Heterogeneous expression of tumor-associated genes in disseminated breast cancer cells

Anticancer Research

Volumn 27, Issue 4 A, 2007, Pages 1769-1776

  Zieglschmid, Veit ^a   Hollmann, Christiane ^a   Gutierrez, Bertha ^a   Krehan, Andreas ^a   Kaul, Sepp ^b   Böcher, Oliver ^a  

^a AdnaGen AG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Breast cancer; Disseminated tumor cells; Expression profiling; HER 2

Indexed keywords

ANTINEOPLASTIC AGENT; CLAUDIN 7; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPITHELIAL CELL ADHESION MOLECULE; MESSENGER RNA; MUCIN 1; TRASTUZUMAB;

ADULT; AGED; BLOOD SAMPLING; BREAST CANCER; BREAST METASTASIS; CANCER CELL; CANCER CHEMOTHERAPY; CELL ASSAY; CELL SELECTION; CELL VIABILITY; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; DISSEMINATED CANCER; FOLLOW UP; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMAGNETIC SEPARATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TUMOR GENE;

ANTIGENS, NEOPLASM; BREAST NEOPLASMS; CA-15-3 ANTIGEN; CELL ADHESION MOLECULES; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENES, ERBB-2; HUMANS; IMMUNOMAGNETIC SEPARATION; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM CIRCULATING CELLS; NEOPLASM METASTASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 34250753216     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (37)

1. Cunnick GH, Jiang WG, Gomez KF and Mansel RE: Lymphangiogenesis and breast cancer metastasis. Histol Histopathol 17: 863-870, 2002.
2. Pantel K and Otte M: Occult micrometastasis: enrichment, identification and characterization of single disseminated tumour cells. Semin Cancer Biol 11: 327-337, 2001.
3. Kostler WJ, Brodowicz T, Hejna M, Wiltschke C and Zielinski CC: Detection of minimal residual disease in patients with cancer: a review of techniques, clinical implications, and emerging therapeutic consequences. Cancer Detect Prev 24: 376-403, 2000.
4. Kvalheim G, Naume B and Nesland JM: Minimal residual disease in breast cancer. Cancer Metastasis Rev 18: 101-108, 1999.
5. Hampton R, Walker M, Marshall J and Juhl H: Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. Oncogene 21: 7817-7823, 2002.
6. Zippelius A and Pantel K: RT-PCR-based detection of occult disseminated tumor cells in peripheral blood and bone marrow of patients with solid tumors. An overview. Ann N Y Acad Sci 906: 110-123, 2000.
7. Vlems FA, Diepstra JH, Cornelissen IM, Ligtenberg MJ, Wobbes T, Punt CJ, van Krieken JH, Ruers TJ and van Muijen GN: Investigations for a multi-marker RT-PCR to improve sensitivity of disseminated tumor cell detection. Anticancer Res 23: 179-186, 2003.
8. Demel U, Tilz GP, Foeldes-Papp Z, Gutierrez B, Albert W and Böcher O: Detection of tumour cells in the peripheral blood of patients with breast cancer: Development of a new sensitive specific immunomolecular assay. J Exp Clin Cancer Res 23: 465-468, 2004.
9. Zieglschmid V, Hollmann C, Gutierrez B, Albert W, Strothoff D, Gross E and Böcher O: Combination of immunomagnetic enrichment with multiplex RT-PCR analysis for the detection of disseminated tumor cells. Anticancer Res 25: 1803-1810, 2005.
10. Zieglschmid V, Hollmann C and Bocher O: Detection of disseminated tumor cells in peripheral blood. Crit Rev Clin Lab Sci 42: 155-196, 2005.
11. Normanno N, De Luca A, Castaldo A, Casamassimi A, Di Popolo A, Zarrilli R, Porcellini A, Acquaviva AM, Awedimento VE and Pignata S: Apolipoprotein A-I reverse transcriptase-polymerase chain reaction analysis for detection of hematogenous colon cancer dissemination. Int J Oncol 13: 443-447, 1998.
12. Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW and Hayes DF: Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351: 781-791, 2004.
13. Taubert H, Blumke K, Bilkenroth U, Meye A, Kutz A, Bartel F, Lautenschlager C, Ulbrich EJ, Nass N, Holzhausen HJ, Koelbl H and Lebrecht A: Detection of disseminated tumor cells in peripheral blood of patients with breast cancer: correlation to nodal status and occurrence of metastases. Gynecol Oncol 92: 256-261, 2004.
14. Zach O, Kasparu H, Wagner H, Krieger O and Lutz D: Prognostic value of tumour cell detection in peripheral blood of breast cancer patients. Acta Med Austriaca 29: 32-34, 2002.
15. Bosma AJ, Weigelt B, Lambrechts AC, Verhagen OJ, Pruntel R, Hart AA, Rodenhuis S and van't Veer LJ: Detection of circulating breast tumor cells by differential expression of marker genes. Clin Cancer Res 8: 1871-1877, 2002.
16. Bertucci F, Viens P, Hingamp P, Nasser V, Houlgatte R and Birnbaum D: Breast cancer revisited using DNA array-based gene expression profiling. Int J Cancer 103: 565-571, 2003.
17. Nacht M, Ferguson AT, Zhang W, Petroziello JM, Cook BP, Gao YH, Maguire S, Riley D, Coppola G, Landes GM, Madden SL and Sukumar S: Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer. Cancer Res 59: 5464-5470, 1999.
18. Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP and Sukumar S: Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22: 2021-2033, 2003.
19. de Cremoux P, Extra JM, Denis MG, Pierga JY, Bourstyn E, Nos C, Clough KB, Boudou E, Martin EC, Muller A, Pouillart P and Magdelenat H: Detection of MUCl-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction. Clin Cancer Res 6: 3117-3122, 2000.
20. Walsh MD, Luckie SM, Cummings MC, Antalis TM and McGuckin MA: Herterogeneity of Mucl expression by human breast carcinoma cell lines in vivo and in vitro. Breast Cancer Res Treat 58: 255-266, 2000.
21. Trebak M, Begg GE, Chong JM, Kanazireva EV, Herlyn D and Speicher DW: Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion. J Biol Chem 276: 2299-2309, 2001.
22. Litvinov SV, Bakker HA, Gourevitch MM, Velders MP and Warnaar SO: Evidence for a role of the epithelial glycoprotein 40 (Ep-CAM) in epithelial cell-cell adhesion. Cell Adhes Commun 2: 417-428, 1994.
23. Schroder CP, Ruiters MH, de Jong S, Tiebosch AT, Wesseling J, Veenstra R, de Vries J, Hoekstra HJ, de Leij LF and de Vries EG: Detection of micrometastatic breast cancer by means of real-time quantitative RT-PCR and immunostaining in perioperative blood samples and sentinel nodes. Int J Cancer 106: 611-618, 2003.
24. Fonseca FL, Soares HP, Manhani AR, Bendit I, Novaes M, Zatta SM, Arias V, Pinhal MA, Weinschenker P and del Giglio A: Peripheral blood c-erbB-2 expression by reverse transcriptase-polymerase chain reaction in breast cancer patients receiving chemotherapy. Clin Breast Cancer 3: 201-205, 2002.
25. Tsongalis GJ and Ried A Jr: HER2: the neu prognostic marker for breast cancer. Crit Rev Clin Lab Sci 38: 167-182, 2001.
26. Leone F, Perissinotto E, Viale A, Cavalloni G, Taraglio S, Capaldi A, Piacibello W, Torchio B and Aglietta M: Detection of breast cancer cell contamination in leukapheresis product by real-time quantitative polymerase chain reaction. Bone Marrow Transplant 27: 517-523, 2001.
27. Smirnov DA, Zweitzig DR, Foulk BW, Miller MC, Doyle GV, Pienta KJ, Meropol NJ, Weiner LM, Cohen SJ, Moreno JG, Connelly MC, Terstappen LW and O'Hara SM: Global gene expression profiling of circulating tumor cells. Cancer Res 65: 4993-4997, 2005.
28. Klein CA, Blankenstein TJ, Schmidt-Kittler O, Petronio M, Polzer B, Stoecklein NH and Riethmuller G: Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 360: 683-689, 2002.
29. Braun S, Hepp F, Sommer HL and Pantel K: Tumor-antigen heterogeneity of disseminated breast cancer cells: implications for immunotherapy of minimal residual disease. Int J Cancer 84: 1-5, 1999.
30. Kuukasjarvi T, Karhu R, Tanner M, Kahkonen M, Schaffer A, Nupponen N, Pennanen S, Kallioniemi A, Kallioniemi OP and Isola J: Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer. Cancer Res 57: 1597-1604, 1997.
31. Taback B, Chan AD, Kuo CT, Bostick PJ, Wang HJ, Giuliano AE and Hoon DS: Detection of occult metastatic breast cancer cells in blood by a multimolecular marker assay: correlation with clinical stage of disease. Cancer Res 61: 8845-8850, 2001.
32. Ghossein RA, Bhattacharya S and Rosai J: Molecular detection of micrometastases and circulating tumor cells in solid tumors. Clin Cancer Res 5: 1950-1960, 1999.
33. Meng S, Tripathy D, Shete S, Ashfaq R, Haley B, Perkins S, Beitsch P, Khan A, Euhus D, Osborne C, Frenkel E, Hoover S, Leitch M, Clifford E, Vitetta E, Morrison L, Herlyn D, Terstappen LW, Fleming T, Fehm T, Tucker T, Lane N, Wang J and Uhr J: HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci USA 101: 9393-9398, 2004.
34. Hayes DF, Walker TM, Singh B, Vitetta ES, Uhr JW, Gross S, Rao C, Doyle GV and Terstappen LW: Monitoring expression of HER-2 on circulating epithelial cells in patients with advanced breast cancer. Int J Oncol 21: 1111-1117, 2002.
35. Ross JS and Fletcher JA: The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Stem Cells 16: 413-428, 1998.
36. Pantel K, Schlimok G, Braun S, Kutter D, Lindemann F, Schaller G, Funke I, Izbicki JR and Riethmuller G: Differential expression of proliferation- associated molecules in individual micrometastatic carcinoma cells. J Natl Cancer Inst 85: 1419-1424, 1993.
37. Cristofanilli M, Hayes DF, Budd GT, Ellis MJ, Stopeck A, Reuben JM, Doyle GV, Matera J, Allard WJ, Miller MC, Fritsche HA, Hortobagyi GN and Terstappen LW: Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 23: 1420-1430, 2005.