Targeted gene transfer increases contractility and decreases oxygen cost of contractility in normal rat hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 5, 2007, Pages

  Sakata, Susumu ^a,b   Lebeche, Djamel ^a   Sakata, Naoya ^a   Sakata, Yuri ^a   Chemaly, Elie R ^a   Liang, Li Fan ^a   Takewa, Yoshiaki ^a   Jeong, Dongtak ^a,c   Park, Woo Jin ^a,c   Kawase, Yoshiaki ^a   Hajjar, Roger J ^a,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Contractile function; Energetics; Oxygen consumption; SERCA2a

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOVIRUS VECTOR; BETA GALACTOSIDASE; CALCIUM; OXYGEN; SODIUM CHLORIDE; RECOMBINANT PROTEIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATHETERIZATION; CONTROLLED STUDY; EXCITATION CONTRACTION COUPLING; GENE DELIVERY SYSTEM; GENE TARGETING; GENE TRANSFER; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE COMPLIANCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE RELAXATION; MALE; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM; SYSTOLIC BLOOD PRESSURE; ANIMAL; CHEMISTRY; GENETICS; HEART CONTRACTION; METABOLISM; METHODOLOGY; OXYGEN CONSUMPTION; PHYSIOLOGY; WISTAR RAT;

ANIMALS; GENE TARGETING; GENE TRANSFER TECHNIQUES; MALE; MYOCARDIAL CONTRACTION; OXYGEN; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; VENTRICULAR FUNCTION, LEFT;

EID: 34250837961     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01310.2006     Document Type: Article

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