Anti-Vβ8 antibodies induce and maintain staphylococcal enterotoxin B-triggered Vβ8+ T cell anergy

European Journal of Immunology

Volumn 29, Issue 2, 1999, Pages 437-445

  Aroeira, Luiz Stark ^a,c   Mouton, Concepción G ^a   Toran, José L ^a   Ward, Elizabeth Sally ^b   Martínez A, Carlos ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Instituto de Pesquisa Einstein   (Brazil)

Author keywords

Anergy; Antibody; Staphylococcal enterotoxin B; T cell receptor

Indexed keywords

MONOCLONAL ANTIBODY; STAPHYLOCOCCUS ENTEROTOXIN B; T LYMPHOCYTE ANTIBODY; ANTIBODY; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MALE; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOMA; ANIMAL; B LYMPHOCYTE; BAGG ALBINO MOUSE; C57BL MOUSE; DRUG EFFECT; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; NUDE MOUSE;

ANIMALS; ANTIBODIES; B-LYMPHOCYTES; ENTEROTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0032586824     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199902)29:02<437::AID-IMMU437>3.0.CO;2-A     Document Type: Article

References (37)

1. Cnator, H., Crump, A. L., Raman, V. K., Liu, H., Markowitz, J. S., Grusby, M. J. and Glimber, L. H., Immunoregulatory effects of superantigen: Interactions of Staphylococcal enterotoxins with host MHC and non-MHC products. Immunol. Rev. 1993. 131: 27-34.
2. + T cells in mice tolerant to S.aureus enterotoxin B. Nature 1991. 349: 245-248.
3. b mice by maternal preimmunization. Immunology 1991. 72: 219-225.
4. Marrack, P., Kushnir, E. and Kappler, J., A maternally inherited superantigen encoded by a mammary tumor virus. Nature 1991. 329: 524-526.
5. Marrack, P. and Kappler, J., The staphylococcal enterotoxins and their relatives. Science 1990. 248: 705-711.
6. + T cell in Staphylococcus enterotoxin B-primed mice. J. Exp. Med. 1990. 172: 1065-1106.
7. Gonzalo, J. A., Baixeiras, E., Gonzáles-Garcia, A., Goerge-Chandy, A., van Rooijen, N., Martinez-A., C. and Kroemer, G., Differential in vivo effects of a superantigen and an antibody target to the same T cell receptor. J. Immunol. 1994. 152: 1597-1608.
8. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 1991. 349: 245-248.
9. + peripheral T cells responding to staphylococcal enterotoxin B in vivo. Eur. J. Immunol. 1991. 21: 1963-1966.
10. Aroeira, L. S., Moreno, M. C. and Martinez-A., C., In vivo activation of T-cell induction into the primed phenotype and programmed cells death by staphylococcal enterotoxin B. Scand. J. Immunol. 1996. 43: 545-550.
11. Lussow, A. R. and MacDonald, H. R., Differential effects of superantigen-induced "anergy" on priming and effector stages of a T cell-dependent antibody response. Eur. J. Immunol. 1994. 24: 445-449.
12. Matsumoto, Y. and Fujiwara, M., Immunomodulation of experimental autoimmune encephalomyelitis by staphylococcal enterotoxin D. Cell. Immunol. 1993. 149: 268-278.
13. Kalman, B., Lublin, F. D., Lattime, E., Joseph, J. and Knobler, R. L., Effects of staphylococcal enterotoxin B on T cell receptor V beta utilization and clinical manifestations of experimental allergic encephalomyelitis. J. Neuroimmunol. 1993. 45: 83-88.
14. Racke, M. K., Quigley, L., Cannella, B., Raine, C. S., McFarlin, D. E. and Scott, D. E., Superantigen modulation of experimental allergic encephalomyelitis: activation of anergy determines outcome. J. Immunol. 1994. 152: 2051-2059.
15. Soos, J. M., Schiffenbauer, J. and Johnson, H. M., Treatment of PL/J mice with the superantigen, staphylococcal enterotoxin B, prevents development of experimental allergic encephalomyelitis. J. Neuroimmunol. 1993. 43: 39-43.
16. Roach, B., Tanchot, C. and von Boehmer, H., Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen. J. Exp. Med. 1993. 177: 1517-1521.
17. Rocken, M., Urban, J. F. and Shevach, E. M., Infection breaks T-cell tolerance. Nature 1992. 359: 79-82.
18. Lee, W. T. and Viteta, E. S., Memory T cells are anergic to the superantigen staphylococcal enterotoxin B. J. Exp. Med. 1992. 176: 575-579.
19. Heeg, K., Gaus, H., Griese, D., Bendigs, S., Miethke, T. and Wagner, H., Superantigen-reative T cells that display an anergic phenotype in vitro appear functional in vivo. Int. Immunol. 1995. 7: 105-114.
20. Williams, O., Aroeira, L. S. and Mengel, J., T-cell dependent antibody response to Staphylococcal enterotoxin B. Scand. J. Immunol. 1995. 42: 305-310.
21. Aroeria, L. S., Williams, O., Borlado, L. R., Carrera, A. and Martinez-A., C., Evidence for B cell participation in the in vivo and in vitro maintenance of in vivo staphylococcal enterotoxin B-induced T cell anergy. Int. Immunol. 1997. 9: 65-72.
22. Migita, K. and Ochi, A., The fate of anergic T cells in vivo. J. Immunol. 1993. 150: 763-770.
23. Vella, A. T., Scherer, M. T., Shultz, L., Kappler, J. and Marrack, P., B-cells are not essential for peripheral T-cell tolerance. Proc. Natl. Acad. Sci. USA 1996. 93: 951-955.
24. - helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4 and interferon γ. J. Exp. Med. 1991. 174: 547-559.
25. + helper T lymphocytes identified by the expression of PgP-1. J. Exp. Med. 1989. 169: 1461-1467.
26. hi "memory" phenotype display characteristics of activated cells in G1 stage of cell cycle. Cell. Immunol. 1992. 141: 433-443.
27. + memory T cells from the spleen lack Mel-14, the lymph node homing receptor. J. Immunol. 1992. 148: 324-331.
28. Williams, O., Aroeira, L. S. and Martinez-A., C., Absence of peripheral clonal deletion and anergy in immune responses of T cell-reconstituted athymic mice. Eur. J. Immunol. 1994. 24: 579-584.
29. Zhou, S.-R. and Whitaker, J. N., Specific modulation of T cells and murine experimental allergic encephalomyelitis by monoclonal anti-idiotypic antibodies. J. Immunol. 1993. 150: 1629-1642.
30. Zhou, S. R., De Silva, T. S., Han, Q. and Whitaker, J. N., Monoclonal antibodies to a TCR idiotope modulate the superantigen-induced response of encephalitogenic rat T cells. Int. Immunol. 1994. 6: 1865-1874.
31. Miethke, T., Wahl, C., Heeg, K. and Wagner, H., Bacterial superantigen induce T cells unresposiveness in B cell-deficient mice. Eur. J. Immunol. 1995. 25: 3187-3190.
32. Grossman, Z. and Paul, W., Adaptive cellular interaction in the immune system: The tunable activation threshold and the significance of sub-threshold response. Proc. Natl. Acad. Sci. USA 1992. 89: 10365-10369.
33. Freitas, A., Vialle, A.-C., Sundblad, A., Heuser, C. and Coutinho, A., Normal serum immunoglobulins participate in the selection of peripheral B cell repertoires. Proc. Natl. Acad. Sci. USA 1991. 88: 5640-5649.
34. Marcos, M. A. R., De la Hera, A., Pereira, P., Marquez, C., Toribio, M., Coutinho, A. and Martinez-A., C., B cell participation in the recursive selection of T cell repertoires. Eur. J. Immunol. 1988. 18: 1015-1020.
35. Marcos, M. A. R., Toribio, M. L., De la Hera, A., Marquez, C., Gaspar, M. L. and Martinez-A., C., Mutual cell interactions and the selection of immune repertoires. Immunol. Today 1988. 9: 204-207.
36. Wolf, S. D., Dittel, B. N., Hardardottir, F. and Janeway, C. A., Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J. Exp. Med. 1996. 184: 2271-2278.
37. Ward, E. S., Secretion of T cell receptor fragments from recombinant Escherichia coli cells. J. Mol. Biol. 1992. 224: 885-890.