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Volumn 4, Issue 3, 2007, Pages 485-498

Time-Series Modeling of Multiple Sclerosis Disease Activity: A Promising Window on Disease Progression and Repair Potential?

Author keywords

disease modeling; lesion evolution; morphometry; Multiple sclerosis; repair; serial MRI

Indexed keywords

ANISOTROPY; ARTICLE; DEMYELINATION; DIFFUSION TENSOR IMAGING; DISEASE ACTIVITY; DISEASE COURSE; HISTOLOGY; HUMAN; IN VIVO STUDY; LEUKODYSTROPHY; MULTIPLE SCLEROSIS; MYELIN DEFICIENCY; MYELINATION; NERVE DEGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERIPHERAL NERVE; PHENYLKETONURIA; PRIORITY JOURNAL; REMYELINIZATION; SCHIZOPHRENIA;

EID: 34250761334     PISSN: 19337213     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nurt.2007.05.008     Document Type: Article
Times cited : (32)

References (51)
  • 1
    • 0024504359 scopus 로고
    • The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability
    • Weinshenker B.G., Bass B., Rice G.P., et al. The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 112 (1989) 133-146
    • (1989) Brain , vol.112 , pp. 133-146
    • Weinshenker, B.G.1    Bass, B.2    Rice, G.P.3
  • 2
    • 0027537209 scopus 로고
    • Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up
    • Runmarker B., and Andersen O. Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up. Brain 116 (1993) 117-134
    • (1993) Brain , vol.116 , pp. 117-134
    • Runmarker, B.1    Andersen, O.2
  • 3
    • 27644552194 scopus 로고    scopus 로고
    • Cortical demyelination and diffuse white matter injury in multiple sclerosis
    • Kutzelnigg A., Lucchinetti C.F., Stadelmann C., et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 128 (2005) 2705-2712
    • (2005) Brain , vol.128 , pp. 2705-2712
    • Kutzelnigg, A.1    Lucchinetti, C.F.2    Stadelmann, C.3
  • 4
    • 0034765063 scopus 로고    scopus 로고
    • Immunopathology of secondary-progressive multiple sclerosis
    • Prineas J.W., Kwon E.E., Cho E.S., et al. Immunopathology of secondary-progressive multiple sclerosis. Ann Neurol 50 (2001) 646-657
    • (2001) Ann Neurol , vol.50 , pp. 646-657
    • Prineas, J.W.1    Kwon, E.E.2    Cho, E.S.3
  • 5
    • 0034642247 scopus 로고    scopus 로고
    • Whole brain volume changes in patients with progressive MS treated with cladribine
    • Filippi M., Rovaris M., Iannucci G., et al. Whole brain volume changes in patients with progressive MS treated with cladribine. Neurology 55 (2000) 1714-1718
    • (2000) Neurology , vol.55 , pp. 1714-1718
    • Filippi, M.1    Rovaris, M.2    Iannucci, G.3
  • 6
    • 0033759398 scopus 로고    scopus 로고
    • European Study Group on Interferon β-1b in Secondary Progressive Multiple Sclerosis. The effect of interferon β-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis
    • Molyneux P.D., Kappos L., Polman C., et al. European Study Group on Interferon β-1b in Secondary Progressive Multiple Sclerosis. The effect of interferon β-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis. Brain 123 (2000) 2256-2263
    • (2000) Brain , vol.123 , pp. 2256-2263
    • Molyneux, P.D.1    Kappos, L.2    Polman, C.3
  • 7
    • 0033546980 scopus 로고    scopus 로고
    • Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H
    • Paolillo A., Coles A.J., Molyneux P.D., et al. Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H. Neurology 53 (1999) 751-757
    • (1999) Neurology , vol.53 , pp. 751-757
    • Paolillo, A.1    Coles, A.J.2    Molyneux, P.D.3
  • 8
    • 33749014399 scopus 로고    scopus 로고
    • Is late-onset multiple sclerosis associated with a worse outcome?
    • Tremlett H., and Devonshire V. Is late-onset multiple sclerosis associated with a worse outcome?. Neurology 67 (2006) 954-959
    • (2006) Neurology , vol.67 , pp. 954-959
    • Tremlett, H.1    Devonshire, V.2
  • 9
    • 33749013556 scopus 로고    scopus 로고
    • Baseline MRI predicts future attacks and disability in clinically isolated syndromes
    • Tintore M., Rovira A., Rio J., et al. Baseline MRI predicts future attacks and disability in clinically isolated syndromes. Neurology 67 (2006) 968-972
    • (2006) Neurology , vol.67 , pp. 968-972
    • Tintore, M.1    Rovira, A.2    Rio, J.3
  • 10
    • 0242609810 scopus 로고    scopus 로고
    • The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study
    • Chard D.T., Brex P.A., Ciccarelli O., et al. The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study. J Neurol Neurosurg Psychiatry 74 (2003) 1551-1554
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 1551-1554
    • Chard, D.T.1    Brex, P.A.2    Ciccarelli, O.3
  • 11
    • 0037379402 scopus 로고    scopus 로고
    • Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process
    • Confavreux C., Vukusic S., and Adeleine P. Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process. Brain 126 (2003) 770-782
    • (2003) Brain , vol.126 , pp. 770-782
    • Confavreux, C.1    Vukusic, S.2    Adeleine, P.3
  • 12
    • 0024796845 scopus 로고
    • The natural history of multiple sclerosis: a geographically based study. 2. Predictive value of the early clinical course
    • Weinshenker B.G., Bass B., Rice G.P., et al. The natural history of multiple sclerosis: a geographically based study. 2. Predictive value of the early clinical course. Brain 112 (1989) 1419-1428
    • (1989) Brain , vol.112 , pp. 1419-1428
    • Weinshenker, B.G.1    Bass, B.2    Rice, G.P.3
  • 13
    • 33749027200 scopus 로고    scopus 로고
    • Long-term subcutaneous interferon β-1a therapy in patients with relapsing-remitting MS
    • Kappos L., Traboulsee A., Constantinescu C., et al. Long-term subcutaneous interferon β-1a therapy in patients with relapsing-remitting MS. Neurology 67 (2006) 944-953
    • (2006) Neurology , vol.67 , pp. 944-953
    • Kappos, L.1    Traboulsee, A.2    Constantinescu, C.3
  • 14
    • 22044435713 scopus 로고    scopus 로고
    • Patterns of enhancing lesion evolution in multiple sclerosis are uniform within patients
    • Minneboo A., Uitdehaag B.M., Adèr H.J., et al. Patterns of enhancing lesion evolution in multiple sclerosis are uniform within patients. Neurology 65 (2005) 56-61
    • (2005) Neurology , vol.65 , pp. 56-61
    • Minneboo, A.1    Uitdehaag, B.M.2    Adèr, H.J.3
  • 15
    • 0029730733 scopus 로고    scopus 로고
    • Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis
    • Truyen L., van Waesberghe J.H., van Walderveen M.A., et al. Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology 47 (1996) 1469-1476
    • (1996) Neurology , vol.47 , pp. 1469-1476
    • Truyen, L.1    van Waesberghe, J.H.2    van Walderveen, M.A.3
  • 16
    • 0032231764 scopus 로고    scopus 로고
    • Patterns of lesion development in multiple sclerosis: longitudinal observations with T1-weighted spin-echo and magnetization transfer MR
    • van Waesberghe J.H., van Walderveen M.A., Castelijns J.A., et al. Patterns of lesion development in multiple sclerosis: longitudinal observations with T1-weighted spin-echo and magnetization transfer MR. AJNR Am J Neuroradiol 19 (1998) 675-683
    • (1998) AJNR Am J Neuroradiol , vol.19 , pp. 675-683
    • van Waesberghe, J.H.1    van Walderveen, M.A.2    Castelijns, J.A.3
  • 17
    • 33746790166 scopus 로고    scopus 로고
    • Significance of T2 lesions in multiple sclerosis: a 13-year longitudinal study
    • Rudick R.A., Lee J.C., Simon J., and Fisher E. Significance of T2 lesions in multiple sclerosis: a 13-year longitudinal study. Ann Neurol 60 (2006) 236-242
    • (2006) Ann Neurol , vol.60 , pp. 236-242
    • Rudick, R.A.1    Lee, J.C.2    Simon, J.3    Fisher, E.4
  • 18
    • 0037465364 scopus 로고    scopus 로고
    • MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals
    • Cotton F., Weiner H.L., Jolesz F.A., and Guttmann C.R. MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals. Neurology 60 (2003) 640-646
    • (2003) Neurology , vol.60 , pp. 640-646
    • Cotton, F.1    Weiner, H.L.2    Jolesz, F.A.3    Guttmann, C.R.4
  • 19
    • 0036791829 scopus 로고    scopus 로고
    • Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype
    • Kalkers N.F., Ameziane N., Bot J.C., et al. Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype. Arch Neurol 59 (2002) 1572-1576
    • (2002) Arch Neurol , vol.59 , pp. 1572-1576
    • Kalkers, N.F.1    Ameziane, N.2    Bot, J.C.3
  • 20
    • 0033586376 scopus 로고    scopus 로고
    • Gadolinium MRI Meta-analysis Group. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis
    • Kappos L., Moeri D., Radue E.W., et al. Gadolinium MRI Meta-analysis Group. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis. Lancet 353 (1999) 964-969
    • (1999) Lancet , vol.353 , pp. 964-969
    • Kappos, L.1    Moeri, D.2    Radue, E.W.3
  • 21
    • 33749488304 scopus 로고    scopus 로고
    • Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis
    • Agosta F., Rovaris M., Pagani E., et al. Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis. Brain 129 (2006) 2620-2627
    • (2006) Brain , vol.129 , pp. 2620-2627
    • Agosta, F.1    Rovaris, M.2    Pagani, E.3
  • 22
    • 4444310685 scopus 로고    scopus 로고
    • Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain
    • Schmierer K., Scaravilli F., Altmann D.R., et al. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol 56 (2004) 407-415
    • (2004) Ann Neurol , vol.56 , pp. 407-415
    • Schmierer, K.1    Scaravilli, F.2    Altmann, D.R.3
  • 23
    • 0032724612 scopus 로고    scopus 로고
    • Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability
    • van Waesberghe J.H., Kamphorst W., De Groot C.J., et al. Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability. Ann Neurol 46 (1999) 747-754
    • (1999) Ann Neurol , vol.46 , pp. 747-754
    • van Waesberghe, J.H.1    Kamphorst, W.2    De Groot, C.J.3
  • 24
    • 9044245703 scopus 로고    scopus 로고
    • US National MS Society Task Force. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis
    • Miller D.H., Albert P.S., Barkhof F., et al. US National MS Society Task Force. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis. Ann Neurol 39 (1996) 6-16
    • (1996) Ann Neurol , vol.39 , pp. 6-16
    • Miller, D.H.1    Albert, P.S.2    Barkhof, F.3
  • 25
    • 15144347576 scopus 로고    scopus 로고
    • Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis
    • Filippi M., Horsfield M.A., Adèr H.J., et al. Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis. Ann Neurol 43 (1998) 499-506
    • (1998) Ann Neurol , vol.43 , pp. 499-506
    • Filippi, M.1    Horsfield, M.A.2    Adèr, H.J.3
  • 26
    • 20544433668 scopus 로고    scopus 로고
    • Resolution-dependent estimates of multiple sclerosis lesion loads
    • Erskine M.K., Cook L.L., Riddle K.E., et al. Resolution-dependent estimates of multiple sclerosis lesion loads. Can J Neurol Sci 32 (2005) 205-212
    • (2005) Can J Neurol Sci , vol.32 , pp. 205-212
    • Erskine, M.K.1    Cook, L.L.2    Riddle, K.E.3
  • 27
    • 0031693017 scopus 로고    scopus 로고
    • A multi-centre longitudinal study comparing the sensitivity of monthly MRI after standard and triple dose gadolinium-DTPA for monitoring disease activity in multiple sclerosis: implications for phase II clinical trials
    • Filippi M., Rovaris M., Capra R., et al. A multi-centre longitudinal study comparing the sensitivity of monthly MRI after standard and triple dose gadolinium-DTPA for monitoring disease activity in multiple sclerosis: implications for phase II clinical trials. Brain 121 (1998) 2011-2020
    • (1998) Brain , vol.121 , pp. 2011-2020
    • Filippi, M.1    Rovaris, M.2    Capra, R.3
  • 29
    • 0031891592 scopus 로고    scopus 로고
    • Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis
    • Molyneux P.D., Filippi M., Barkhof F., et al. Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis. Ann Neurol 43 (1998) 332-339
    • (1998) Ann Neurol , vol.43 , pp. 332-339
    • Molyneux, P.D.1    Filippi, M.2    Barkhof, F.3
  • 30
    • 0033472729 scopus 로고    scopus 로고
    • European Study Group on Interferon-β1b in Secondary Progressive Multiple Sclerosis. Effect of interferon-β1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: results of a European multicenter, randomized, double-blind, placebo-controlled trial
    • Miller D.H., Molyneux P.D., Barker G.J., et al. European Study Group on Interferon-β1b in Secondary Progressive Multiple Sclerosis. Effect of interferon-β1b on magnetic resonance imaging outcomes in secondary progressive multiple sclerosis: results of a European multicenter, randomized, double-blind, placebo-controlled trial. Ann Neurol 46 (1999) 850-859
    • (1999) Ann Neurol , vol.46 , pp. 850-859
    • Miller, D.H.1    Molyneux, P.D.2    Barker, G.J.3
  • 31
    • 0008678962 scopus 로고    scopus 로고
    • Multiple Sclerosis Collaborative Research Group (MSCRG). Intramuscular interferon β-1a for disease progression in relapsing multiple sclerosis
    • Jacobs L.D., Cookfair D.L., Rudick R.A., et al. Multiple Sclerosis Collaborative Research Group (MSCRG). Intramuscular interferon β-1a for disease progression in relapsing multiple sclerosis. Ann Neurol 39 (1996) 285-294
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 32
    • 0029161628 scopus 로고
    • Interferon β-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial
    • IFNB Multiple Sclerosis Study Group. University of British Columbia MS/MRI Analysis Group
    • IFNB Multiple Sclerosis Study Group, and University of British Columbia MS/MRI Analysis Group. Interferon β-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 45 (1995) 1277-1285
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 33
    • 0032864616 scopus 로고    scopus 로고
    • Prevention of Relapses and Disability by Interferon-β1a Subcutaneously in Multiple Sclerosis. Magnetic resonance imaging results of the PRISMS trial: a randomized, double-blind, placebo-controlled study of interferon-β1a in relapsing-remitting multiple sclerosis
    • Li D.K., and Paty D.W. Prevention of Relapses and Disability by Interferon-β1a Subcutaneously in Multiple Sclerosis. Magnetic resonance imaging results of the PRISMS trial: a randomized, double-blind, placebo-controlled study of interferon-β1a in relapsing-remitting multiple sclerosis. Ann Neurol 46 (1999) 197-206
    • (1999) Ann Neurol , vol.46 , pp. 197-206
    • Li, D.K.1    Paty, D.W.2
  • 34
    • 0029568036 scopus 로고
    • Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis
    • Filippi M., Horsfield M.A., Tofts P.S., et al. Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis. Brain 118 (1995) 1601-1612
    • (1995) Brain , vol.118 , pp. 1601-1612
    • Filippi, M.1    Horsfield, M.A.2    Tofts, P.S.3
  • 35
    • 0023706820 scopus 로고
    • Multiple sclerosis: a serial study using MRI in relapsing patients
    • Isaac C., Li D.K., Genton M., et al. Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology 38 (1988) 1511-1515
    • (1988) Neurology , vol.38 , pp. 1511-1515
    • Isaac, C.1    Li, D.K.2    Genton, M.3
  • 36
    • 0024586487 scopus 로고
    • Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients
    • Willoughby E.W., Grochowski E., Li D.K., et al. Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients. Ann Neurol 25 (1989) 43-49
    • (1989) Ann Neurol , vol.25 , pp. 43-49
    • Willoughby, E.W.1    Grochowski, E.2    Li, D.K.3
  • 37
    • 0031793235 scopus 로고    scopus 로고
    • Defining multiple sclerosis disease activity using MRI T2-weighted difference imaging
    • Lee M.A., Smith S., Palace J., and Matthews P.M. Defining multiple sclerosis disease activity using MRI T2-weighted difference imaging. Brain 121 (1998) 2095-2102
    • (1998) Brain , vol.121 , pp. 2095-2102
    • Lee, M.A.1    Smith, S.2    Palace, J.3    Matthews, P.M.4
  • 38
    • 0037122957 scopus 로고    scopus 로고
    • A longitudinal study of abnormalities on MRI and disability from multiple sclerosis
    • Brex P.A., Ciccarelli O., O'Riordan J.I., et al. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl J Med 346 (2002) 158-164
    • (2002) N Engl J Med , vol.346 , pp. 158-164
    • Brex, P.A.1    Ciccarelli, O.2    O'Riordan, J.I.3
  • 39
    • 0034193963 scopus 로고    scopus 로고
    • Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage
    • Weiner H.L., Guttmann C.R., Khoury S.J., et al. Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage. J Neuroimmunol 104 (2000) 164-173
    • (2000) J Neuroimmunol , vol.104 , pp. 164-173
    • Weiner, H.L.1    Guttmann, C.R.2    Khoury, S.J.3
  • 40
    • 0033898154 scopus 로고    scopus 로고
    • Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis
    • Khoury S.J., Guttmann C.R., Orav E.J., et al. Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch Neurol 57 (2000) 1183-1189
    • (2000) Arch Neurol , vol.57 , pp. 1183-1189
    • Khoury, S.J.1    Guttmann, C.R.2    Orav, E.J.3
  • 41
    • 0034982632 scopus 로고    scopus 로고
    • A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
    • Bitsch A., Kuhlmann T., Stadelmann C., et al. A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions. Ann Neurol 49 (2001) 793-796
    • (2001) Ann Neurol , vol.49 , pp. 793-796
    • Bitsch, A.1    Kuhlmann, T.2    Stadelmann, C.3
  • 42
    • 0042285666 scopus 로고    scopus 로고
    • Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years
    • Bagnato F., Jeffries N., Richert N.D., et al. Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years. Brain 126 (2003) 1782-1789
    • (2003) Brain , vol.126 , pp. 1782-1789
    • Bagnato, F.1    Jeffries, N.2    Richert, N.D.3
  • 43
    • 0142106286 scopus 로고    scopus 로고
    • Time-series analysis of MRI intensity patterns in multiple sclerosis
    • Meier D.S., and Guttmann C.R. Time-series analysis of MRI intensity patterns in multiple sclerosis. Neuroimage 20 (2003) 1193-1209
    • (2003) Neuroimage , vol.20 , pp. 1193-1209
    • Meier, D.S.1    Guttmann, C.R.2
  • 44
    • 33746624780 scopus 로고    scopus 로고
    • Time-series modeling of MS lesion development
    • Meier D.S., and Guttmann C.R. Time-series modeling of MS lesion development. Neuroimage 32 (2006) 531-537
    • (2006) Neuroimage , vol.32 , pp. 531-537
    • Meier, D.S.1    Guttmann, C.R.2
  • 45
    • 0345633543 scopus 로고    scopus 로고
    • A quantitative analysis of oligodendrocytes in multiple sclerosis lesions: a study of 113 cases
    • Lucchinetti C., Bruck W., Parisi J., et al. A quantitative analysis of oligodendrocytes in multiple sclerosis lesions: a study of 113 cases. Brain 122 (1999) 2279-2295
    • (1999) Brain , vol.122 , pp. 2279-2295
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3
  • 46
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
    • Lucchinetti C., Bruck W., Parisi J., et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47 (2000) 707-717
    • (2000) Ann Neurol , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3
  • 47
    • 33845294412 scopus 로고    scopus 로고
    • Remyelination is extensive in a subset of multiple sclerosis patients
    • Patrikios P., Stadelmann C., Kutzelnigg A., et al. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 129 (2006) 3165-3172
    • (2006) Brain , vol.129 , pp. 3165-3172
    • Patrikios, P.1    Stadelmann, C.2    Kutzelnigg, A.3
  • 48
    • 5444240076 scopus 로고    scopus 로고
    • Recent neuropathological findings in MS-implications for diagnosis and therapy
    • Lassmann H. Recent neuropathological findings in MS-implications for diagnosis and therapy. JNeurol 251 Suppl 4 (2004) IV2-IV5
    • (2004) JNeurol , vol.251 , Issue.SUPPL. 4
    • Lassmann, H.1
  • 49
    • 20444422539 scopus 로고    scopus 로고
    • Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases
    • Schwartz M., and Kipnis J. Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases. J Neurol Sci 233 (2005) 163-166
    • (2005) J Neurol Sci , vol.233 , pp. 163-166
    • Schwartz, M.1    Kipnis, J.2
  • 50
    • 0032231764 scopus 로고    scopus 로고
    • Patterns of lesion development in multiple sclerosis: longitudinal observations with T1-weighted spin-echo and magnetization transfer MR
    • van Waesberghe J.H., van Walderveen M.A., Castelijns J.A., et al. Patterns of lesion development in multiple sclerosis: longitudinal observations with T1-weighted spin-echo and magnetization transfer MR. AJNR Am J Neuroradiol 19 (1998) 675-683
    • (1998) AJNR Am J Neuroradiol , vol.19 , pp. 675-683
    • van Waesberghe, J.H.1    van Walderveen, M.A.2    Castelijns, J.A.3
  • 51
    • 0035964157 scopus 로고    scopus 로고
    • Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes."
    • Filippi M., Rovaris M., Rocca M.A., et al. Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes.". Neurology 57 (2001) 731-733
    • (2001) Neurology , vol.57 , pp. 731-733
    • Filippi, M.1    Rovaris, M.2    Rocca, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.