Cytokine regulation of periportal fibrosis in humans infected with Schistosoma mansoni: IFN-γ is associated with protection against fibrosis and TNF-α with aggravation of disease

Journal of Immunology

Volumn 169, Issue 2, 2002, Pages 929-936

  Henri, Sandrine ^a   Chevillard, Christophe ^a   Mergani, Adil ^a   Paris, Patricia ^a   Gaudart, Jean ^a   Camilla, Christophe ^a   Dessein, Hélia ^a   Montero, Felix ^a   Elwali, Nasr Eldin M A ^a   Saeed, Osman K ^a   Magzoub, Mubarak ^a   Dessein, Alain J ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOKINE PRODUCTION; DISEASE EXACERBATION; HUMAN; INTERFERON PRODUCTION; LIVER FIBROSIS; LIVER PROTECTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK FACTOR; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS;

EID: 0037100279     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.2.929     Document Type: Article

References (45)

1. The global status of schistosomiasis and its control
2. Chronic human schistosomiasis mansoni: Pathology of the Disse's space
3. Cytokines and cellular crosstalk involved in the activation of fat-storing cells
4. Pathogenesis of liver fibrosis: Role of oxidative stress
5. γ Interferon is the lymphokine and β interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation
6. Selective inhibition of human diploid fibroblast collagen synthesis by interferons
7. Interferon α and γ inhibit proliferation and collagen synthesis of human Ito cells in culture
8. Interferon γ inhibits lipocyte activation and extracellular matrix mRNA expression during experimental liver injury: Implications for treatment of hepatic fibrosis
9. Interferon-γ coordinately up-regulates matrix metalloprotease (MMP)-1 and MMP-3, but not tissue inhibitor of metalloproteases (TIMP), expression in cultured keratinocytes
10. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro
11. Modulation of fibroblast functions by interleukin 1: Increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 α and β
12. Collagen synthesis by human liver (myo) fibroblasts in culture: Evidence for a regulatory role of IL-1β, IL-4, TGFβ and IFNγ
13. γ-interferon treatment inhibits collagen deposition in murine schistosomiasis
14. Cross-regulatory role of interferon-γ (IFN-γ), IL-4 and IL-10 in schistosome egg granuloma formation: In vivo regulation of Th activity and inflammation
15. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response
16. Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis
17. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
18. IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
19. The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections
20. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo
21. IL-10 and the dangers of immune polarization: Excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis
22. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ
23. IFN-γ, IL-12, and TNF-α are required to maintain reduced liver pathology in mice vaccinated with Schistosoma mansoni eggs and IL-12
24. Tumor necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice
25. Tumor necrosis factor α/cachectin stimulates eosinophil oxidant production and toxicity towards human endothelium
26. Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor
27. Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-γ receptor gene
28. A review of the literature on the use of ultrasonography in schistosomiasis with special reference to its use in field studies. III. Schistosoma japonicum
29. Susceptibility to periportal (Symmers) fibrosis in human Schistosoma mansoni infections: Evidence that intensity and duration of infection, gender, and inherited factors are critical in disease progression
30. + T cells in asthma
31. Flow cytometric microsphere-based immunoassay: Analysis of secreted cytokines in whole-blood samples from asthmatics
32. The use of diagnostic ultrasound in schistosomiasis: Attempts at standardization of methodology: Cairo Working Group
33. Schistosoma mansoni: Assessment of morbidity before and after control
34. Cytokine regulation of schistosome-induced granuloma and fibrosis
35. The granulomatous response in murine schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice
36. Cytokines and fibrogenesis
37. Role of IL-4 and IFN-γ in Schistosoma mansoni egg-induced hypersensitivity granuloma formation: Orchestration, relative contribution, and relationship to macrophage function
38. Morbidity due to schistosomiasis mansoni and its control in Subsaharan Africa
39. Cytokine production in acute versus chronic human schistosomiasis mansoni: The cross-regulatory role of interferon-γ and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens
40. Fibronectin and cytokines increase JNK, ERK, AP-1 activity, and transin gene expression in rat hepatic stellate cells
41. Pharmacological regulation of the production of the proinflammatory cytokines TNFα and IL1β
42. Development of eosinophil peroxidase activity and concomitant alteration of the antioxidant defenses in the liver of mice infected with Schistosoma mansoni
43. High levels of TNF, soluble TNF receptors, soluble ICAM-1, and IFN-γ, but low levels of IL-5, are associated with hepatosplenic disease in human schistosomiasis mansoni
44. Tumor necrosis factor in hepatosplenic schistosomiasis
45. Morbidity associated with Schistosoma mansoni infection as determined by ultrasound: A study in Gezira, Sudan