Pulmonary vascular changes in piglets with increased pulmonary blood flow and pressure

Virchows Archiv

Volumn 450, Issue 6, 2007, Pages 643-652

  Gorenflo, Matthias ^a   Herpel, Esther ^a   Ullmann, Michael V ^a   Röhlig, Karoline ^a   Demirakca, Sueha ^b   Klimpel, Homa ^a   Hagl, Siegfried ^a   Gebhard, Martha Maria ^a   Schnabel, Philipp A ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Hypertension; Lung; Morphology; Pulmonary

Indexed keywords

ENDOTHELIN CONVERTING ENZYME; MESSENGER RNA; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANASTOMOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LUNG ARTERY; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; LUNG BLOOD VESSEL; NONHUMAN; PIGLET; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RNA ANALYSIS; SUBCLAVIAN ARTERY; SWINE; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; ASPARTIC ENDOPEPTIDASES; BLOOD PRESSURE; CYCLIC GMP; ENDOTHELIN-1; HYPERTENSION, PULMONARY; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LUNG; METALLOENDOPEPTIDASES; NITRATES; NITRITES; PULMONARY ARTERY; PULMONARY CIRCULATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAINING AND LABELING; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 34250853502     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-007-0414-7     Document Type: Article

References (35)

1. Black SM, Fineman JR, Steinhorn RH, Bristow J, Soifer SJ (1998) Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol 275:H1643-H1651
2. Black SM, BekkerJM, McMullan M, Parry AJ, Ovadia B, Reinhartz O, Lakshminrushimha S, Mata-Greenwood E, Steinhorn RH, Fineman JR (2002) Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatr Res 52:233-244
3. Carmeliet P, Moons L, Luttun A, Vincenti V, Compermolle V, De MM, Wu Y, Bono F, Devy L, Beck H, Scholz D, Acker T, DiPalma T, Dewerchin M, Noel A, Stalmans I, Barra A, Blacher S, Vandendrissche T, Ponten A, Eriksson U, Plate KH, Foidart JM, Schaper W, Charnock-Jones DS, Hicklin DJ, Herbert JM, Collen D, Persico MG (2001) Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 7:575-583
4. Celermajer DS, Cullen S, Deanfield JE (1993) Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation 87:440-446
5. Coers W, Temens W, Kempinga C, Klok PA, Moshage H (1998) Specificity of antibodies to nitric oxide synthase isoforms in human, guinea pig, rat, and mouse tissue. J Histochem Cytochem 46:1385-1391
6. Dschietzig T, Richter C, Bartsch C, Böhme C, Heinze D, Ott F, Zartnack F, Baumann G, Stangl K (2001) Flow induced pressure differentially regulates endothelin-1, urotensin II, adrenomedullin, and relaxin in pulmonary vascular endothelium. Biochem Biophys Res Commun 289:245-251
7. Everett AD, Le Cras TD, Xue TD, Johns RA (1998) eNOS expression is not altered in pulmonary vascular remodeling due to increased pulmonary blood flow. Am J Physiol 274:L1058-L1065
8. Fernandez-Mondéjar E, Hambraeus-Jonzon K, Ronéus A, Hedenstierna G (2003) Nitric oxide indreases dramatically in air exhaled from lung regions with occluded vessels. Acta Anaesthesiol Scand 47:312-318
9. Fike CD, Kaplowitz MR, Bousamra II M (2001) eNOS and prostanoid enzymes in lungs of newborn piglets with chronic aortopulmonary shunts. Am J Physiol 281:L475-L482
10. Geiger R, Berger RMF, Hess J, Bogers AJJC, Sharma HS, Mooi WJ (2000) Enhanced expression of vascular endothelial growth factor in pulmonary plexogenic due to congenital heart disease. J Pathol 191:202-207
11. Giaid A, Yanagisawa M, Langleben D, Michel, RP, Levy R, Shennib, H, Kimura S, Masaki T, Duguid WP, Stewart DJ (1993) Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 328:1732-1739
12. Giaid A (1998) Nitric oxide and endothelin-1 in pulmonary hypertension. Chest 114(Suppl 3):208S-212S
13. Gorenflo M, Vogel M, Hetzer R, Schmitz L, Berger F, Bein G, Alexi V, Lange PE (1996) Morphometric techniques in the evaluation of pulmonary vascular changes due to congenital heart disease. Pathol Res Pract 192:107-116
14. Gorenflo M, Ullmann M, Sebening Ch, Brockmeier K, Hagl S, Ulmer HE, Otto HF, Schnabel Ph A (2002) The index of pulmonary vascular disease in children with congenital heart disease: Relation to clinical and haemodynamic findings. Virchows Arch 441:264-270
15. Gorenflo M, Ullmann MV, Eitel K, Gross J, Fiehn W, Hagl S, Dreyhaupt J (2005) Plasma l-arginine and metabolites of nitric oxide synthase in patients with left-to-right shunt after intracardiac repair. Chest 127:1184-1189
16. Haworth SG (1993) Pulmonary hypertension in childhood. Eur Respir J 6:1037-1043
17. Hirose S, Hosoda Y, Furuya S, Otsuki T, Ikeda E (2000) Expression of vascular endothelial growth factor and its receptors correlates closely with formation of the plexiform lesion in human pulmonary hypertension. Pathol Int 50:472-479
18. Hoeben A, Landuyt B, Highey MS, Wildiers H, Van Oosterom AT, De Bruijn EA (2004) Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 56:549-580
19. Hömme M, Schmitt CP, Mehls O, Schäfer F (2004) Mechanisms of mitogen-activated protein kinase inhibition by parathyroid hormone in osteoblast-like cells. J Am Soc Nephrol 15:2844-2850
20. Humpl T, Campbell R, Stephens D, van Arsdell G, Benson LN, Holtby HM, Slutsky AS, Adatia I (2002) Levels of exhaled nitric oxide before and after surgical and transcatheter device closure of atrial septal defects in children. J Thorac Cardiovasc Surg 124:806-810
21. Janér J, Lassus P, Haglund C, Paavonen K, Alitalo K, Andersson (2006) Pulmonary vascular endothelial growth factor-C in development and lung injury in preterm infants. Am J Respir Crit Care Med 174:326-330
22. Jeltsch M, Kaipanen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K (1997) Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276:1423-1425
23. Laufs U, Endres M, Stagliano N, Amin-Hanjani S, Chui DS, Yang SX, Simoncini T, Yamada M, Rabkin E, Allen PG, Huang PL, Böhm M, Schoen FJ, Moskowitz MA, Liao JK (2000) Neuroprotection mediated by changes in the endothelial actin cytoskeleton. J Clin Invest 106:15-24
24. Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM (2003) Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 285:L222-L231
25. Mata-Greenwood E, Grobe A, Kumar S, Noskina Y, Black SM (2005) Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-β1 and reactive oxygen species: a requirement for NAD(P)H oxidase. Am J Physiol Lung Cell Mol Physiol 289:L288-L298
26. Neagoe PE, Lemieux C, Sirois MG (2005) Vascular endothelial growth factor (VEGF)-A165 induced prostacyclin synthesis requires the activation of VEGF receptor-1 and -2 heterodimer. J Biol Chem 280:9904-9912
27. Parviz M, Bousamra II M, Chammas JH, Birks EK, Presberg KW, Jacobs ER, Nelin LD (1999) Effects of chronic pulmonary overcirculation on pulmonary vascular tone. Ann Thorac Surg 67:522-527
28. Rondelet B, Kerbaul F, Motte S, Beneden R, Remmelink M, Brimioulle S, McEntee K, Wauthy P, Salmon I, Ketelsleger J-M, Naeije R (2003) Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension. Circulation 107:1329-1335
29. Shehata SM, Mooi WJ, Okazaki T (1999) Enhanced expression of vascular endothelial growth factor in lungs of newborn infants with congenital diaphragmatic hernia and pulmonary hypertension. Thorax 54:427-431
30. Stenbøg EV, Steinbrüchel DA, Thomsen AB, Baandrup U, Heickendorff L, Ingerslev J, Andersen NT, Emmertsen K (2001) The pulmonary vasculature in a neonatal porcine model with increased pulmonary blood flow and pressure. Cardiol Young 11:420-430
31. Tang K, Breen EC, Gerber HC, Ferrara NM, Wagner PD (2004) Capillary regression in vascular endothelial growth factor -deficient skeletal muscle. Physiol Genomics 18:63-69
32. Tworetzky W, Moore P, Bekker JM, Bristow J, Black SM, Fineman JR (2000) Pulmonary blood flow alters nitric oxide production in patients undergoing device closure of atrial septal defects. J Am Coll Cardiol 35:463-467
33. Ullmann MV, Tran T, Gebhard MM, Fiehn W, Schnabel PA, Ulmer HE, Hagl S, Gorenflo M (2003) Chronic Blalock-Taussig shunts in piglets: a model of pulmonary vascular disease by high pulmonary blood flow. Cardiol Young 13(Suppl 1):65 (abstract)
34. Voelkel NF, Vandivier RW, Tuder RM (2006) Vascular endothelial growth factor in the lung. Am J Physiol Lung Cell Mol Physiol 290:L209-L221
35. Wilkinson JL (2001) Haemodynamic calculations in the catheter laboratory. Heart 85:113-120