Upregulation of CD4+ NKT cells is important for allograft survival in staphylococcal-enterotoxin-B-treated rats after high-risk corneal transplantation

Ophthalmic Research

Volumn 39, Issue 3, 2007, Pages 130-138

  Jie, Ying ^a   Pan, Zhiqiang ^b   Xu, Liang ^a   Chen, Yu ^c   Zhang, Wenhua ^a   Wu, Yuying ^a   Peng, Hong ^d  

^a BEIJING INSTITUTE OF OPHTHALMOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Corneal transplantation, rat; Natural killer T cells; Staphylococcal enterotoxin B

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; STAPHYLOCOCCUS ENTEROTOXIN B;

ALLOGRAFT; ANIMAL CELL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; CORNEA TRANSPLANTATION; FEMALE; GRAFT SURVIVAL; HIGH RISK PATIENT; LYMPHOCYTE PROLIFERATION; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; STAPHYLOCOCCUS;

ANIMALS; ANTIGENS, CD4; AQUEOUS HUMOR; BIOLOGICAL MARKERS; CELL PROLIFERATION; CORNEAL TRANSPLANTATION; DISEASE MODELS, ANIMAL; ENTEROTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; GRAFT REJECTION; GRAFT SURVIVAL; INTERLEUKIN-10; INTERLEUKIN-2; KILLER CELLS, NATURAL; RATS; RATS, INBRED F344; RATS, INBRED LEW; RISK FACTORS; SUPERANTIGENS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; UP-REGULATION;

EID: 34250820367     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000102934     Document Type: Article

References (25)

1. Niederkorn JY: Immune privilege and immune regulation in the eye. Adv Immunol 1990;48:191-226.
2. Dana MR, Streilein JW: Loss and restoration of immune privilege in eye with corneal neovascularization. Invest Ophthalmol Vis Sci 1996;37:2485-2494.
3. Niederkorn JY: Immunology and immunomodulation of corneal transplantation. Int Rev Immunol 2002;21:173-196.
4. Aroeira LS, Mouton CG, Toran JL, Ward ES, Martinez C: Anti-Vβ8 antibodies induce and maintain staphylococcal enterotoxin B-triggered Vβ8+T cells anergy. Eur J Immunol 1999;29:437-445.
5. Assenmacher M, Löhning M, Scheffold A, Manz RA, Schmitz J, Radbruch A: Sequential production of IL-2, IFN-γ and IL-10 by individual staphylococcal enterotoxin B-activated T helper lymphocytes. Eur J Immunol 1998;28:1534-1543.
6. Renno T, Attinger A, Locatelli S, Bakker T, Vacheron S, MacDonald HR: Cutting edge: apoptosis of superantigen-activated T cells occurs preferentially after a discrete number of cell divisions in vivo. J Immunol 1999; 162:6312-6315.
7. Bendelac A, Rivera MN, Park SH, Roark JH: Mouse CD1-specific NK1 cells: development, specificity, and function. Annu Rev Immunol 1997;15:535-562.
8. Bendelac A, Lantz O, Quimby ME, Yewdell JW, Bennink JR, Brutkiewicz RR: CD1 recognition by mouse NK1+ T lymphocytes. Science 1995;268:863-865.
9. Bendelac A: Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J Exp Med 1995;182:2091-2096.
10. Sonoda KH, Stein-Streilein JS: Ocular immune privilege and CD1d-reactive natural killer T cells. Cornea 2002;21(suppl 1):S33-S38.
11. Sonoda KH, Taniguchi M, Stein-Streilein JS: Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. J Immunol 2002;168:2028-2034.
12. Sonoda KH, Exley M, Snapper S, Balk SP, Stein-Streilein JS: CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med 1999;190:1215-1226.
13. Pan Z, Chen Y, Zhang W, Jie Y, Li N, Wu Y: Rat corneal allograft survival prolonged by the superantigen staphylococcal enterotoxin B. Invest Ophthalmol Vis Sci 2003;44:3346-3351.
14. Dana MR, Yamada J, Streilein JW: Topical interleukin-1 receptor antagonist promotes corneal transplant at survival. Transplantation 1997;63:1501-1507.
15. Avraham BN: Staphylococcal enterotoxin B as a potent suppressant of T cell proliferative responses in rats. Eur J Immunol 1991;21:815-818.
16. Sabapathy TK, Hwang LA, Hui KM: Differential effect of staphylococcal enterotoxin B upon the induction of tolerance on peripheral CD4+Vβ8+ and CD4+Vβ8+ T cells. Cell Immunol 1994;158:83-95.
17. Yamagami S, Kawashima H, Endo H, Tsuru T, Shibui H, Kagawa Y, Hori J, Yamagami H, Isobe M: Cytokine profiles of aqueous humor and graft in orthotopic mouse corneal transplantation. Transplantation 1998;66:1504-1510.
18. Boles JW, Pitt ML, LeClaire RD, Gibbs PH, Torres E, Dyas B, Ulrich RG, Bavari S: Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity. Clin Immunol 2003;108:51-59.
19. Watson AR, Mittler JN, Lee WT: Staphylococcal enterotoxin B induces anergy to conventional peptide in memory T cells. Cell Immunol 2003;222:144-155.
20. Sköld M, Behar SM: Role of CD1d-restricted NKT cells in microbial immunity. Infect Immun 2003;71:5447-5455.
21. Thomas SY, Hou R, Boyson JE, Means TK, Hess C, Olson DP, Strominger JL, Brenner MB, Gumperz JE, Wilson SB, Luster AD: CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol 2003;171:2571-2580.
22. Lisbonne M, Leite-De-Moraes MC: Invariant Vα14 NKT lymphocytes: a double-edged immuno-regulatory T cell population. Eur Cytokine Netw 2003;14:4-14.
23. Sonoda KH, Faunce DE, Taniguchi M, Exley M, Balk S, Stein-Streilein JS: NKT cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J Immunol 2001;166:42-50.
24. Nakamura T, Sonoda KH, Faunce DE, Gumperz J, Yamamura T, Miyake S, Stein-Streilein JS: CD4+ NKT cells, but not conventional CD4+ T cells are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site. J Immunol 2003;171:1266-1271.
25. Wang Y, Goldschneider I, O'Rourke J, Cone RE: Blood mononuclear cells induce regulatory NKT thymocytes in anterior chamber-associated immune deviation. J Leukoc Biol 2001;69:741-746.