Hippocampal 11β-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression has a diurnal variability that is lost in the obese zucker rat

Endocrinology

Volumn 148, Issue 6, 2007, Pages 2716-2722

  Burén, Jonas ^a   Bergström, Sven Anders ^a   Loh, Edmund ^a   Söderström, Ingegerd ^a   Olsson, Tommy ^a   Mattsson, Cecilia ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOSTERONE; GLUCOCORTICOID; MESSENGER RNA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DENTATE GYRUS; ENZYME ACTIVITY; EPIDIDYMIS FAT; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIVER; MALE; METABOLISM; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; RETROPERITONEAL FAT; SPRAGUE DAWLEY RAT; SUBCUTANEOUS FAT; ZUCKER RAT; ANIMAL; BLOOD; BRAIN CORTEX; COMPARATIVE STUDY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; CEREBRAL CORTEX; CIRCADIAN RHYTHM; CORTICOSTERONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HIPPOCAMPUS; MALE; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RNA, MESSENGER;

EID: 34250799911     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-0897     Document Type: Article

References (58)

1. Dallman MF, Akana SF, Bhatnagar S, Bell ME, Strack AM 2000 Bottomed out: metabolic significance of the circadian trough in glucocorticoid concentrations. Int J Obes Relat Metab Disord 24(Suppl 2):S40-S46
2. Seckl JR, Walker BR 2004 11β-Hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory. Trends Endocrinol Metab 15:418-424
3. Rask E, Olsson T, Söderberg S, Andrew R, Livingstone DE, Johnson O, Walker BR 2001 Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 86:1418-1421
4. Rask E, Walker BR, Söderberg S, Livingstone DE, Eliasson M, Johnson O, Andrew R, Olsson T 2002 Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 87:3330-3336
5. Lindsay RS, Wake DJ, Nair S, Bunt J, Livingstone DE, Permana PA, Tataranni PA, Walker BR 2003 Subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab 88:2738-2744
6. Wake DJ, Rask E, Livingstone DE, Soderberg S, Olsson T, Walker BR 2003 Local and systemic impact of transcriptional up-regulation of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab 88:3983-3988
7. Livingstone DE, Jones GC, Smith K, Jamieson PM, Andrew R, Kenyon CJ, Walker BR 2000 Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology 141:560-563
8. Gomez-Sanchez EP, Ganjam V, Chen YJ, Liu Y, Zhou MY, Toroslu C, Romero DG, Hughson MD, de Rodriguez A, Gomez-Sanchez CE 2003 Regulation of 11β-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol. Am J Physiol Endocrinol Metab 285:E272-E279
9. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS 2001 A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166-2170
10. Masuzaki H, Yamamoto H, Kenyon CJ, Elmquist JK, Morton NM, Paterson JM, Shinyama H, Sharp MG, Fleming S, Mullins JJ, Seckl JR, Flier JS 2003 Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest 112:83-90
11. Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ 1997 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 94:14924-14929
12. Morton NM, Holmes MC, Fievet C, Staels B, Tailleux A, Mullins JJ, Seckl JR 2001 Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem 276:41293-41300
13. Morton NM, Paterson JM, Masuzaki H, Holmes MC, Staels B, Fievet C, Walker BR, Flier JS, Mullins JJ, Seckl JR 2004 Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 53:931-938
14. De Kloet ER, Vreugdenhil E, Oitzl MS, Joels M 1998 Brain corticosteroid receptor balance in health and disease. Endocr Rev 19:269-301
15. Ljung T, Andersson B, Bengtsson BA, Bjorntorp P, Marin P 1996 Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study. Obes Res 4:277-282
16. Rosmond R, Dallman MF, Bjorntorp P 1998 Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 83:1853-1859
17. Walker BR, Soderberg S, Lindahl B, Olsson T 2000 Independent effects of obesity and cortisol in predicting cardiovascular risk factors in men and women. J Intern Med 247:198-204
18. Ljung T, Holm G, Friberg P, Andersson B, Bengtsson BA, Svensson J, Dallman M, McEwen B, Bjorntorp P 2000 The activity of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system in relation to waist/hip circumference ratio in men. Obes Res 8:487-495
19. Martin RJ, Wangsness PJ, Gahagan JH 1978 Diurnal changes in serum metabolites and hormones in lean and obese Zucker rats. Horm Metab Res 10:187-192
20. Fletcher JM, Haggarty P, Wahle KW, Reeds PJ 1986 Hormonal studies of young lean and obese Zucker rats. Horm Metab Res 18:290-295
21. Walker CD, Scribner KA, Stern JS, Dallman MF 1992 Obese Zucker (fa/fa) rats exhibit normal target sensitivity to corticosterone and increased drive to adrenocorticotropin during the diurnal trough. Endocrinology 131:2629-2637
22. Cunningham JJ, Calles-Escandon J, Garrido F, Carr DB, Bode HH 1986 Hypercorticosteronuria and diminished pituitary responsiveness to corticotropin-releasing factor in obese Zucker rats. Endocrinology 118:98-101
23. White BD, Corll CB, Porter JR 1989 The metabolic clearance rate of corticosterone in lean and obese male Zucker rats. Metabolism 38:530-536
24. Fraser R, Ingram MC, Anderson NH, Morrison C, Davies E, Connell JM 1999 Cortisol effects on body mass, blood pressure, and cholesterol in the general population. Hypertension 33:1364-1368
25. Stewart PM, Boulton A, Kumar S, Clark PM, Shackleton CH 1999 Cortisol metabolism in human obesity: impaired cortisone→cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 84:1022-1027
26. Lottenberg SA, Giannella-Neto D, Derendorf H, Rocha M, Bosco A, Carvalho SV, Moretti AE, Lerario AC, Wajchenberg BL 1998 Effect of fat distribution on the pharmacokinetics of cortisol in obesity. Int J Clin Pharmacol Ther 36:501-505
27. Purnell JQ, Brandon DD, Isabelle LM, Loriaux DL, Samuels MH 2004 Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women. J Clin Endocrinol Metab 89:281-287
28. Strain GW, Zumoff B, Kream J, Strain JJ, Levin J, Fukushima D 1982 Sex difference in the influence of obesity on the 24 hr mean plasma concentration of cortisol. Metabolism 31:209-212
29. Jessop DS, Dallman MF, Fleming D, Lightman SL 2001 Resistance to glucocorticoid feedback in obesity. J Clin Endocrinol Metab 86:4109-4114
30. Herman SP, Watson SJ, Chao HM, Coirini H, McEwan BS 1993 Diurnal regulation of glucocorticoid receptor and mineralocorticoid receptor mSNAs in rat hippocampus. Mol Cell Neurosci 4:181-190
31. Gratsias Y, Moutsatsou P, Chrysanthopoulou G, Tsagarakis S, Thalassinos N, Sekeris CE 2000 Diurnal changes in glucocorticoid sensitivity in human peripheral blood samples. Steroids 65:851-856
32. Mattsson C, Lai M, Noble J, McKinney E, Yau JL, Seckl JR, Walker BR 2003 Obese Zucker rats have reduced mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 1 expression in hippocampus- implications for dysregulation of the hypothalamic-pituitary-adrenal axis in obesity. Endocrinology 144:2997-3003
33. Paxinos G, Watson C 1998 The rat brain in stereotaxic coordinates. Orlando, FL: Academic Press
34. Rönnbäck A, Dahlqvist P, Bergström SA, Olsson T 2005 Diurnal effects of enriched environment on immediate early gene expression in the rat brain. Brain Res 1046:137-144
35. Lakshmi V, Monder C 1988 Purification and characterization of the corticosteroid 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex. Endocrinology 123:2390-2398
36. Moisan MP, Seckl JR, Edwards CR 1990 11β-Hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus, and cortex. Endocrinology 127:1450-1455
37. Seckl JR, Olsson T 1995 Glucocorticoid hypersecretion and the age-impaired hippocampus: cause or effect? J Endocrinol 145:201-211
38. Harris HJ, Kotelevtsev Y, Mullins JJ, Seckl JR, Holmes MC 2001 Intracellular regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11β-HSD-1-deficient mice. Endocrinology 142:114-120
39. Livingstone DE, Kenyon CJ, Walker BR 2000 Mechanisms of dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. J Endocrinol 167:533-539
40. Alingh Prins A, de Jong-Nagelsmit A, Keijser J, Strubbe JH 1986 Daily rhythms of feeding in the genetically obese and lean Zucker rats. Physiol Behav 38:423-426
41. Coutinho AE, Campbell JE, Fediuc S, Riddell MC 2006 Effect of voluntary exercise on peripheral tissue glucocorticoid receptor content and the expression and activity of 11β-HSD1 in the Syrian hamster. J Appl Physiol 100:1483-1488
42. Bujalska IJ, Kumar S, Stewart PM 1997 Does central obesity reflect "Cushing's disease of the omentum"? Lancet 349:1210-1213
43. Tomlinson JW, Stewart PM 2001 Cortisol metabolism and the role of 11β-hydroxysteroid dehydrogenase. Best Pract Res Clin Endocrinol Metab 15:61-78
44. Tomlinson JW, Moore J, Cooper MS, Bujalska I, Shahmanesh M, Burt C, Strain A, Hewison M, Stewart PM 2001 Regulation of expression of 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue: tissue-specific induction by cytokines. Endocrinology 142:1982-1989
45. Friedberg M, Zoumakis E, Hiroi N, Bader T, Chrousos GP, Hochberg Z 2003 Modulation of 11β-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers. J Clin Endocrinol Metab 88:385-393
46. Wisse BE, Ogimoto K, Morton GJ, Wilkinson CW, Frayo RS, Cummings DE, Schwartz MW 2004 Physiological regulation of hypothalamic IL-1β gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab 287:E1107-E1113
47. Bestetti GE, Abramo F, Guillaume-Gentil C, Rohner-Jeanrenaud F, Jeanrenaud B, Rossi GL 1990 Changes in the hypothalamo-pituitary-adrenal axis of genetically obese fa/fa rats: a structural, immunocytochemical, and morphometrical study. Endocrinology 126:1880-1887
48. Timofeeva E, Richard D 1997 Functional activation of CRH neurons and expression of the genes encoding CRH and its receptors in food-deprived lean (Fa/?) and obese (fa/fa) Zucker rats. Neuroendocrinology 66:327-340
49. Pesonen U, Huupponen R, Rouru J, Koulu M 1992 Hypothalamic neuropeptide expression after food restriction in Zucker rats: evidence of persistent neuropeptide Y gene activation. Brain Res Mol Brain Res 16:255-260
50. Plotsky PM, Thrivikraman KV, Watts AG, Hauger RL 1992 Hypothalamic-pituitary-adrenal axis function in the Zucker obese rat. Endocrinology 130:1931-1941
51. Westerbacka J, Corner A, Kannisto K, Kolak M, Makkonen J, Korsheninnikova E, Nyman T, Hamsten A, Fisher RM, Yki-Jarvinen H 2006 Acute in vivo effects of insulin on gene expression in adipose tissue in insulin-resistant and insulin-sensitive subjects. Diabetologia 49:132-140
52. Irani BG, Dunn-Meynell AA, Levin BE 2007 Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Endocrinology 148:310-316
53. Jamieson PM, Fuchs E, Flugge G, Seckl JR 1997 Attenuation of hippocampal 11β-hydroxysteroid dehydrogenase type 1 by chronic psychosocial stress in the tree shrew. Stress 2:123-132
54. Low SC, Moisan MP, Noble JM, Edwards CR, Seckl JR 1994 Glucocorticoids regulate hippocampal 11β-hydroxysteroid dehydrogenase activity and gene expression in vivo in the rat. J Neuroendocrinol 6:285-290
55. Pelletier G, Luu-The V, Li S, Bujold G, Labrie F 2007 Localization and glucocorticoid regulation of 11β-hydroxysteroid dehydrogenase type 1mRNA in the male mouse forebrain. Neuroscience 145:110-115
56. Sandeep TC, Yau JL, MacLullich AM, Noble J, Deary IJ, Walker BR, Seckl JR 2004 11β-Hydroxysteroid dehydrogenase inhibition improves cognitive function in healthy elderly men and type 2 diabetics. Proc Natl Acad Sci USA 101:6734-6739
57. Stenlof K, Wernstedt I, Fjallman T, Wallenius V, Wallenius K, Jansson JO 2003 Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects. J Clin Endocrinol Metab 88:4379-4383
58. Sapolsky RM 1992 Do glucocorticoid concentrations rise with age in the rat? Neurobiol Aging 13:171-174