Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice

Journal of Immunology

Volumn 179, Issue 1, 2007, Pages 698-707

  Matsushita, Yukiyo ^a   Hasegawa, Minoru ^a   Matsushita, Takashi ^a   Fujimoto, Manabu ^a   Horikawa, Mayuka ^a   Fujita, Tomoyuki ^a   Kawasuji, Ayako ^a   Ogawa, Fumihide ^b   Steeber, Douglas A ^c   Tedder, Thomas F ^d   Takehara, Kazuhiko ^a   Sato, Shinichi ^b  

^a KANAZAWA UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COLLAGEN; FIBRILLIN 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; L SELECTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GENE MUTATION; LEUKOCYTE; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN FIBROBLAST; SKIN FIBROSIS; SYSTEMIC SCLEROSIS; T LYMPHOCYTE; UPREGULATION;

EID: 34250822809     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.179.1.698     Document Type: Article

References (60)

1. Sato, S., M. Fujimoto, M. Hasegawa, K. Takehara, and T. F. Tedder. 2004. Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. Mol. Immunol. 41: 1123-1133.
2. Simms, R. W., and J. H. Korn. 2002. Cytokine directed therapy in scleroderma: rationale, current status, and the future. Curr. Opin. Rheumatol. 14: 717-722.
3. Derk, C. T., and S. A. Jimenez. 2003. Systemic sclerosis: current views of its pathogenesis. Autoimmun. Rev. 2: 181-191.
4. Roumm, A. D., T. L. Whiteside, T. A. Medsger, Jr., and G. P. Rodnan. 1984. Lymphocytes in the skin of patients with progressive systemic sclerosis: quantification, subtyping, and clinical correlations. Arthritis Rheum. 27: 645-653.
5. Varga, J., and J. H. Korn. 2004. Pathogenesis: emphasis on human data. In Systemic Sclerosis. P. J. Clements and D. E. Furst, eds. Williams & Wilkins, Philadelphia, pp. 63-98.
6. Green, M. C., H. O. Sweet, and L. E. Bunker. 1976. Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton. Am. J. Pathol. 82: 493-512.
7. Bona, C., and N. Rothfield. 1994. Autoantibodies in scleroderma and tightskin mice. Curr. Opin. Immunol. 6: 931-937.
8. Murai, C., S. Saito, K. N. Kasturi, and C. A. Bona. 1998. Spontaneous occurrence of anti-fibrillin-1 autoantibodies in tight-skin mice. Autoimmunity 28: 151-155.
9. Tan, F. K., D. N. Stivers, M. W. Foster, R. Chakraborty, R. F. Howard, D. M. Milewicz, and F. C. Arnett. 1998. Association of microsatellite markers near the fibrillin 1 gene on human chromosome 15q with scleroderma in a Native American population. Arthritis Rheum. 41: 1729-1737.
10. Siracusa, L. D., R. McGrath, Q. Ma, J. J. Moskow, J. Manne, P. J. Christner, A. M. Buchberg, and S. A. Jimenez. 1996. A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation. Genome Res. 6: 300-131.
11. Kasturi, K. N., A. Hatakeyama, C. Murai, R. Gordon, R. G. Phelps, and C. A. Bona. 1997. B-cell deficiency does not abrogate development of cutaneous hyperplasia in mice inheriting the defective fibrillin-1 gene. J. Autoimmun. 10: 505-517.
12. Lemaire, R., J. H. Korn, W. P. Schiemann, and R. Lafyatis. 2004. Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering. J. Invest. Dermatol. 123: 1063-1069.
13. + T cells in the pathogenesis of skin fibrosis in tight skin mice. Eur. J. Immunol. 24: 1463-1466.
14. H2 paradigm. Nat. Rev. Immunol. 4: 583-594.
15. Roberts, A. B., and M. B. Sporn. 1993. Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8: 1-9.
16. Saito, E., M. Fujimoto, M. Hasegawa, K. Komura, Y. Hamaguchi, Y. Kaburagi, T. Nagaoka, K. Takehara, T. F. Tedder, and S. Sato. 2002. CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. J. Clin. Invest. 109: 1453-1462.
17. Ong, C., C. Wong, C. R. Roberts, H. S. Teh, and F. R. Jirik. 1998. Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma. Eur. J. Immunol. 28: 2619-2629.
18. Kodera, T., T. L. McGaha, R. Phelps, W. E. Paul, and C. A. Bona. 2002. Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-β production by fibroblasts. Proc. Natl. Acad. Sci. USA 99: 3800-3805.
19. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76: 301-314.
20. Ley, K., and G. S. Kansas. 2004. Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat. Rev. Immunol. 4: 325-335.
21. Luster, A. D., R. Alon, and U. H. von Andrian. 2005. Immune cell migration in inflammation: present and future therapeutic targets. Nat. Immunol. 6: 1182-1190.
22. Tedder, T. F., D. A. Steeber, and P. Pizcueta. 1995. L-selectin deficient mice have impaired leukocyte recruitment into inflammatory sites. J. Exp. Med. 181: 2259-2264.
23. Dustin, M. L., R. Rothlein, A. K. Bhan, C. A. Dinarello, and T. A. Springer. 1986. Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137: 245-253.
24. Steeber, D. A., M. A. Campbell, A. Basit, K. Ley, and T. F. Tedder. 1998. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc. Natl. Acad. Sci. USA 95: 7562-7567.
25. + lymphocytes in systemic sclerosis. Clin. Exp. Immunol. 124: 474-479.
26. Ihn, H., S. Sato, M. Fujimoto, K. Kikuchi, T. Kadono, K. Tamaki, and K. Takehara. 1997. Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: enhancement by inflammatory cytokines. Br. J. Rheumatol. 36: 1270-1275.
27. Sfikakis, P. P., J. Tesar, H. Baraf, R. Lipnick, G. Klipple, and G. C. Tsokos. 1993. Circulating intercellular adhesion molecule-1 in patients with systemic sclerosis. Clin. Immunol. Immunopathol. 68: 88-92.
28. Gruschwitz, M. S., and G. Vieth. 1997. Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule I expression on scleroderma fibroblasts and endothelial cells by interferon-γ and tumor necrosis factor α in the early disease stage. Arthritis Rheum. 40: 540-550.
29. 2 integrins, intercellular adhesion molecule 1, and endothelial leukocyte adhesion molecule 1 in the skin of patients with systemic sclerosis of recent onset. Arthritis Rheum. 35: 290-298.
30. Sligh, J. E., Jr., C. M. Ballantyne, S. S. Rich, H. K. Hawkins, C. W. Smith, A. Bradley, and A. L. Beaudet. 1993. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA 90: 8529-8533.
31. Arbones, M. L., D. C. Ord, K. Ley, H. Radich, C. Maynard-Curry, D. J. Capon, and T. F. Tedder. 1994. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin (CD62L) deficient mice. Immunity 1: 247-260.
32. McGaha, T., S. Saito, R. G. Phelps, R. Gordon, N. Noben-Trauth, W. E. Paul, and C. Bona. 2001. Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4Rα and transforming growth factor-β genes. J. Invest. Dermatol. 116: 136-143.
33. Meijerink, J., C. Mandigers, L. van de Locht, E. Tonnissen, F. Goodsaid, and J. Raemaekers. 2001. A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR. J. Mol. Diagn. 3: 55-61.
34. Chiang, M. Y., H. Chan, M. A. Zounes, S. M. Freier, W. F. Lima, and C. F. Bennett. 1991. Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J. Biol. Chem. 266: 18162-18171.
35. Stepkowski, S. M., Y. Tu, T. P. Condon, and C. F. Bennett. 1994. Blocking of heart allograft rejection by intercellular adhesion molecule-1 antisense oligonucleotides alone or in combination with other immunosuppressive modalities. J. Immunol. 153: 5336-5346.
36. Sato, S., M. Hasegawa, M. Fujimoto, T. F. Tedder, and K. Takehara. 2000. Quantitative genetic variation in CD19 expression correlates with autoimmunity. J. Immunol. 165: 6635-6643.
37. Everett, E. T., J. L. Pablos, R. A. Harley, E. C. LeRoy, and J. S. Norris. 1995. The role of mast cells in the development of skin fibrosis in tight-skin mutant mice. Comp. Biochem. Physiol. 110A: 159-165.
38. Lesley, J., R. Hyman, and P. W. Kincade. 1993. CD44 and its interaction with extracellular matrix. Adv. Immunol. 54: 271-335.
39. Ong, C. J., S. Ip, S. J. Teh, C. Wong, F. R. Jirik, M. J. Grusby, and H. S. Teh. 1999. A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Cell. Immunol. 196: 60-68.
40. Tsuji-Yamada, J., M. Nakazawa, K. Takahashi, K. Iijima, S. Hattori, K. Okuda, M. Minami, Z. Ikezawa, and T. Sasaki. 2001. Effect of IL-12 encoding plasmid administration on tight-skin mouse. Biochem. Biophys. Res. Commun. 280: 707-712.
41. Longhurst, C. M., and L. K. Jennings. 1998. Integrin-mediated signal transduction. Cell Mol. Life Sci. 54: 514-526.
42. Shi-wen, X., M. Panesar, R. Vancheeswaran, J. Mason, D. Haskard, C. Black, I. Olsen, and D. Abraham. 1994. Expression and shedding of intercellular adhesion molecule 1 and lymphocyte function-associated antigen 3 by normal and scleroderma fibroblasts: effects of interferon-γ, tumor necrosis factor α, and estrogen. Arthritis Rheum. 37: 1689-1697.
43. Needleman, B. W. 1990. Increased expression of intercellular adhesion molecule 1 on the fibroblasts of scleroderma patients. Arthritis Rheum. 33: 1847-1851.
44. Abraham, D., S. Lupoli, A. McWhirter, C. Plater-Zyberk, T. H. Piela, J. H. Korn, I. Olsen, and C. Black. 1991. Expression and function of surface antigens on scleroderma fibroblasts. Arthritis Rheum. 34: 1164-1172.
45. Kahari, V. M., M. Sandberg, H. Kalimo, T. Vuorio, and E. Vuorio. 1988. Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization. J. Invest. Dermatol. 90: 664-670.
46. Scharlfetter, K., B. Lankat-Buttgereit, and T. Krieg. 1988. Localization of collagen mRNA in normal and scleroderma skin by in-situ hybridization. Eur. J. Clin. Invest. 18: 9-17.
47. Piela-Smith, T. H., G. Broketa, A. Hand, and J. H. Korn. 1992. Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4. J. Immunol. 148: 1375-1381.
48. Kim, J. J., A. Tsai, L. K. Nottingham, L. Morrison, D. M. Cunning, J. Oh, D. J. Lee, K. Dang, T. Dentchev, A. A. Chalian, et al. 1999. Intracellular adhesion molecule-1 modulates β-chemokines and directly costimulates T cells in vivo. J. Clin. Invest. 103: 869-877.
49. Walker, M. A., R. A. Harley, F. A. DeLustro, and E. C. LeRoy. 1989. Adoptive transfer of tsk skin fibrosis to +/+ recipients by tsk bone marrow and spleen cells. Proc. Soc. Exp. Biol. Med. 192: 196-200.
50. Hasegawa, M., Y. Hamaguchi, K. Yanaba, J. D. Bouaziz, J. Uchida, M. Fujimoto, T. Matsushita, Y. Matsushita, M. Horikawa, K. Komura, et al. 2006. B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. Am. J. Pathol. 169: 954-966.
51. Saito, S., H. Nishimura, T. D. Brumeanu, S. Casares, A. C. Stan, T. Honjo, and C. A. Bona. 1999. Characterization of mutated protein encoded by partially duplicated fibrillin-1 gene in tight skin (TSK) mice. Mol. Immunol. 36: 169-176.
52. Kielty, C. M., M. Raghunath, L. D. Siracusa, M. J. Sherratt, R. Peters, C. A. Shuttleworth, and S. A. Jimenez. 1998. The tight skin mouse: demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils. J. Cell Biol. 140: 1159-1166.
53. Saito, S., H. Nishimura, R. G. Phelps, I. Wolf, M. Suzuki, T. Honjo, and C. Bona. 2000. Induction of skin fibrosis in mice expressing a mutated fibrillin-1 gene. Mol. Med. 6: 825-836.
54. Crooke, S. T. 1993. Progress toward oligonucleotide therapeutics: pharmacodynamic properties. FASEB J. 7: 533-539.
55. Bennett, C. F., and S. T. Crooke. 1994. Regulation of endothelial cell adhesion molecule expression with antisense oligonucleotides. Adv. Pharmacol. 28: 1-43.
56. Bennett, C. F., T. P. Condon, S. Grimm, H. Chan, and M. Y. Chiang. 1994. Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. J. Immunol. 152: 3530-3540.
57. Bennett, C. F., D. Kornbrust, S. Henry, K. Stecker, R. Howard, S. Cooper, S. Dutson, W. Hall, and H. I. Jacoby. 1997. An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice. J. Pharmacol. Exp. Ther. 280: 988-1000.
58. Yacyshyn, B. R., C. Barish, J. Goff, D. Dalke, M. Gaspari, R. Yu, J. Tami, F. A. Dorr, and K. L. Sewell. 2002. Dose ranging pharmacokinetic trial of high-dose alicaforsen (intercellular adhesion molecule-1 antisense oligodeoxynucleotide) (ISIS 2302) in active Crohn's disease. Aliment Pharmacol. Ther. 16: 1761-1770.
59. Van Deventer, S. J., J. A. Tami, and M. K. Wedel. 2004. A randomized, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis. Gut 53: 1646-1651.
60. Maksymowych, W. P., W. D. Blackburn, Jr., J. A. Tami, and W. R. Shanahan, Jr. 2002. A randomized, placebo controlled trial of an antisense oligodeoxynucleotide to intercellular adhesion molecule-1 in the treatment of severe rheumatoid arthritis. J. Rheumatol. 29: 447-453.