High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis

Arthritis Research and Therapy

Volumn 9, Issue , 2007, Pages

  Magnusson, Sofia E ^a   Engström, Marianne ^b   Jacob, Uwe ^c   Ulfgren, Ann Kristin ^b   Kleinau, Sandra ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SuppreMol   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; ETANERCEPT; FC RECEPTOR; FC RECEPTOR 1; FC RECEPTOR 2; FC RECEPTOR 2B; FC RECEPTOR 3; GLUCOCORTICOID; GLUCOSAMINE; IMMUNOGLOBULIN RECEPTOR; INFLIXIMAB; METHOTREXATE; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PREDNISONE; SALAZOSULFAPYRIDINE; TRIAMCINOLONE HEXACETONIDE; UNCLASSIFIED DRUG; FCGR1A PROTEIN, HUMAN; FCGR2B PROTEIN, HUMAN; FCGR3A PROTEIN, HUMAN;

ARTICLE; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE DURATION; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; JOINT BIOPSY; MACROPHAGE; MALE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; STAINING; SYNOVIUM; UPREGULATION; VOLUNTEER; ADULT; AGED; ANTIBODY SPECIFICITY; BIOSYNTHESIS; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; METABOLISM; MIDDLE AGED;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ARTHRITIS, RHEUMATOID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOCORTICOIDS; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MIDDLE AGED; RECEPTORS, IGG; SYNOVIAL MEMBRANE;

EID: 34250769953     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2206     Document Type: Article

References (46)

1. Schellekens GA de Jong BA van den Hoogen FH van de Putte LB van Venrooij WJ Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies J Clin Invest 1998 101 273-281 508564 9421490
2. Rantapaa-Dahlqvist S de Jong BA Berglin E Hallmans G Wadell G Stenlund H Sundin U van Venrooij WJ Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis Arthritis Rheum 2003 48 2741-2749 10.1002/art.11223 14558078
3. Takai T Ono M Hikida M Ohmori H Ravetch JV Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice Nature 1996 379 346-349 10.1038/379346a0 8552190
4. Diaz de Stahl T Andren M Martinsson P Verbeek JS Kleinau S Expression of FcgammaRIII is required for development of collagen-induced arthritis Eur J Immunol 2002 32 2915-2922 10.1002/ 1521-4141(2002010)32:10<2915::AID-IMMU2915>3.0.CO;2-4 12355445
5. Ji H Ohmura K Mahmood U Lee DM Hofhuis FM Boackle SA Takahashi K Holers VM Walport M Gerard C Arthritis critically dependent on innate immune system players Immunity 2002 16 157-168 10.1016/S1074-7613(02)00275-3 11869678
6. Kaplan CD O'Neill SK Koreny T Czipri M Finnegan A Development of inflammation in proteoglycan-induced arthritis is dependent on Fc gamma R regulation of the cytokine/chemokine environment J Immunol 2002 169 5851-5859 12421967
7. Kagari T Tanaka D Doi H Shimozato T Essential role of Fc gamma receptors in anti-type II collagen antibody-induced arthritis J Immunol 2003 170 4318-4324 12682268
8. van Lent PL van Vuuren AJ Blom AB Holthuysen AE van de Putte LB van de Winkel JG van den Berg WB Role of Fc receptor gamma chain in inflammation and cartilage damage during experimental antigen-induced arthritis Arthritis Rheum 2000 43 740-752 10.1002/ 1529-0131(200004)43:4<740::AID-ANR4>3.0.CO;2-0 10765918
9. Yuasa T Kubo S Yoshino T Ujike A Matsumura K Ono M Ravetch JV Takai T Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis J Exp Med 1999 189 187-194 10.1084/ jem.189.1.187 9874575
10. Kleinau S Martinsson P Heyman B Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors J Exp Med 2000 191 1611-1616 10.1084/jem.191.9.1611 10790435
11. Ravetch JV Perussia B Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions J Exp Med 1989 170 481-497 10.1084/jem.170.2.481 2526846
12. Fossati G Bucknall RC Edwards SW Fcgamma receptors in autoimmune diseases Eur J Clin Invest 2001 31 821-831 10.1046/ j.1365-2362.2001.00881.x 11589725
13. van Sorge NM van der Pol WL van de Winkel JG FcgammaR polymorphisms: Implications for function, disease susceptibility and immunotherapy Tissue Antigens 2003 61 189-202 10.1034/j.1399-0039.2003.00037.x 12694568
14. Koene HR Kleijer M Algra J Roos D von dem Borne AE de Haas M Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype Blood 1997 90 1109-1114 9242542
15. Wu J Edberg JC Redecha PB Bansal V Guyre PM Coleman K Salmon JE Kimberly RP A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease J Clin Invest 1997 100 1059-1070 508280 9276722
16. Morgan AW Griffiths B Ponchel F Montague BM Ali M Gardner PP Gooi HC Situnayake RD Markham AF Emery P Fcgamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups Arthritis Rheum 2000 43 2328-2334 10.1002/ 1529-0131(200010)43:10<2328::AID-ANR21>3.0.CO;2-Z 11037893
17. Nieto A Caliz R Pascual M Mataran L Garcia S Martin J Involvement of Fcgamma receptor IIIA genotypes in susceptibility to rheumatoid arthritis Arthritis Rheum 2000 43 735-739 10.1002/ 1529-0131(200004)43:4<735::AID-ANR3>3.0.CO;2-Q 10765917
18. Chen JY Wang CM Wu JM Ho HH Luo SF Association of rheumatoid factor production with FcgammaRIIIa polymorphism in Taiwanese rheumatoid arthritis Clin Exp Immunol 2006 144 10-16 10.1111/ j.1365-2249.2006.03021.x 16542359
19. Radstake TR Franke B Wenink MH Nabbe KC Coenen MJ Welsing P Bonvini E Koenig S van den Berg WB Barrera P The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis Arthritis Rheum 2006 54 3828-3837 10.1002/art.22275 17133580
20. Kawanaka N Yamamura M Aita T Morita Y Okamoto A Kawashima M Iwahashi M Ueno A Ohmoto Y Makino H CD14+, CD16+ blood monocytes and joint inflammation in rheumatoid arthritis Arthritis Rheum 2002 46 2578-2586 10.1002/art.10545 12384915
21. Wijngaarden S van Roon JA Bijlsma JW van de Winkel JG Lafeber FP Fcgamma receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic drugs Rheumatology (Oxford) 2003 42 681-688 10.1093/ rheumatology/keg174 12709546
22. Torsteinsdottir I Arvidson NG Hallgren R Hakansson L Monocyte activation in rheumatoid arthritis (RA): Increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids Clin Exp Immunol 1999 115 554-560 10.1046/j.1365-2249.1999.00817.x 10193433
23. Hepburn AL Mason JC Davies KA Expression of Fc{gamma} and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis Rheumatology (Oxford) 2004 43 547-554 10.1093/ rheumatology/keh112 14747618
24. Bunescu A Seideman P Lenkei R Levin K Egberg N Enhanced Fcgamma receptor I, alphaMbeta2 integrin receptor expression by monocytes and neutrophils in rheumatoid arthritis: Interaction with platelets J Rheumatol 2004 31 2347-2355 15570633
25. Wijngaarden S van de Winkel JG Jacobs KM Bijlsma JW Lafeber FP van Roon JA A shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis Arthritis Rheum 2004 50 3878-3887 10.1002/art.20672 15593228
26. Broker BM Edwards JC Fanger MW Lydyard PM The prevalence and distribution of macrophages bearing Fc gamma R I, Fc gamma R II, and Fc gamma R III in synovium Scand J Rheumatol 1990 19 123-135 1692420
27. Blom AB Radstake TR Holthuysen AE Sloetjes AW Pesman GJ Sweep FG van de Loo FA Joosten LA Barrera P van Lent PL Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase Arthritis Rheum 2003 48 1002-1014 10.1002/art.10871 12687542
28. Edwards JC Blades S Cambridge G Restricted expression of Fc gammaRIII (CD16) in synovium and dermis: Implications for tissue targeting in rheumatoid arthritis (RA) Clin Exp Immunol 1997 108 401-406 10.1046/ j.1365-2249.1997.3941286.x 9182883
29. Ulfgren AK Grondal L Lindblad S Khademi M Johnell O Klareskog L Andersson U Interindividual and intra-articular variation of proinflammatory cytokines in patients with rheumatoid arthritis: potential implications for treatment Ann Rheum Dis 2000 59 439-447 1753152 10834861 10.1136/ard.59.6.439
30. Pulford KA Sipos A Cordell JL Stross WP Mason DY Distribution of the CD68 macrophage/myeloid associated antigen Int Immunol 1990 2 973-980 10.1093/intimm/2.10.973 2078523
31. Kunisch E Fuhrmann R Roth A Winter R Lungershausen W Kinne RW Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1, EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry Ann Rheum Dis 2004 63 774-784 10.1136/ard.2003.013029 15194571
32. Sulahian TH Hogger P Wahner AE Wardwell K Goulding NJ Sorg C Droste A Stehling M Wallace PK Morganelli PM Human monocytes express CD163, which is upregulated by IL-10 and identical to p155 Cytokine 2000 12 1312-1321 10.1006/cyto.2000.0720 10975989
33. Moestrup SK Moller HJ CD163: A regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response Ann Med 2004 36 347-354 10.1080/07853890410033171 15478309
34. Looney RJ Abraham GN Anderson CL Human monocytes and U937 cells bear two distinct Fc receptors for IgG J Immunol 1986 136 1641-1647 2936805
35. Mackay M Stanevsky A Wang T Aranow C Li M Koenig S Ravetch JV Diamond B Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE J Exp Med 2006 203 2157-2164 10.1084/jem.20051503 16923849
36. Barnes N Gavin AL Tan PS Mottram P Koentgen F Hogarth PM FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses Immunity 2002 16 379-389 10.1016/S1074-7613(02)00287-X 11911823
37. Nabbe KC van Lent PL Holthuysen AE Kolls JK Verbeek S van den Berg WB FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis Am J Pathol 2003 163 743-752 12875993
38. McKenzie SE Taylor SM Malladi P Yuhan H Cassel DL Chien P Schwartz E Schreiber AD Surrey S Reilly MP The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: A transgenic mouse model J Immunol 1999 162 4311-4318 10201963
39. Tan Sardjono C Mottram PL van de Velde NC Powell MS Power D Slocombe RF Wicks IP Campbell IK McKenzie SE Brooks M Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice Arthritis Rheum 2005 52 3220-3229 10.1002/art.21344 16200626
40. Andren M Xiang Z Nilsson G Kleinau S FcgammaRIII-expressing macrophages are essential for development of collagen-induced arthritis Scand J Immunol 2006 63 282-289 10.1111/j.1365-3083.2006.01743.x 16623928
41. af Klint E Grundtman C Engstrom M Catrina AI Makrygiannakis D Klareskog L Andersson U Ulfgren AK Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels Arthritis Rheum 2005 52 3880-3889 10.1002/ art.21488 16320336
42. Fries LF Brickman CM Frank MM Monocyte receptors for the Fc portion of IgG increase in number in autoimmune hemolytic anemia and other hemolytic states and are decreased by glucocorticoid therapy J Immunol 1983 131 1240-1245 6224854
43. Wijngaarden S van Roon JA van de Winkel JG Bijlsma JW Lafeber FP Down-regulation of activating Fcgamma receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment Rheumatology (Oxford) 2005 44 729-734 10.1093/rheumatology/keh583 15757966
44. Lindblad S Hedfors E The synovial membrane of healthy individuals - immunohistochemical overlap with synovitis Clin Exp Immunol 1987 69 41-47 3308223
45. Singh JA Arayssi T Duray P Schumacher HR Immunohistochemistry of normal human knee synovium: A quantitative study Ann Rheum Dis 2004 63 785-790 10.1136/ard.2003.013383 15194572
46. Tak PP Smeets TJ Daha MR Kluin PM Meijers KA Brand R Meinders AE Breedveld FC Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity Arthritis Rheum 1997 40 217-225 10.1002/art.1780400206 9041933