Renin-Angiotensin System and Nitric Oxide Synthase Gene Polymorphisms in Relation to Stroke

American Journal of Hypertension

Volumn 20, Issue 7, 2007, Pages 764-770

  Henskens, Léon H ^a   Kroon, Abraham A ^a   van der Schouw, Yvonne T ^b   Schiffers, Paul M ^c   Grobbee, Diederick E ^b   de Leeuw, Peter W ^a   Bots, Michiel L ^b  

^a Division of General Internal Medicine   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

genetics; nitric oxide synthase; population based; Renin angiotensin system; stroke

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; NITRIC OXIDE SYNTHASE; RENIN;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE INTERACTION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE PHENOTYPE CORRELATION; HAZARD ASSESSMENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK ASSESSMENT; RISK FACTOR; STROKE; SYSTOLIC BLOOD PRESSURE; UNIVARIATE ANALYSIS;

AGED; CEREBROVASCULAR ACCIDENT; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HUMANS; MIDDLE AGED; NETHERLANDS; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, ANGIOTENSIN, TYPE 1; RISK FACTORS;

EID: 34250774588     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2007.02.012     Document Type: Article

References (24)

1. Feigin V.L., Lawes C.M., Bennett D.A., and Anderson C.S. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol 2 (2003) 43-53
2. Hassan A., and Markus H.S. Genetics and ischaemic stroke. Brain 123 (2000) 1784-1812
3. Szolnoki Z., Somogyvari F., Kondacs A., Szabo M., Fodor L., Bene J., and Melegh B. Evaluation of the modifying effects of unfavourable genotypes on classical clinical risk factors for ischaemic stroke. J Neurol Neurosurg Psychiatry 74 (2003) 1615-1620
4. Yan C., Kim D., Aizawa T., and Berk B.C. Functional interplay between angiotensin II and nitric oxide; cyclic GMP as a key mediator. Arterioscler Thromb Vasc Biol 23 (2003) 26-36
5. Rubattu S., Di Angelantonio E., Stanzione R., Zanda B., Evangelista A., Pirisi A., De Paolis P., Cota L., Brunetti E., and Volpe M. Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant. J Hypertens 22 (2004) 2129-2134
6. Hindorff L.A., Heckbert S.R., Tracy R., Tang Z., Psaty B.M., Edwards K.L., Siscovick D.S., Kronmal R.A., and Nazar-Stewart V. Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events. Am J Hypertens 15 (2002) 1050-1056
7. Brenner D., Labreuche J., Poirier O., Cambien F., and Amarenco P. Renin-angiotensin-aldosterone system in brain infarction and vascular death. Ann Neurol 58 (2005) 131-138
8. Elbaz A., Poirier O., Moulin T., Chedru F., Cambien F., Amarenco P., and The GENIC Investigators. Association between the Glu298Asp polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction. Stroke 31 (2000) 1634-1639
9. Boker L.K., van Noord P.A., van der Schouw Y.T., Koot N.V., Bueno de Mesquita H.B., Riboli E., Grobbee D.E., and Peeters P.H. Prospect-EPIC Utrecht: study design and characteristics of the cohort population. European Prospective Investigation into Cancer and Nutrition. Eur J Epidemiol 17 (2001) 1047-1053
10. Prentice R.L. A case-cohort design for epidemiologic cohort studies and disease prevention trials. Biometrika 73 (1986) 1-11
11. Veldman B.A., Spiering W., Doevendans P.A., Vervoort G., Kroon A.A., de Leeuw P.W., and Smits P. The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide. J Hypertens 20 (2002) 2023-2027
12. Chau N.P., Safar M.E., Weiss Y.A., London G.M., Simon A.C., and Milliez P.L. Relationships between cardiac output, heart rate and blood volume in essential hypertension. Clin Sci Mol Med 54 (1978) 175-180
13. Rubattu S., Giliberti R., and Volpe M. Etiology and pathophysiology of stroke as a complex trait. Am J Hypertens 13 (2000) 1139-1148
14. Kokotailo R.A., and Hill M.D. Coding of stroke and stroke risk factors using international classification of diseases, revisions 9 and 10. Stroke 36 (2005) 1776-1781
15. Spiering W., Kroon A.A., Fuss-Lejeune M.M., Daemen M.J., and de Leeuw P.W. Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet. Hypertension 36 (2000) 411-416
16. Szolnoki Z., Havasi V., Talian G., Bene J., Komlosi K., Somogyvari F., Kondacs A., Szabo M., Fodor L., Bodor A., and Melegh B. Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers. J Mol Neurosci 28 (2006) 285-290
17. Schaid D.J., and Jacobsen S.J. Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions. Am J Epidemiol 149 (1999) 706-711
18. Hassan A., Gormley K., O'Sullivan M., Knight J., Sham P., Vallance P., Bamford J., and Markus H. Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease. Stroke 35 (2004) 654-659
19. Markus H.S., Ruigrok Y., Ali N., and Powell J.F. Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma. Stroke 29 (1998) 1908-1911
20. MacLeod M.J., Dahiyat M.T., Cumming A., Meiklejohn D., Shaw D., and St Clair D. No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke. Neurology 53 (1999) 418-420
21. Shoemaker J., Painter I., and Weir B.S. A Bayesian characterization of Hardy-Weinberg disequilibrium. Genetics 149 (1998) 2079-2088
22. Zou G.Y., and Donner A. The merits of testing Hardy-Weinberg equilibrium in the analysis of unmatched case-control data: a cautionary note. Ann Hum Genet 70 (2006) 923-933
23. Henskens L.H., Kroon A.A., van Boxtel M.P., Hofman P.A., and de Leeuw P.W. Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension. Stroke 36 (2005) 1869-1873
24. Vermeer S.E., Hollander M., van Dijk E.J., Hofman A., Koudstaal P.J., and Breteler M.M. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke 34 (2003) 1126-1129