Arg16gly polymorphism of the beta2-adrenoceptor gene (ADRBeta2) as a susceptibility factor for nasal polyposis

American Journal of Rhinology

Volumn 21, Issue 3, 2007, Pages 378-382

  Bussu, Francesco ^a,b   Tiziano, Francesco Danilo ^a   Giorgio, Arianna ^a   Pinto, Anna Maria ^a   De Corso, Eugenio ^a   Angelozzi, Carla ^a   Brahe, Christina ^a   Paludetti, Gaetano ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

ADRB2 gene; Adrenoceptor; Genetic risk factor; Nasal polyposis; Susceptibility gene

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; GENOMIC DNA; ARGININE; GLYCINE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NOSE POLYP; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; AMINO ACID SUBSTITUTION; GENETIC PREDISPOSITION; GENETICS; HOMOZYGOTE; HYPERSENSITIVITY; MIDDLE AGED; REFERENCE VALUE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARGININE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLYCINE; HOMOZYGOTE; HUMANS; HYPERSENSITIVITY; MALE; MIDDLE AGED; NASAL POLYPS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, BETA-2; REFERENCE VALUES;

EID: 34250886363     PISSN: 10506586     EISSN: None     Source Type: Journal    
DOI: 10.2500/ajr.2007.21.3015     Document Type: Article

References (33)

1. Anand, VK. Epidemiology and economic impact of rhinosinusitis. Ann Otol Rhinol Laryngol Suppl 193:3-5, 2004.
2. Ray NF, Baraniuk JN, Thamer M, et al. Healthcare expenditures for sinusitis in 1996: Contributions of asthma, rhinitis, and other airway disorders. J Allergy Clin Immunol 103: 408-414, 1999.
3. Pawankar R. Nasal polyposis: An update: Editorial review. Curr Opin Allergy Clin Immunol 3:1-6, 2003.
4. Greisner WA III, and Settipane GA. Hereditary factor for nasal polyps. Allergy Asthma Proc 17:283-286, 1996.
5. Settipane GA. Epidemiology of nasal polyps. Allergy Asthma Proc 17:231-236, 1996.
6. Davare MA, Avdonin V, Hall DD, et al. A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. Science 293:98-101, 2001.
7. Luttrell LM, Ferguson SS, Daaka Y, et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283:655-661, 1999.
8. Maudsley S, Pierce KL, Zamah AM, et al. The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem 275:9572-9580, 2000.
9. Johnson M. The beta-adrenoceptor. Am J Respir Crit Care Med 158:S146-S153, 1998.
10. Freddolino PL, Kalani MY, Vaidehi N, et al. Predicted 3D structure for the human beta 2 adrenergic receptor and its binding site for agonists and antagonists. Proc Natl Acad Sci USA 101:2736-2741, 2004.
11. Kobilka BK, Dixon RA, Frielle T, et al. cDNA for the human beta 2-adrenergic receptor: A protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci USA 84: 46-50, 1987.
12. Yang-Feng TL, Xue FY, Zhong WW, et al. Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci USA 87:1516-1520, 1990.
13. Kobilka BK, Frielle T, Dohlman HG, et al. Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. J Biol Chem 262:7321-7327, 1987.
14. Strader CD, Sigal IS, and Dixon RA. Mapping the functional domains of the beta-adrenergic receptor. Am J Respir Cell Mol Biol 1:81-86, 1989.
15. Liggett SB. Pharmacogenetics of beta-1- and beta-2-adrenergic receptors. Pharmacology 61:167-173, 2000.
16. Drysdale CM, McGraw DW, Stack CB, et al. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 97:10483-10488, 2000.
17. Reihsaus E, Innis M, MacIntyre N, et al. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 8:334-339, 1993.
18. Green SA, Cole G, Jacinto M, et al. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem 268:23116-23121, 1993.
19. Green SA, Turki J, Innis M, et al. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 33:9414-9419, 1994.
20. Green SA, Turki J, Bejarano P, et al. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 13:25-33, 1995.
21. Silverman EK, Kwiatkowski DJ, Sylvia JS, et al. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol 112:870-876, 2003.
22. Taylor DR, and Kennedy MA. Genetic variation of the beta(2)-adrenoceptor: Its functional and clinical importance in bronchial asthma. Am J Pharmacogenomics 1:165-174, 2001.
23. Santillan AA, Camargo CA Jr, Ramirez-Rivera A, et al. Association between beta2-adrenoceptor polymorphisms and asthma diagnosis among Mexican adults. J Allergy Clin Immunol 112:1095-1100, 2003.
24. Turki J, Pak J, Green SA, et al. Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. J Clin Invest 95:1635-1641, 1995.
25. Martinez FD, Graves PE, Baldini M, et al. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 100:3184-3188, 1997.
26. Israel E, Drazen JM, Liggett SB, et al. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol 124:183-186, 2001.
27. Lund VJ, and Kennedy DW. Staging for rhinosinusitis. Otolaryngol Head Neck Surg 117:S35-S40, 1997.
28. Lund VJ, and Mackay IS. Staging in rhinosinusitus. Rhinology 31:183-184, 1993.
29. Johansson L, Akerlund A, Holmberg K, et al. Evaluation of methods for endoscopic staging of nasal polyposis. Acta Otolaryngol 120:72-76, 2000.
30. Wang X, Moylan B, Leopold DA, et al. Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population. JAMA 284:1814-1819, 2000.
31. Molnar-Gabor E, Endreffy E, and Rozsasi A. HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis. Laryngoscope 110:422-425, 2000.
32. Karjalainen J, Joki-Erkkila VP, Hulkkonen J, et al. The IL1A genotype is associated with nasal polyposis in asthmatic adults. Allergy 58:393-396, 2003.
33. van Megen YJ, Klaassen AB, Rodrigues de Miranda JF, et al. Alterations of adrenoceptors in the nasal mucosa of allergic patients in comparison with nonallergic individuals. J Allergy Clin Immunol 87:530-540, 1991.