1973
3. Fukuda M, Tanaka A, Tahara Y, Ikegami H, Yamamoto Y, Kumahara Y, Shima K: Correlation between minimal secretory capacity of pancreatic β-cells and stability of diabetic control. Diabetes 37:81-88, 1988
4. Diamond MP, Hallarman L, Starick-Zych K, Jones TW, Connolly-Howard M, Tamborlane WV, Sherwin RS: Suppression of counterregulatory hormone response to hypoglycemia by insulin per se. J Clin Endocrinol Metab 72:1388-1390, 1991
5. Liu D, Moberg E, Kollind M, Lins PE, Adamson U: A high concentration of circulating insulin suppresses the glucagon response to hypoglycemia in normal man. J Clin Endocrinol Metab 73:1123-1128, 1991
6. Rizza RA, Cryer PE, Gerich JE: Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. J Clin Invest 64:62-71, 1979
7. Liu DT, Adamson UC, Lins PE, Kollind ME, Moberg EA, Andreasson K: Inhibitory effect of circulating insulin on glucagon secretion during hypoglycemia in type 1 diabetic patients. Diabetes Care 15:59-65, 1992
8. Mellman MJ, Davis MR, Shamoon H: Effect of physiological hyperinsulinemia on counterregulatory hormone responses during hypoglycemia in humans. J Clin Endocrinol Metab 75:1293-1297, 1992
9. Davis MR, Mellman M, Shamoon H: Physiologic hyperinsulinemia enhances counterregulatory hormone responses to hypoglycemia in IDDM. J Clin Endocrinol Metab 76:1383-1385, 1993
10. Davis SN, Goldstein RE, Jacobs J, Price L, Wolfe R, Cherrington AD: The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. Diabetes 42:263-272, 1993
11. Davis SN, Goldstein RE, Price L, Jacobs J, Cherrington AD: The effects of insulin on the counterregulatory response to equivalent hypoglycemia in patients with insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 77:1300-1307, 1993
12. Peacey SR, Rostami-Hodjegan A, George E, Tucker GT, Heller SR: The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans. J Clin Endocrinol Metab 82:1458-1461, 1997
13. Landstedt-Hallin L, Adamson U, Lins PE: Oral glibenclamide suppresses glucagon secretion during insulin-induced hypoglycemia in patients with type 2 diabetes. J Clin Endocrinol Metab 84:3140-3145, 1999
14. Segel SA, Paramore DS, Cryer PE: Hypoglycemia-associated autonomic failure in advanced type 2 diabetes. Diabetes 51:724-733, 2002
15. Banarer S, McGregor VP, Cryer PE: Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. Diabetes 51:958-965, 2002
16. Zhou H, Tran POT, Yang S, Zhang T, LeRoy E, Oseid E, Robertson RP: Regulation of α-cell function by the β-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesis. Diabetes 53:1482-1487, 2004
17. Lacy PE, Kostianovsky M: Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35-39, 1969
18. Morgan CR, Lazarow A: Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic, and diabetic rats. Diabetes 12:115-126, 1963
19. Harris, V Faloona GR, Unger RH: Glucagon. In Methods of Hormone Radioimmunoassay. Jaffe BM, Behrman HR, Eds. New York, Academic Press, 1979, p. 643
20. Weir GC, Knowlton SD, Atkins RF, McKennan KX, Martin DB: Glucagon secretion from the perfused pancreas of streptozotocin-treated rats. Diabetes 25:275-282, 1976
21. Stagner JI, Samols E: Retrograde perfusion as a model for testing the relative effects of glucose versus insulin on the A cell. J Clin Invest 77:1034-1037, 1986
22. Maruyama H, Hisatomi A, Orci L, Grodsky GM, Unger RH: Insulin within islets is a physiologic glucagon release inhibitor. J Clin Invest 74:2296-2299, 1984
23. Asplin CM, Paquette TL, Palmer JP: In vivo inhibition of glucagon secretion by paracrine beta cell activity in man. J Clin Invest 68:314-318, 1981
24. Gorus FK, Malaisse WJ, Pipeleers DG: Differences in glucose handling by pancreatic A- and B-cells. J Biol Chem 259:1196-1200, 1984
25. Van Schravendijk CF, Foriers A, Hooghe-Peters EL, Rogiers V, De Meyts P, Sodoyez JC, Pipeleers DG: Pancreatic hormone receptors on islet cells. Endocrinology 117:841-848, 1985
26. Starks A, Imamura T, Unger RH: Relationship of glucagon suppression by insulin and somatostatin to the ambient glucose concentration. J Clin Invest 79:20-24, 1987
27. Shi ZQ, Rastogi KS, Lekas M, Efendic S, Drucker DJ, Vranic M: Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats. Endocrinology 137:3193-3199, 1996
28. Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F: The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells. Proc Natl Acad Sci U S A 93:7036-7041, 1996
29. Burcelin R, Thorens B: Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion. Diabetes 50:1282-1289, 2001
30. Gustavson SM, Nishizawa M, Farmer B, Neal D, Brissova M, Powers AC, Cherrington AD: A fall in portal vein insulin does not cause the alpha-cell response to mild, non-insulin-induced hypoglycemia in conscious dogs. Metabolism 52:1418-1425, 2003
31. McCrimmon RJ, Evans ML, Jacob RJ, Fan X, Zhu Y, Shulman GI, Sherwin RS: AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat. Am J Physiol Endocrinol Metab 283:E1076-E1083, 2002
32. Hisatomi A, Maruyama H, Orci L, Vasko M, Unger RH: Adrenergically mediated intrapancreatic control of the glucagon response to glucopenia in the isolated rat pancreas. J Clin Invest 75:420-426, 1985
33. Biggers DW, Myers SR, Neal D, Stinson R, Cooper NB, Jaspan JB, Williams PE, Cherrington AD, Frizzell RT: Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 38:7-16, 1989
34. Havel PJ, Veith RC, Dunning BE, Taborsky GJ Jr: Role for autonomic nervous system to increase pancreatic glucagon secretion during marked insulin-induced hypoglycemia in dogs. Diabetes 40:1107-1114, 1991
35. Davis SN, Colburn C, Dobbins R, Nadeau S, Neal D, Williams P, Cherrington AD: Evidence that the brain of the conscious dog is insulin sensitive. J Clin Invest 95:593-602, 1995
36. Havel PJ, Valverde C: Autonomic mediation of glucagon secretion during insulin-induced hypoglycemia in rhesus monkeys. Diabetes 45:960-966, 1996
37. Davis SN, Dunham B, Walmsley K, Shavers C, Neal D, Williams P, Cherrington AD: Brain of the conscious dog is sensitive to physiological changes in circulating insulin. Am J Physiol 272:E567-E575, 1997
38. Diem P, Redmon JB, Abid M, Moran A, Sutherland DE, Halter JB, Robertson RP: Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts. J Clin Invest 86:2008-2013, 1990