메뉴 건너뛰기




Volumn 176, Issue 2, 2007, Pages 105-109

Incidence and significance of the JAK2 V617F mutation in patients with chronic myeloproliferative disorders

Author keywords

Essential thrombocythaemia; Idiopathic myelofibrosis; JAK2 V617F; Myeloproliferative disorders; Polycythaemia vera; Tyrosine kinase

Indexed keywords

DNA; JANUS KINASE 2; PHENYLALANINE; VALINE;

EID: 34250763759     PISSN: 00211265     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11845-007-0026-x     Document Type: Article
Times cited : (7)

References (35)
  • 2
    • 30844433972 scopus 로고    scopus 로고
    • Molecular monitoring of BCR-ABL as a guide to clinical management in chronic myeloid leukaemia
    • Hughes T, Branford S (2006) Molecular monitoring of BCR-ABL as a guide to clinical management in chronic myeloid leukaemia. Blood Rev 20:29-41
    • (2006) Blood Rev , vol.20 , pp. 29-41
    • Hughes, T.1    Branford, S.2
  • 3
    • 15944404601 scopus 로고    scopus 로고
    • The development of Imatinib as a therapeutic agent for chronic myeloid leukaemia
    • Deininger M, Buchdunger E, Druker BJ (2005) The development of Imatinib as a therapeutic agent for chronic myeloid leukaemia. Blood 105:2640-2653
    • (2005) Blood , vol.105 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 4
    • 27244452986 scopus 로고    scopus 로고
    • Genetics of myeloid malignancies: Pathogenetic and clinical implications
    • Frohling S, Scholl C, Gilliland DG, Levine RL (2005) Genetics of myeloid malignancies: Pathogenetic and clinical implications. J Clin Oncol 23:6285-6295
    • (2005) J Clin Oncol , vol.23 , pp. 6285-6295
    • Frohling, S.1    Scholl, C.2    Gilliland, D.G.3    Levine, R.L.4
  • 5
    • 9644275709 scopus 로고    scopus 로고
    • Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders
    • Kralovics R, Skoda RC (2005) Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders. Blood Rev 19:1-13
    • (2005) Blood Rev , vol.19 , pp. 1-13
    • Kralovics, R.1    Skoda, R.C.2
  • 6
    • 20144363192 scopus 로고    scopus 로고
    • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    • Baxter EJ, Scott LM, Campbell PJ et al (2005) Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365:1054-1061
    • (2005) Lancet , vol.365 , pp. 1054-1061
    • Baxter, E.J.1    Scott, L.M.2    Campbell, P.J.3
  • 7
    • 17644424955 scopus 로고    scopus 로고
    • A gain-of-function mutation of JAK2 in myeloproliferative disorders
    • Kralovics R, Passamonti F, Buser AS et al (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Eng J Med 352:1779-1790
    • (2005) N Eng J Med , vol.352 , pp. 1779-1790
    • Kralovics, R.1    Passamonti, F.2    Buser, A.S.3
  • 8
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • Levine RL, Wadleigh M, Cools J et al (2005) Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7:387-397
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3
  • 9
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • James C, Ugo V, Le Couedic JP, et al (2005) A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434:1144-1148
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3
  • 10
    • 21344467318 scopus 로고    scopus 로고
    • Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
    • Jones AV, Kreil S, Zoi K et al (2005) Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 106:2162-2168
    • (2005) Blood , vol.106 , pp. 2162-2168
    • Jones, A.V.1    Kreil, S.2    Zoi, K.3
  • 11
    • 20744460045 scopus 로고    scopus 로고
    • Identification of an acquired JAK2 mutation in polycythemia vera
    • Zhao R, Xing S, Li Z, Li Q, Krantz SB, Zhao ZJ (2005) Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem 280:22788-22792
    • (2005) J Biol Chem , vol.280 , pp. 22788-22792
    • Zhao, R.1    Xing, S.2    Li, Z.3    Li, Q.4    Krantz, S.B.5    Zhao, Z.J.6
  • 13
    • 19344362958 scopus 로고    scopus 로고
    • On the molecular origins of the chronic myeloproliferative disorders: It all makes sense
    • Kaushansky K (2005) On the molecular origins of the chronic myeloproliferative disorders: It all makes sense. Blood 105:4187-4190
    • (2005) Blood , vol.105 , pp. 4187-4190
    • Kaushansky, K.1
  • 14
    • 25844447519 scopus 로고    scopus 로고
    • JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML and megakaryoblastic leukaemia
    • Jelinek J, Oki Y, Gharibyan V et al (2005) JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML and megakaryoblastic leukaemia. Blood 106:3370-3373
    • (2005) Blood , vol.106 , pp. 3370-3373
    • Jelinek, J.1    Oki, Y.2    Gharibyan, V.3
  • 15
    • 25844518265 scopus 로고    scopus 로고
    • The JAK2 V617F activating mutation occurs in chronic myelomonocytic leukaemia and acute myeloid leukaemia, but not in acute lymphoblastic leukaemia or chronic lymphocytic leukaemia
    • Levine RL, Loriaux M, Huntly BJ et al (2005) The JAK2 V617F activating mutation occurs in chronic myelomonocytic leukaemia and acute myeloid leukaemia, but not in acute lymphoblastic leukaemia or chronic lymphocytic leukaemia. Blood 106:3377-3379
    • (2005) Blood , vol.106 , pp. 3377-3379
    • Levine, R.L.1    Loriaux, M.2    Huntly, B.J.3
  • 16
    • 33644752653 scopus 로고    scopus 로고
    • The JAK2 V617F mutation in de novo acute myelogenous leukemias
    • Lee JW, Kim YG, Soung YH et al (2006) The JAK2 V617F mutation in de novo acute myelogenous leukemias. Oncogene 25:1434-1436
    • (2006) Oncogene , vol.25 , pp. 1434-1436
    • Lee, J.W.1    Kim, Y.G.2    Soung, Y.H.3
  • 17
    • 28544431813 scopus 로고    scopus 로고
    • The JAK2 V617F tyrosine kinase mutation in myelodysplastic syndromes (MDS) developing myelofibrosis indicates the myeloproliferative nature in a subset of MDS patients
    • Ohyashiki K, Aota Y, Akahane D et al (2005) The JAK2 V617F tyrosine kinase mutation in myelodysplastic syndromes (MDS) developing myelofibrosis indicates the myeloproliferative nature in a subset of MDS patients. Leukemia 19:2359-2360
    • (2005) Leukemia , vol.19 , pp. 2359-2360
    • Ohyashiki, K.1    Aota, Y.2    Akahane, D.3
  • 18
    • 27144432878 scopus 로고    scopus 로고
    • JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukaemia
    • Tono C, Xu G, Toki T et al (2005) JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukaemia. Leukemia 19:1843-1844
    • (2005) Leukemia , vol.19 , pp. 1843-1844
    • Tono, C.1    Xu, G.2    Toki, T.3
  • 19
    • 29144437081 scopus 로고    scopus 로고
    • Chronic neutrophilic leukaemia with an associated V617F JAK2 tyrosine kinase mutation
    • McLornan DP, Percy MJ, Jones AV, Cross NC, McMullin MF (2005) Chronic neutrophilic leukaemia with an associated V617F JAK2 tyrosine kinase mutation. Haematologica 90:1696-1697
    • (2005) Haematologica , vol.90 , pp. 1696-1697
    • McLornan, D.P.1    Percy, M.J.2    Jones, A.V.3    Cross, N.C.4    McMullin, M.F.5
  • 20
    • 33644987681 scopus 로고    scopus 로고
    • Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma
    • Melzner I, Weniger MA, Menz CK, Moller P (2006) Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma. Leukemia 20:157-158
    • (2006) Leukemia , vol.20 , pp. 157-158
    • Melzner, I.1    Weniger, M.A.2    Menz, C.K.3    Moller, P.4
  • 21
    • 30644470844 scopus 로고    scopus 로고
    • JAK2 V617F mutation is uncommon in non-Hodgkin lymphomas
    • Lee JW, Soung YH, Kim SY et al (2006) JAK2 V617F mutation is uncommon in non-Hodgkin lymphomas. Leuk Lymphoma 47:313-314
    • (2006) Leuk Lymphoma , vol.47 , pp. 313-314
    • Lee, J.W.1    Soung, Y.H.2    Kim, S.Y.3
  • 22
    • 27244450310 scopus 로고    scopus 로고
    • The V617F mutation in JAK2 is not found in childhood acute lymphoblastic leukaemia
    • Sulong S, Case M, Minto L, Wilkins B, Hall A, Irving J (2005) The V617F mutation in JAK2 is not found in childhood acute lymphoblastic leukaemia. Brit J Haematol 130:964-965
    • (2005) Brit J Haematol , vol.130 , pp. 964-965
    • Sulong, S.1    Case, M.2    Minto, L.3    Wilkins, B.4    Hall, A.5    Irving, J.6
  • 23
    • 0032757710 scopus 로고    scopus 로고
    • Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukaemia for detection of minimal residual disease Report of the BIOMED-1 concerted action: Investigation of minimal residual disease in acute leukaemia
    • van Dongen JJ, Macintyre EA, Gabert JA et al (1999) Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukaemia for detection of minimal residual disease. Report of the BIOMED-1 concerted action: Investigation of minimal residual disease in acute leukaemia. Leukemia 13:1901-1928
    • (1999) Leukemia , vol.13 , pp. 1901-1928
    • van Dongen, J.J.1    Macintyre, E.A.2    Gabert, J.A.3
  • 26
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both atypical myeloproliferative disorders and myelodysplastic syndromes
    • Steensma DP, Dewald GW, Lasho TL et al (2005) The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both atypical myeloproliferative disorders and myelodysplastic syndromes. Blood 106:1207-1209
    • (2005) Blood , vol.106 , pp. 1207-1209
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3
  • 27
    • 27144466017 scopus 로고    scopus 로고
    • The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders
    • Scott LM, Campbell PJ, Baxter EJ et al (2005) The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders. Blood 106:2920-2921
    • (2005) Blood , vol.106 , pp. 2920-2921
    • Scott, L.M.1    Campbell, P.J.2    Baxter, E.J.3
  • 28
    • 31544477194 scopus 로고    scopus 로고
    • The clinical phenotype of wild-type, heterozygous and homozygous JAK2 (V617F) in polycythemia vera
    • Tefferi A, Lasho TL, Schwager SM et al (2006) The clinical phenotype of wild-type, heterozygous and homozygous JAK2 (V617F) in polycythemia vera. Cancer 106:631-635
    • (2006) Cancer , vol.106 , pp. 631-635
    • Tefferi, A.1    Lasho, T.L.2    Schwager, S.M.3
  • 29
    • 27744606173 scopus 로고    scopus 로고
    • JAK2 mutation in essential thrombocythaemia: Clinical associations and long-term prognostic relevance
    • Wolanskyj AP, Lasho TL, Schwager SM et al (2005) JAK2 mutation in essential thrombocythaemia: Clinical associations and long-term prognostic relevance. Brit J Haematol 131:208-213
    • (2005) Brit J Haematol , vol.131 , pp. 208-213
    • Wolanskyj, A.P.1    Lasho, T.L.2    Schwager, S.M.3
  • 30
    • 33644826144 scopus 로고    scopus 로고
    • The presence of the JAK2 V617F mutation is associated with a higher haemoglobin and increased risk of thrombosis in essential thrombocythaemia
    • Cheung B, Radia D, Pantelidis P, Yadegarfar G, Harrison C (2006) The presence of the JAK2 V617F mutation is associated with a higher haemoglobin and increased risk of thrombosis in essential thrombocythaemia. Brit J Haematol 132:244-245
    • (2006) Brit J Haematol , vol.132 , pp. 244-245
    • Cheung, B.1    Radia, D.2    Pantelidis, P.3    Yadegarfar, G.4    Harrison, C.5
  • 31
    • 30844444135 scopus 로고    scopus 로고
    • The JAK2 (V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: Lineage specificity and clinical correlates
    • Tefferi A, Lasho TL, Schwager SM et al (2005) The JAK2 (V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: Lineage specificity and clinical correlates. Brit J Haematol 131:320-328
    • (2005) Brit J Haematol , vol.131 , pp. 320-328
    • Tefferi, A.1    Lasho, T.L.2    Schwager, S.M.3
  • 32
    • 33344471678 scopus 로고    scopus 로고
    • The V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis
    • Campbell PJ, Griesshammer M, Dohner K et al (2006) The V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis. Blood 107:2098-2100
    • (2006) Blood , vol.107 , pp. 2098-2100
    • Campbell, P.J.1    Griesshammer, M.2    Dohner, K.3
  • 33
    • 10344262019 scopus 로고    scopus 로고
    • Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies
    • Bench A, Li J, Huntly BJ et al (2004) Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies. Brit J Haematol 127:509-518
    • (2004) Brit J Haematol , vol.127 , pp. 509-518
    • Bench, A.1    Li, J.2    Huntly, B.J.3
  • 34
    • 24644453436 scopus 로고    scopus 로고
    • Dido gene expression alterations are implicated in the induction of haematological myeloid neoplasms
    • Futterer A, Campanero MR, Leonardo E et al (2005) Dido gene expression alterations are implicated in the induction of haematological myeloid neoplasms. J Clin Invest 115:2351-2362
    • (2005) J Clin Invest , vol.115 , pp. 2351-2362
    • Futterer, A.1    Campanero, M.R.2    Leonardo, E.3
  • 35
    • 22544482989 scopus 로고    scopus 로고
    • Targeting mutated protein tyrosine kinases and their signalling pathways in hematologic malignancies
    • Chalandon Y, Schwaller J (2005) Targeting mutated protein tyrosine kinases and their signalling pathways in hematologic malignancies. Haematologica 90:949-968
    • (2005) Haematologica , vol.90 , pp. 949-968
    • Chalandon, Y.1    Schwaller, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.