Nitric oxide increases dramatically in air exhaled from lung regions with occluded vessels

Acta Anaesthesiologica Scandinavica

Volumn 47, Issue 3, 2003, Pages 312-318

  Fernandez Mondejar E ^a   Hambraeus Jonzon, Kristina ^b   Roneus A ^c   Hedenstierna, G ^c  

^a Virgen de Las Nievas Hospital   (Spain)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Endothelium derived; Exhaled; Nitric oxide; Pulmonary circulation

Indexed keywords

NITRIC OXIDE; OXYGEN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BALLOON CATHETER; BLOOD VESSEL OCCLUSION; CONTROLLED STUDY; EXPIRED AIR; HEMODYNAMICS; HYPEROXIA; HYPOXIA; LUNG ARTERY PRESSURE; LUNG BLOOD FLOW; LUNG CIRCULATION; LUNG INJURY; LUNG VENTILATION PERFUSION RATIO; NONHUMAN; PRIORITY JOURNAL; SWINE; VASCULAR ENDOTHELIUM;

ANESTHESIA; ANIMALS; BALLOON DILATATION; CARDIAC OUTPUT; LUNG; NITRIC OXIDE; PULMONARY ARTERY; PULMONARY CIRCULATION; PULMONARY WEDGE PRESSURE; RESPIRATION, ARTIFICIAL; SWINE; TRACHEOTOMY;

EID: 0347296027     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2003.00053.x     Document Type: Article

References (26)

1. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 1991; 181: 852-7.
2. Persson MG, Zetterström O, Agrenius V, Ihre E, Gustafsson LE. Single-breath nitric oxide measurements in asthmatic patients and smokers. Lancet 1994; 343: 146-7.
3. Kharitonov SA, Yates D, Robbins A, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994; 343: 133-5.
4. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of human subjects with upper respiratory tract infections. Eur Respir J 1995; 8: 295-7.
5. Stewart TE, Valenza F, Ribeiro SP et al. Increased nitric oxide in exhaled gas as an early marker of lung inflammation in a model of sepsis. Am J Respir Crit Care Med 1995; 15: 713-8.
6. Carlin RE, McGraw DJ, Camporesi EM, Hakim TS. Increased nitric oxide in exhaled gas is a marker of hypovolemic states. J Sur Res 1997; 69: 362-6.
7. Hyde RW, Geigel EJ, Olszowka AJ et al. Determination of production of nitric oxide by lower airways of humans - theory. J Appl Physiol 1997; 82: 1290-6.
8. Buga GM, Gold ME, Fukuto JM, Ignarro LJ. Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension 1991; 17 (2): 187-93.
9. Pohl U, Herlan K, Huang A, Bassenge E. EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries. Am J Physiol 1991; 261: H2016-23.
10. Wilson PS, Thompson WJ, Moore TM, Khimenko PL, Taylor AE. Vasoconstriction increases pulmonary nitric oxide synthesis and circulating cyclic GMP. J Surg Res 1997; 70 (1): 75-83.
11. Koller A, Sun D, Huang A, Kaley G. Corelease of nitric oxide and prostaglandins mediates flow-dependent dilation of rat gracilis muscle arterioles. Am J Physiol 1994; 267: H326-32.
12. Carlin RE, Ferrario L, Boyd JT, Camporesi EM, McGraw DJ, Hakim TS. Determinants of nitric oxide in exhaled gas in the isolated rabbit lung. Am J Respir Crit Care Med 1997; 155: 922-7.
13. Persson MG, Lönnqvist PA, Gustafsson LE. Positive end-expiratory pressure ventilation elicits increases in endogenously formed nitric oxide as detected in air exhaled by rabbits. Anesthesiology 1995; 82: 969-74.
14. Pedoto A, Caruso JE, Nandi J et al. Acidosis stimulates nitric oxide production and lung damage in rats. Am J Respir Crit Care Med 1999; 159: 397-402.
15. Cremona G, Takao M, Higenbottam T. Differences in exhaled nitric oxide (NO) between intact pigs and isolated lungs perfused with Krebs-Dextran-Albumin. Am Rev Respir Dis 1993; 147: A226.
16. Cremona G, Higgenbottam T, Takao M, Hall L, Bower EA. Exhaled nitric oxide in isolated pig lungs. J Appl Physiol 1995; 78: 59-63.
17. Hambraeus-Jonzon K, Chen L, Fredén F, Wiklund NP, Hedenstierna G. Pulmonary vasoconstriction during regional nitric oxide inhalation. Evidence of a blood-borne regulator of nitric oxide synthase activity. Anesthesiology 2001; 95: 102-12.
18. Chen L, He H, Fernández-Mondéjar E et al. Endothelin-1 and nitric oxide synthase in short rebound reaction to short exposure to inhaled nitric oxide. Am J Physiol Heart Circ Physiol 2001; 218 (1): H124-31.
19. Alving K, Weitzberg E, Lundberg JM. Increased amounts of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993; 6: 1360-70.
20. Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 1994; 343: 518-9.
21. Schedin U, Frostell C, Persson MG, Jakobsson J, Andersson G, Gustafsson LE. Contribution from upper and lower airways to exhaled endogenous nitric oxide in humans. Acta Anaesthesiol Scand 1995; 39: 327-32.
22. Dillon WC, Hampl V, Shultz PJ, Rubins JB, Archer SL. Origins of breath nitric oxide in humans. Chest 1996; 110: 930-8.
23. Fujii Y, Goldberg P, Hussain SN. Intrathoracic and extrathoracic sources of exhaled nitric oxide in porcine endotoxemic shock. Chest 1998; 114 (2): 569-76.
24. Martin W, Smith JA, White DG. The mechanisms by which haemoglobin inhibits the relaxation of rabbit aorta induced by nitrovasodilators, nitric oxide or bovine retractor penis inhibitory factor. Br J Pharmacol 1986; 89: 563-71.
25. Iwamoto J, Morin FC. Nitric oxide inhibition varies with hemoglobin saturation. J Appl Physiol 1993; 75 (5): 2332-6.
26. Lamontagne D, Pohl U, Busse R. Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed. Circ Res 1992; 70: 123-30.